Evaluation of a New Rapid Quantitative Immunoassay for Serum Myoglobin Versus CK-MB for Ruling Out Acute Myocardial Infarction in the Emergency Department

Brogan, Gerard X.; Friedman, Solomon; McCuskey, Charles F.; Cooling, David S; Berrutti, Luis; Thode, Henry C.; Bock, Jay L.

doi:10.1016/s0196-0644(94)70276-4

Cited by 96 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Second, since the study population was relatively small, the statistical analysis has an inherent risk of β error. 27) Third, we could not collect medical history for several patients because the study included the most severe form of AMI such as CPA on arrival. Finally, in the multivariate logistic regression model, we had to exclude several variables because of missing values.…”

Section: Discussionmentioning

confidence: 99%

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

et al. 2016

View full text Add to dashboard Cite

SummaryCompared to acute myocardial infarction (AMI) with single vessel disease (SVD) or double vessel disease (DVD), AMI with triple vessel disease (TVD) is associated with higher mortality. The aim of this study was to identify the determinants of in-hospital death in AMI with TVD. We identified AMI patients with TVD in our tertiary medical center between January 2009 and December 2014. Baseline patient characteristics including laboratory data, echocardiograms, and coronary angiograms were collected from our hospital records. We divided our study population into a survivor group and non-survivor group. Multivariate stepwise logistic regression analysis was performed to identify the determinants of in-hospital death. A total of 138 AMI patients with TVD were identified and included as the final study population. Fifteen patients died during the hospitalization (mortality rate, 10.9%). Mean systolic blood pressure (134 ± 27 mmHg) was significantly greater in the survivor group compared with the non-survivor group (114 ± 31 mmHg) (P = 0.02). The prevalence of shock on admission was significantly less in the survivor group (15.4%) than in the non-survivor group (66.7%) (P < 0.001). Multivariate stepwise logistic regression analysis revealed that shock status on admission (OR 11.50, 95% CI 3.21-41.14, P < 0.001), the left anterior descending artery (LAD) as the infarct related artery (IRA) (OR 3.83, 95% CI 1.04-14.09, P = 0.04), and serum albumin on admission (OR 0.26, 95% CI 0.08-0.84, P = 0.02) were significantly associated with in-hospital death. In conclusion, shock status on admission, the LAD as the IRA, and a low serum albumin level were the determinants of in-hospital death in AMI patients with TVD. ( 1,2) The in-hospital mortality rates of AMI complicated with cardiogenic shock with SVD, DVD, and TVD were reported to be 32.8%, 45.1%, and 58.2%, respectively. 1) Furthermore, the long-term mortality of AMI with TVD is poorer than that with DVD.2) Although several groups studied the determinants of poor clinical outcomes in AMI with multivessel disease, 3,4) the determinants of in-hospital death in AMI with TVD have not been fully investigated. It is clinically important to identify such determinants in order to obtain a better understanding of AMI with TVD, because the mortality of AMI with TVD is the greatest among AMI.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…10,11 In these studies, troponin testing has been additive to ECG data and superior to CK-MB results. Myoglobin has excellent sensitivity and negative predictive value in acute chest pain evaluation, 4,5,16 but its use in risk stratification has been limited somewhat by its lack of cardiac specificity.…”

Section: Discussionmentioning

confidence: 99%

Bedside Multimarker Testing for Risk Stratification in Chest Pain Units

2001

View full text Add to dashboard Cite

Background-Earlier, rapid evaluation in chest pain units may make patient care more efficient. A multimarker strategy (MMS) testing for several markers of myocardial necrosis with different time-to-positivity profiles also may offer clinical advantages. Methods and Results-We prospectively compared bedside quantitative multimarker testing versus local laboratory results (LL) in 1005 patients in 6 chest pain units. Myoglobin, creatine kinase-MB, and troponin I were measured at 0, 3, 6, 9 to 12, and 16 to 24 hours after admission. Two MMS were defined: MMS-1 (all 3 markers) and MMS-2 (creatine kinase-MB and troponin I only).

show abstract

“…However, because of its small molecular size and consequent rapid rise in the setting of myocardial necrosis, it has retained value as a very early marker of MI. Clinical studies have shown that the combined use of myoglobin and a more specific marker of myocardial necrosis (cardiac troponin or CK-MB) may be useful for the early exclusion of MI 27,28 . Multimarker strategies that include myoglobin have been shown to identify patients with MI more rapidly than laboratory-based determination of a single marker 29,30 .…”

Section: Biochemical Markers Of Myocardial Necrosismentioning

confidence: 99%

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes

Morrow¹,

Cannon²,

Jesse³

et al. 2007

Circulation

315

102

View full text Add to dashboard Cite

Evaluation of a New Rapid Quantitative Immunoassay for Serum Myoglobin Versus CK-MB for Ruling Out Acute Myocardial Infarction in the Emergency Department

Cited by 96 publications

References 24 publications

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

Determinants of In-Hospital Death in Acute Myocardial Infarction With Triple Vessel Disease

Bedside Multimarker Testing for Risk Stratification in Chest Pain Units

National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes

Contact Info

Product

Resources

About