Evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae

Guertler, Anne; Reinholz, Markus; Steckmeier, Stephanie; Gauglitz, Gerd G.

doi:10.1111/jdv.15228

Cited by 11 publications

(14 citation statements)

References 32 publications

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“…In our present study series, we found an apparent reduction in the striae depth and width in rendered 3D images after three treatment sessions on both sides. Very similar results were observed by Guertler et al . in their previous study using a PRIMOS clinical image system and by Harmelin et al .…”

Section: Discussionsupporting

confidence: 90%

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae

Al-Muriesh

Huang

et al. 2020

Acad Dermatol Venereol

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Backgrounds Striae distensae (SD) has a known psychological impact due to the resulting cosmetic disfigurement. Many treatment modalities have been used over the years, but no standard interventions or evaluation methods have been proposed to date. Objective We compared the efficacy and safety of non-insulated microneedle radiofrequency (NIMRF) and fractional CO 2 laser treatments of SD by objective measurements with dermoscopy and VISIA. Methods Fourteen females with severe SD were enrolled. These subjects had been treated three sessions of NIMRF and fractional CO 2 laser for the right and left abdomen, respectively. Dermoscopy and VISIA imaging data, and photographs were collected at baseline and 2 months after the last treatment session. The global aesthetic improvement scale (GIAS) was scored by patients, and blinded investigators, pain score and satisfaction score were also documented. Any side effects were recorded. Results Ten patients completed the study. The GIAS from investigators and patients showed an overall improvement but without a significant difference (P = 0.18, P = 0.17, respectively). The decreased width measured by dermoscopy was between 5% and 32% (right side) and 6-31% (left side). There was no significant difference between both sides in either the per-protocol or intention to treat analyses (P = 0.149, P = 0.161, respectively). The mean pain score was 5.35 and 2.35 on the right side and left side, respectively, which was significant (P = 0.0016). Post-inflammatory hyperpigmentation (PIH) manifested in six patients on their left sides and four patients on their right sides. In most cases, this had resolved by the 3-month follow-up. Conclusion Non-insulated microneedle radiofrequency and fractional CO 2 laser are both effective and safe treatment options for SD. PIH is a possible side effect but is more likely with fractional CO 2 laser treatment. However, it clears up in most cases. Dermoscopy and VISIA are both convenient, digitalized methods of tracking subtle changes and monitoring the efficacy of SD treatments.

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Section: Discussionsupporting

confidence: 90%

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae

Al-Muriesh

Huang

et al. 2020

Acad Dermatol Venereol

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“…A total of 50 keloids were objectively measured using PRIMOS ®pico , a three‐dimensional, high‐resolution, non‐invasive clinical imaging device (Lite Device, GF Messtechnik GmbH, Teltow, Germany). PRIMOS ®pico has been successfully used to analyse different kinds of pathologic scarring, such as hypertrophic burn scars, 12 self‐harm scars 13 and striae distensae albae, 14 and has become a standard for scar imaging.…”

Section: Methodsmentioning

confidence: 99%

Treatment of keloids using 5‐fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non‐invasive objective measures

Reinholz

Guertler

Schwaiger

et al. 2020

Acad Dermatol Venereol

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Background Intralesional 5-fluorouracil (5-FU) in combination with triamcinolone acetonide (TAC) has been recommended as a promising alternative for keloids not responding to silicone-based products, cryotherapy or intralesional corticosteroids alone. Although numerous studies support the efficacy of this regime, there is a lack of objective data. Objectives In this study, we evaluate the therapeutic effect of four courses of intralesional 5-FU in combination with TAC (3 : 1) utilizing 3D analysis (PRIMOS âpico), ultrasound and scar scales such as the Patient and Observer Scar Assessment Scales (POSAS) and the Dermatology Life Quality Index (DLQI). Methods Twenty-five patients with keloids were treated using 5-FU and TAC every 4 weeks. Objective assessments were performed and the scar scales administered at baseline, as well as during consecutive visits at 1-and 12-month follow-up (FU). Routine laboratory tests were performed at baseline and at 1-month FU. Results 3D PRIMOS and ultrasound measurements revealed highly significant and stable reductions in height (baseline mean score: 4.0

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“…Scores ranged from 0 (no impact) to 30 (maximum impact). Validated bands gave meaning to the scores as follows: 0‐1 = no effect on patients’ life; 2‐5 = small effect; 6‐10 = moderate effect; 11‐20 = very large effect; 21‐30 = extremely large effect 20 …”

Section: Methodsmentioning

confidence: 99%

“…Validated bands gave meaning to the scores as follows: 0-1 = no effect on patients' life; 2-5 = small effect; 6-10 = moderate effect; 11-20 = very large effect; 21-30 = extremely large effect. 20 Forty-four out of 60 patients (73%) of the cohort completed the study. 34 of 50 patients within the intervention group and all patients (10/10) within the control group were followed up until V2.…”

Section: Questionnairesmentioning

confidence: 99%

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group

Guertler

Jøntvedt

Clanner‐Engelshofen

et al. 2020

J of Cosmetic Dermatology

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Background Rosacea is a common inflammatory skin disorder with centrofacial erythema, flushing, telangiectasia, papules/pustules, and possible ocular or phymatous manifestation. Patients’ skin is particularly sensitive to chemical and physical stimuli leading to burning, stinging, dryness, and skin tightness. Objective Dermatological evaluation of the efficacy and safety of skin care products designed for centrofacial erythema in rosacea patients, in comparison with a control group using objective measurements. Rosacea symptoms (itching, tension, warmth, burning, dryness) and quality of life were examined. Methods Sixty Caucasians with centrofacial erythema were enrolled in an 8‐week prospective study, fifty of them exclusively using the study products (micellar water, cream, and serum) with ten participants randomly assigned to a control group. Patients were evaluated at baseline (V0), at 4 weeks (V1), and at 8 weeks (V2). Three‐dimensional objective measurements (VECTRA®) as well as standardized questionnaires were used. Results Results were compared with the control group. A significant reduction of 16% in skin redness as indicated by VECTRA® analysis was seen in the intervention group comparing V0‐V2. Furthermore, rosacea‐associated symptoms diminished by 57.1%, while life quality of affected patients within the intervention group improved by 54.5% comparing V0‐V2, respectively. Conclusions A skin care regime suitable for sensitive and redness‐prone skin led to an enhanced clinical appearance, to a decrease of associated symptoms in rosacea patients, and to an improved life quality.

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Evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae

Cited by 11 publications

References 32 publications

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae

Treatment of keloids using 5‐fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non‐invasive objective measures

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group

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Evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae

Cited by 11 publications

References 32 publications

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO2 laser treatments of striae distensae

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO2 laser treatments of striae distensae

Treatment of keloids using 5‐fluorouracil in combination with crystalline triamcinolone acetonide suspension: evaluating therapeutic effects by using non‐invasive objective measures

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group

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Product

Resources

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Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae

Dermoscopy and VISIA imager evaluations of non‐insulated microneedle radiofrequency versus fractional CO₂ laser treatments of striae distensae