2018
DOI: 10.1016/j.ihj.2017.07.001
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of a polymorphism in MYBPC3 in patients with anthracycline induced cardiotoxicity

Abstract: Cardiotoxicity is the most serious side effect of anthracyclines (doxorubicin, daunorubicin or epirubicin). The incidence of anthracycline induced late cardiac toxicity (AIC) that is overt clinically is 3-5% in the Indian population. Polymorphism in intron 32 (deletion of 25bp) of MYBPC3 has been shown to be present exclusively in Asians and more so in South India (3-8%). The frequency of the polymorphism is significantly higher (13%) in patients with cardiomyopathy in India. Fifteen patients were identified t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(1 citation statement)
references
References 15 publications
0
1
0
Order By: Relevance
“…Many of these studies were limited by small sample size and identified no significant SNPs. [11][12][13][14][15][16][17][18][19][20][21][22] Among CGAS that identified significant variants, candidate genes were related to drug metabolism (CBR3, 23 UGT1A6, 24,25 and POR 26 ), drug transport (SLC28A3, 25,27 SLC22A17, 28 SLC22A7, 28 ABCC2, 29 ABCC1, [30][31][32] ABCC5, 33 and ABCG2 34 ), iron metabolism (HFE 29,35 ), cell signalling (RAC2, 29,31 NOS3, 33 and PLCE1 36 ), DNA repair (ERCC2, 37 BRCA1, 38 and BRCA2 38 ), splicing regulation (CELF4 24 ), response to oxidative stress (CAT, 39 NCF4, 31,40,41 GSTP1, 42 and CYBA 31,41 ), calcium homeostasis (ATP2B1 36 ), myosin synthesis (MYH7 43 ), and extracellular matrix synthesis (HAS3 24,44 ). Additionally, two exome array analyses identified candidate genes (ETFB 45 and GPR35 46 ) that were significant only when analysed with a gene-based approach.…”
Section: 1 Anthracyclinesmentioning
confidence: 99%
“…Many of these studies were limited by small sample size and identified no significant SNPs. [11][12][13][14][15][16][17][18][19][20][21][22] Among CGAS that identified significant variants, candidate genes were related to drug metabolism (CBR3, 23 UGT1A6, 24,25 and POR 26 ), drug transport (SLC28A3, 25,27 SLC22A17, 28 SLC22A7, 28 ABCC2, 29 ABCC1, [30][31][32] ABCC5, 33 and ABCG2 34 ), iron metabolism (HFE 29,35 ), cell signalling (RAC2, 29,31 NOS3, 33 and PLCE1 36 ), DNA repair (ERCC2, 37 BRCA1, 38 and BRCA2 38 ), splicing regulation (CELF4 24 ), response to oxidative stress (CAT, 39 NCF4, 31,40,41 GSTP1, 42 and CYBA 31,41 ), calcium homeostasis (ATP2B1 36 ), myosin synthesis (MYH7 43 ), and extracellular matrix synthesis (HAS3 24,44 ). Additionally, two exome array analyses identified candidate genes (ETFB 45 and GPR35 46 ) that were significant only when analysed with a gene-based approach.…”
Section: 1 Anthracyclinesmentioning
confidence: 99%