Evaluation of a newly developed HPMC ophthalmic insert with sustainehttp://10.10.23.106:8080/TDXPSLIVEGANG/gateway/elsevierjournal/index.jsp#d release properties as a carrier for thermolabile therapeutics

Everaert, Arnout; Broeckx, GÃ©raldine; Fransén, Erik; Ludwig, Annick; Kiekens, Filip; Weyenberg, Wim

doi:10.1016/j.ijpharm.2015.01.042

Cited by 6 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cellulose and its derivatives have been widely used in the pharmaceutical industry due to their ability to swell and their high compatibility, which makes them suitable for drug delivery in oral tablet and capsule formulations [ 342 , 343 , 344 ]. Additionally, cellulose derivatives may be able to form hydrogels that exhibit favorable biological and rheological properties for biomedical applications [ 345 , 346 ], mainly wound dressing, transdermal patches [ 326 , 347 ], ophthalmic preparations [ 348 ] and cartilage tissue engineering [ 349 , 350 ], as well as the 3D bioprinting of cellularized structures [ 21 , 43 , 49 , 63 , 64 , 65 , 66 ].…”

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

143

View full text Add to dashboard Cite

Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

show abstract

Section: Formulation and Use Of Natural Hydrogel-based Bio-inksmentioning

confidence: 99%

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

143

View full text Add to dashboard Cite

show abstract

Nanoparticle cross-linked collagen shields for sustained delivery of pilocarpine hydrochloride

Agban

Lian

Prabakar

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Optimisation of HPMC ophthalmic inserts with sustained release properties as a carrier for thermolabile therapeutics

Everaert

Wouters

Melsbach

et al. 2017

International Journal of Pharmaceutics

View full text Add to dashboard Cite

A methodology was developed and optimised for the preparation of a new drug delivery system (DDS) with sustained release properties to allow ocular protein delivery and to limit destructive production steps during manufacturing. Elevated temperatures, shear forces and an oxidative environment should be avoided in order to prevent denaturation or oxidation of proteins. An aqueous HPMC solution was prepared using heat and casted into small semi-rod-shaped PVC blisters. The polymer solution was allowed to cool down and was partially dehydrated at room temperature. A drug solution containing glycerol, drug and water was subsequently added to rehydrate the partially dehydrated polymer matrix at a temperature of 2°C. Several parameters of the production process were varied to determine their influence on the release kinetics from HPMC inserts from three different molecules of different molecular weight. This production method was further optimised in order to shorten the rehydration time from weeks to days, while eliminating heat and shear forces on the selected drug molecules sodium fluorescein, lysozyme and albumin. Slow release kinetics were achieved for sodium fluorescein and lysozyme as model drug molecules. The higher molecular weight of albumin prevented a good penetration into the insert during the rehydration process resulting in predominantly burst release. The biocompatibility of a viscous HPMC solution was evaluated on SV40-human corneal epithelial cells with PrestoBlue and no cytotoxic effects were observed.

show abstract

Evaluation of a newly developed HPMC ophthalmic insert with sustainehttp://10.10.23.106:8080/TDXPSLIVEGANG/gateway/elsevierjournal/index.jsp#d release properties as a carrier for thermolabile therapeutics

Cited by 6 publications

References 26 publications

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Nanoparticle cross-linked collagen shields for sustained delivery of pilocarpine hydrochloride

Optimisation of HPMC ophthalmic inserts with sustained release properties as a carrier for thermolabile therapeutics

Contact Info

Product

Resources

About