Background: Artificial intelligence techniques are widely used in solving medical problems. Recently, researchers have used various deep learning techniques for the severity classification of Chikungunya disease. But these techniques suffer from overfitting and hyper-parameters tuning problems. Methods: In this paper, an artificial intelligence-based cyber-physical system (CPS) is proposed for the severity classification of Chikungunya disease. In CPS system, the physical components are integrated with computational algorithms to provide better results. Random forest (RF) is used to design the severity classification model for Chikungunya disease. However, RF suffers from overfitting and poor computational speed problems due to complex architectures and large amounts of connection weights. Therefore, an evolving RF model is proposed using the adaptive crossover-based genetic algorithm (ACGA). Results: ACGA can efficiently optimize the architecture of RF to achieve better results with better computational speed. Extensive experiments are performed by utilizing the Chikungunya disease dataset. Conclusion: Performance analysis demonstrates that ACGA-RF achieves higher performance as compared to the competitive models in terms of F-measure, accuracy, sensitivity, and specificity. The proposed CPS system can prevent users from visiting hospitals and can render services to patients living far away from hospitals.