Evaluation of a new press-fit in situ setting composite porous scaffold for cancellous bone repair: Towards a “surgeon-friendly” bone filler?

Peroglio, Marianna; Grémillard, Laurent; Eglin, David; Lezuo, Patrick; Alini, Mauro; Chevalier, Jérôme

doi:10.1016/j.actbio.2010.03.018

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…Finally, the flexibility and the trabecular‐like structure of the crosslinked PTMC was conserved in all the composite scaffolds. This advantageous property could allow to dynamically load the scaffolds for in vitro cell culture in bioreactor or to use such scaffolds as press‐fit porous filler for bone defects, as alternative to CaP‐based granules.…”

Section: Resultsmentioning

confidence: 99%

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Guillaume

Geven

Grijpma

et al. 2016

Polymers for Advanced Techs

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Designing calcium phosphate‐loaded polymeric porous scaffolds with controlled architecture using stereolithography (SLA) has great potential in the field of bone tissue engineering. However, the use of poly(ester)s with suboptimal degradation property has mainly been reported. In the present work, we introduced a poly(trimethylene carbonate) (PTMC) and nano‐hydroxyapatite (HA) resin suitable for SLA manufacturing and created cytocompatible 3D porous structure. First, the resin formulation and HA content were optimized for photo‐crosslink‐based SLA fabrication process. Subsequently, we evaluated the influence of the resin composition on physico‐chemical characteristics of fabricated films and scaffolds. Then, the influence of the biomaterial composition on human bone marrow mesenchymal stem cell viability, adhesion and proliferation was assessed. Films and macroporous scaffolds were successfully produced by photo‐crosslinking with up to 40 wt% of HA (relative to PTMC). We demonstrated that addition of HA in PTMC matrices induced a direct effect on the surface properties, in terms of wettability and topography. Additionally, mechanical tests revealed a correlation between the amounts of HA loaded in PTMC and the stiffness of the SLA‐fabricated scaffolds. Importantly, the different photo‐crosslinked biomaterials exhibited in vitro cytocompatibility, similar to tissue culture polystyrene. Those data suggest the possibility to fabricate highly tunable HA‐loaded PTMC 3D porous structures for bone tissue engineering application. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Guillaume

Geven

Grijpma

et al. 2016

Polymers for Advanced Techs

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“…The combination of polyurethanes and biocompatible, biodegradable short-chain polyesters represents a promising solution to the limitations of each individual material and encouraging early results have been reported. Previous work on polyester urethanes has shown compressive moduli ranging from cements at 49 MPa [22] to pressure-molded composites at 9000 MPa [23]. Likewise, compressive strength of these materials has ranged from 13 MPa [24] to 150 MPa [23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of novel elastomeric poly(D,L-lactide urethane) maleate composites for bone tissue engineering

Mercado-Pagán

Kang

Ker

et al. 2013

European Polymer Journal

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Here, we report the synthesis and characterization of a novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its composites with nano-hydroxyapatite (nHA) as potential weight-bearing composite. The 4PLAUMA/nHA ratios of the composites were 1:3, 2:5, 1:2 and 1:1. FTIR and NMR characterization showed urethane and maleate units integrated into the PLA matrix. Energy dispersion and Auger electron spectroscopy confirmed homogeneous distribution of nHA in the polymer matrix. Maximum moduli and strength of the composites of 4PLAUMA/nHA, respectively, are 1973.31 ± 298.53 MPa and 78.10 ± 3.82 MPa for compression, 3630.46 ± 528.32 MPa and 6.23 ± 1.44 MPa for tension, 1810.42 ± 86.10 MPa and 13.00 ± 0.72 for bending, and 282.46 ± 24.91 MPa and 5.20 ± 0.85 MPa for torsion. The maximum tensile strains of the polymer and composites are in the range of 5% to 93%, and their maximum torsional strains vary from 0.26 to 0.90. The composites exhibited very slow degradation rates in aqueous solution, from approximately 50% mass remaining for the pure polymer to 75% mass remaining for composites with high nHA contents, after a period of 8 weeks. Increase in ceramic content increased mechanical properties, but decreased maximum strain, degradation rate, and swelling of the composites. Human bone marrow stem cells and human endothelial cells adhered and proliferated on 4PLAUMA films and degradation products of the composites showed little-to-no toxicity. These results demonstrate that novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its nHA composites may have potential applications in regenerative medicine.

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“…Newer fabrication techniques have been proposed which allow greater control of pore size, porosity, scaffold shape, ease of fabrication, and reliability of physicomechanical properties. Recent fabrication techniques include 3D printing [ 24 ], stereolithography [ 25 ], in situ synthesis using a reactive phase [ 26 ], and laser cladding [ 27 ]. These methods are particularly useful for creating customized scaffolds with predictable mechanical performance.…”

Section: Innovations In Materialsmentioning

confidence: 99%

Hard tissue regeneration using bone substitutes: an update on innovations in materials

Sarkar

Lee

2015

Korean J Intern Med

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Bone is a unique organ composed of mineralized hard tissue, unlike any other body part. The unique manner in which bone can constantly undergo self-remodeling has created interesting clinical approaches to the healing of damaged bone. Healing of large bone defects is achieved using implant materials that gradually integrate with the body after healing is completed. Such strategies require a multidisciplinary approach by material scientists, biological scientists, and clinicians. Development of materials for bone healing and exploration of the interactions thereof with the body are active research areas. In this review, we explore ongoing developments in the creation of materials for regenerating hard tissues.

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Evaluation of a new press-fit in situ setting composite porous scaffold for cancellous bone repair: Towards a “surgeon-friendly” bone filler?

Cited by 13 publications

References 33 publications

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Poly(trimethylene carbonate) and nano‐hydroxyapatite porous scaffolds manufactured by stereolithography

Synthesis and characterization of novel elastomeric poly(D,L-lactide urethane) maleate composites for bone tissue engineering

Hard tissue regeneration using bone substitutes: an update on innovations in materials

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