Evaluation of a novel caries detecting oral rinse

Phillips, Thais Santiago; Perozo, Betty Isabel; Kataoka, Yuko; Pour, Fatemeh Movaghari; Farah, Rayane; Obiefuna, Amos Chinedu; Farokhi, Moshtagh R.

doi:10.1038/s41405-023-00134-y

Cited by 8 publications

(3 citation statements)

References 39 publications

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“…Quantitative laser fluorescence relies on the projection of visible light (ʎ = 600-700 nm, typically from a laser diode) onto suspected caries lesions which is then absorbed by endogenous fluorophores [107,108]. More recently, a caries detecting oral rinse (LumiCare TM ) has been developed which contain proprietary fluorescent starch nanoparticles that allow active initial caries lesions to be detected using a dental curing lamp [109]. Similar to dental photoinitiators, absorption by the endogenous fluorophores or the fluorescent starch nanoparticles leads to excitation of electrons, thermalisation of energy and eventually a return to ground state with the emission of longer wavelength (typically NIR), lower energy radiation.…”

Section: Transillumination and Fluorescencementioning

confidence: 99%

The power of light – From dental materials processing to diagnostics and therapeutics

A. Hadis,

Shortall,

M. Palin

2024

BIiD

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Harnessing the power of light and its photonic energy is a powerful tool in biomedical applications. Its use ranges from biomaterials processing and fabrication of polymers to diagnostics and therapeutics. Dental light curable materials have evolved over several decades and now offer very fast (≤ 10 s) and reliable polymerization through depth (4–6 mm thick). This has been achieved by developments on two fronts: (1) chemistries with more efficient light absorption characteristics (camphorquinone [CQ], ~30 L mol-1 cm1 [ʎmax 470 nm]; monoacylphosphine oxides [MAPO], ~800 L mol-1 cm-1 [ʎmax 385 nm]; bisacylphosphine oxide [BAPO], ~1,000 L mol-1 cm-1 [ʎmax 385 nm]) as well mechanistically efficient and prolonged radical generation processes during and after light irradiation, and; (2) introducing light curing technologies (light emitting diodes [LEDs] and less common lasers) with higher powers (≤ 2 W), better spectral range using multiple diodes (short: 390–405 nm; intermediate: 410–450 nm; and long: 450–480 nm), and better spatial power distribution (i.e. homogenous irradiance). However, adequate cure of materials falls short for several reasons, including improper selection of materials and lights, limitations in the chemistry of the materials, and limitations in delivering light through depth. Photonic energy has further applications in dentistry which include transillumination for diagnostics, and therapeutic applications that include photodynamic therapy, photobiomodulation, and photodisinfection. Light interactions with materials and biological tissues are complex and it is important to understand the advantages and limitations of these interactions for successful treatment outcomes. This article highlights the advent of photonic technologies in dentistry, its applications, the advantages and limitations, and possible future developments.

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Section: Transillumination and Fluorescencementioning

confidence: 99%

The power of light – From dental materials processing to diagnostics and therapeutics

A. Hadis,

Shortall,

M. Palin

2024

BIiD

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“…A clinical study showed that LC Rinse can distinguish between active caries, inactive caries, and hypomineralization, and can augment caries detection with high sensitivity, specificity, and diagnostic accuracy [162].…”

Section: Fluorescent Starch Nanoparticlesmentioning

confidence: 99%

Detection, Diagnosis, and Monitoring of Early Caries: The Future of Individualized Dental Care

Abdelaziz

2023

Diagnostics

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Dental caries remains a significant global health issue. It was highlighted by the World Health Organization’s 2022 reports that despite the efforts and scientific advancements in caries detection and management, the situation has only marginally improved over the past three decades. The persistence of this problem may be linked to outdated concepts developed almost a century ago but are still guiding dentists’ approach to caries management today. There is a need to reconsider professional strategies for preventing and managing the disease. Contemporary dentistry could benefit from embracing new concepts and technologies for caries detection and management. Dentists should explore, among others, alternative methods for caries detection such as optical-based caries detection. These tools have been established for over a decade and they align with current disease understanding and international recommendations, emphasizing early detection and minimally invasive management. This narrative review presents the current state of knowledge and recent trends in caries detection, diagnosis, monitoring, and management, offering insights into future perspectives for clinical applications and research topics.

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“…Thank you very much for giving us an opportunity to publish our work [ 1 ] in this high quality and internationally renowned peer-reviewed journal, BDJ Open , and for allowing us to respond to the letter from Dr Chris Longbottom.…”

mentioning

confidence: 99%