Evaluation of a novel point-of-care system, the i-STAT portable clinical analyzer

Abstract

We evaluated a novel system designed for rapid, point-of-care measurement of sodium, potassium, chloride, urea nitrogen, glucose, and hematocrit. The i-STAT Portable Clinical Analyzer (PCA) system is composed of a hand-held analyzer and disposable cartridges. Sample analysis takes place in the cartridge, which contains a series of thin-film electrodes microfabricated on silicon chips. The PCA was evaluated for precision, accuracy, and utility in emergency department and stat laboratory settings. Precision did not differ significantly between these two locations, the CVs being as follows: sodium, 0.46-0.89%; potassium, 1.06-1.45%; chloride, 0.69-2.76%; urea nitrogen, 2.54-6.12%; and glucose, 4.39-5.19%. The assessment of accuracy was based on comparison of patients' sample values analyzed by the PCA and the Kodak Ektachem 700 (or the Coulter ST for hematocrit). Regression statistics were acceptable for all analytes except chloride, for which the regression data were influenced by the limited range of results. A difference plot of the chloride comparison showed that the bias rarely exceeded 5 mmol/L. Mean hematocrit values significantly differed between the PCA and the Coulter ST, apparently because of different calibration procedures.

Prognostic Value of Plasma L-Lactate Concentration Measured Cow-Side with a Portable Clinical Analyzer in Holstein Dairy Cattle with Abomasal Disorders

“…The accuracy of the portable clinical analyzer used in this study has been verified in humans. [51][52][53] In cats, dogs, and horses; sodium, potassium, chloride, blood urea nitrogen (BUN), glucose, ionized calcium, hematocrit, pH, HCO 3 , base excess, lactate, pCO 2 , and pO 2 values measured using the PCA correlate to values obtained by standard laboratory techniques. [54][55][56] Unfortunately, the PCA has not been investigated in cows.…”

Comparison of theEPOCand i‐STATanalysers for canine blood gas and electrolyte analysis

“…*P<0·001. The i-STAT is a POC analyser which has proven analytical performance in humans (Erickson et al 1993). In dogs, it shows good correlation with standard laboratory analysers for blood gases and electrolytes (Grosenbaugh et al 1998, Looney et al 1998, Matburger et al 2000, Verwaerde et al 2002.…”

Effects of different capture techniques on the physiological condition of bonefishAlbula vulpesevaluated using field diagnostic tools

“…In human and veterinary medicine, many new innovations in 'point-of-care' diagnostic tools have recently been developed that can be applied in a physician's or veterinarian's office or in the home of a patient, providing nearly immediate results and obviating the need to send samples to an external laboratory for analysis (St-Louis, 2000). These tools have been extensively tested for humans (Erickson & Wilding, 1993;Jacobs et al, 1993;Pyne et al, 2000) and domestic animals (cats and dogs; Grosenbaugh et al, 1998;Looney et al, 1998;Cohn & McCaw, 2000;Wess & Rausch, 2000) but have only recently been tested for their applicability to fisheries research (Wells et al, 2003;Kojima et al, 2004;Mandelman & Farrington, 2007), aquaculture (Wells & Pankhurst, 1999;Venn Beecham et al, 2006) and aquatic animal medicine (Harrenstien et al, 2005). This type of approach would allow fisheries scientists to collect physiological data at field sites (e.g.…”