Evaluation of a point‐of‐care coagulation analyzer (Abaxis VSPro) for identification of coagulopathies in dogs

Dixon-Jimenez, Amy; Brainard, Benjamin M.; Cathcart, Curtis J.; Koenig, Amie

doi:10.1111/vec.12064

Cited by 25 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CoaguChek-XS had a higher sensitivity, but lower specificity compared to the SCA-2000, and a lower correlation to reference method compared to the Abaxis (r = 0.35 versus 0.578). 11,12 Routine oral anti-coagulant treatment is uncommonly practiced in dogs, although in certain cases (eg, treatment for aortic thromboembolism 21 and following heart valve replacement surgery 14,15 ) long-term warfarin therapy may be indicated in dogs. In such instances, home PT monitoring using the device may be considered.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9][10] Such devices are also penetrating the veterinary market, and 2 POC coagulation analyzers have been evaluated in dogs. 11,12 The CoaguChek-XS a is a second-generation, portable, battery-powered, laser photometer, weighing 175 g (batteries included) and fits in a human hand ( Figure 1). It uses a thromboplastin and iron particlecontaining test cartridge, which is inserted into a slot in the analyzer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of a portable prothrombin time analyzer (CoaguChek‐XS) in dogs

Kelmer

Segev

Codner

et al. 2014

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of a portable prothrombin time analyzer (CoaguChek‐XS) in dogs

Kelmer

Segev

Codner

et al. 2014

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…Dixon‐Jimenez et al evaluated a different POC coagulation analyser (Abaxis VSPro) in experimentally induced coagulopathic dogs that received unfractionated heparin . They calculated sensitivity 72% and specificity 86% for PT; and sensitivity 93% and specificity 89% for aPTT.…”

Section: Discussionmentioning

confidence: 99%

“…All previous studies involve the comparison of two different analysers, one being a POC analyser, the other a reference laboratory analyser . The reference laboratories’ coagulation analysers used in these studies include Kontact Pacific Hemostasis, Trinity AMAX destiny coagulation analyser Diamond Diagnostics 7 and ACL 200 Instrumentation Laboratory .…”

Section: Discussionmentioning

confidence: 99%

Agreement of point‐of‐care prothrombin and activated partial thromboplastin time in dogs with a reference laboratory

et al. 2018

View full text Add to dashboard Cite

Objectives To determine the agreement, sensitivity, specificity and accuracy of prothrombin (PT) and activated partial thromboplastin time (aPTT) using the point‐of‐care analyser SCA2000™ with IDEXX Coag Dx™ cartridges against a reference laboratory (STAGO Start 4®) in canine blood. Methods Citrated blood samples from 47 dogs were submitted for PT and aPTT measurements. The STAGO was taken as the gold standard and sensitivity, specificity and accuracy were calculated. Agreement between the IDEXX and STAGO test results was compared using Bland‐Altman analysis and Passing‐Bablok regression. Results The IDEXX cartridges had a sensitivity of 92% (95% confidence interval (CI) 62–100%) and specificity of 98% (95% CI 87–100%; n = 54 samples). aPTT sensitivity was 100% (95% CI 63–100%) and specificity was 47% (95% CI 30–65%, n = 42 samples). The accuracy of IDEXX cartridges compared with the STAGO Start 4 was 96% (95% CI 91–100%) for PT and 57% (95% CI 42–72%) for aPTT. Agreement was moderate–good for PT measurements within the reference range (RR). Agreement was poor for PT measurements outside of the RR and for aPTT measurements within and outside the RR. The bias between measurements from the two machines was inconsistent. Conclusions PT results from the point‐of‐care IDEXX were generally reliable for diagnosing or excluding a coagulopathy. The aPTT IDEXX sensitivity was excellent but the specificity was poor. Bland‐Altman analysis and Passing‐Bablok regression indicated an inconsistent bias between the two measurements and one measurement cannot be reliably converted to the other.

show abstract

“…In addition, point-of-care analysers with test cartridges for PT and APTT are available for animals (e.g., VetScan VSpro Coagulation Analyzer; Abaxis Europe, Darmstadt, Germany). A recent study demonstrated an acceptable correlation with conventional PT and APTT assays (Dixon-Jimenez et al, 2013).…”

Section: Blood Coagulation Tests (Global Tests Group Tests)mentioning

confidence: 99%

Laboratory evaluation and interpretation of haemostasis in small animals

Mischke

2017

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

This review deals with indications for performing haemostasis tests, methodical aspects of blood sampling and handling of sample material, selection of appropriate tests and basic principles of test interpretation. Indications for laboratory evaluation of haemostasis in small animals include spontaneous bleeding or bleeding disproportionate to the degree of trauma, bleeding from multiple sites and diseases which are frequently associated with haemostatic disorders. Patient history and clinical findings can deliver clues for the type of haemorrhagic diathesis. Important preanalytical issues include prevention of prolonged venous stasis, order of drawing and appropriate filling of the collection tubes and careful mixing of blood with anticoagulant. Initial screening can be performed by global tests of haemostasis including viscoelastic testing using thrombelastography and rotation thrombelastometry and/or a "basic examination profile" including platelet count, capillary bleeding time (optional in cases of suspected functional platelet disorders) and group tests prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin (clotting) time (optionally in cases of prolonged PT and APTT). This procedure allows a rational evaluation of the haemostatic system and a specific use of further tests including individual coagulation factor activities, inhibitor activities, activation markers, examination of von Willebrand factor, and platelet function analyses. It is important (1) to use species-and method specific reference values for interpretation and (2) to consider the limitations of tests when performed according to the standard test procedure optimised for human sample material (e.g., low sensitivity of PT test for canine and feline samples).

show abstract

Evaluation of a point‐of‐care coagulation analyzer (Abaxis VSPro) for identification of coagulopathies in dogs

Abstract: The Abaxis VSPro showed acceptable correlation with clinical laboratory tests, and is a useful POC device for identification of animals with abnormalities in PT or aPTT.

Cited by 25 publications

References 9 publications

Assessment of a portable prothrombin time analyzer (CoaguChek‐XS) in dogs

Assessment of a portable prothrombin time analyzer (CoaguChek‐XS) in dogs

Agreement of point‐of‐care prothrombin and activated partial thromboplastin time in dogs with a reference laboratory

Laboratory evaluation and interpretation of haemostasis in small animals

Contact Info

Product

Resources

About