Evaluation of a polysaccharide-based chiral reversed-phase liquid chromatography screen strategy in pharmaceutical analysis

Sensitivity enhancement in capillary electrophoresis and their applications for analyses of pharmaceutical and related biochemical substances

“…Therefore, many ion sources have been developed to achieve this transition. The most commonly used ionization technique for liquid samples is ESI [5–49]. The integrated two‐phase electroextraction (EE), CE, and MS combine rapid sample extraction to enable high‐performance separation and sensitive detection of metabolites (i.e., leucine, isoleucine, adenosine, phenylalanine, and guanosine).…”

“…Chemical factors affecting CEseparations efficiency are the buffer, organic modifiers, and additives [27][28][29][30][31][32]. Increasing buffer concentrations at a given pH decreases the EOF and solute velocity [33,34], while alterations of buffer pH can affect separation by modifying the charge of an analyte and the EOF.…”

Recent Advances in Chiral Analysis of Proteins and Peptides

“…Commercial cellulose-and amylose-based columns are most popular, however synthesized columns based on chitosan, xylan, curdlan, dextran and inulin may also be found [73]. Indeed, Lin et al have evaluated 17 amylose and cellulose-based columns, both coated and immobilized, for chiral pharmaceutical analysis [74]. Different types of cellulose and amylose-based chiral selectors and their derivatives, the effect of substituents and carrier on properties of polysaccharide-based CSPs, and optimizations of the CSP and the mobile phase for separation of enantiomers by high-performance liquid chromatography (HPLC) have been summarized by Chankvetadze [75].…”

Hybridization of helical poly(phenylacetylene)s bearing l-proline tripeptide pendants into porous silica microspheres as a solvent-tolerable chiral stationary phase for liquid chromatography

“…7,8 Looking beyond polysaccharide-based CSPs, some synthetic optically active polymers can also exhibit excellent chiral recognition ability, and they have been used in the analysis and separation of enantiomers. [9][10][11][12][13][14] In multitudinous synthetic optically active polymers, one-handed helical poly ( phenylacetylene) has attracted extensive attention because of its particular helical structure and properties. [15][16][17][18] In previous studies, we designed and prepared various onehanded helical poly( phenylacetylene) polymers with amino acid groups and their corresponding coated-type CSPs, which demonstrated excellent enantiomer resolution ability.…”

“…7,8 Looking beyond polysaccharide-based CSPs, some synthetic optically active polymers can also exhibit excellent chiral recognition ability, and they have been used in the analysis and separation of enantiomers. 9–14 In multitudinous synthetic optically active polymers, one-handed helical poly(phenylacetylene) has attracted extensive attention because of its particular helical structure and properties. 15–18…”