2016
DOI: 10.1001/jamacardio.2016.3366
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Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records

Abstract: Importance Atrial fibrillation contributes to substantial morbidity, mortality, and healthcare expenditures. Accurate prediction of incident atrial fibrillation would enhance patient management and potentially improve outcomes. Objective We aimed to validate the atrial fibrillation risk prediction model originally developed by the CHARGE-AF investigators utilizing a large repository of electronic medical records. Design Using a database of de-identified medical records, we conducted a retrospective electro… Show more

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Cited by 51 publications
(33 citation statements)
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“…Second, these risk models could be used as a research tool to adjust for case mix, thus providing a standardized comparison between different study populations, which is relevant for both researchers and health care administrators. 32 However, such speculations are hypothesis generating only, and the specific merits of the application of the cardiac-specific comorbidity index should be evaluated by further research.…”
Section: Discussionmentioning
confidence: 99%
“…Second, these risk models could be used as a research tool to adjust for case mix, thus providing a standardized comparison between different study populations, which is relevant for both researchers and health care administrators. 32 However, such speculations are hypothesis generating only, and the specific merits of the application of the cardiac-specific comorbidity index should be evaluated by further research.…”
Section: Discussionmentioning
confidence: 99%
“…These AF risk scores derived from prospective cohort studies may have poor calibration. 12 The widespread availability of electronic health records (EHRs) that include real-world data from large numbers of patients offers an opportunity for the development and validation of risk models using large numbers of individuals, frequently greatly exceeding sample sizes available in individual trials or prospective cohorts of limited generalizability. 13 Implicit in the use of an EHR-based score, is the availability of the data to the primary physician to support decision making without further testing.…”
Section: Introductionmentioning
confidence: 99%
“…With these challenges in mind, the electronic medical record repositories may be of value in assessing response to risk factor modification. These can serve as an inexpensive and efficient complement to community cohort studies not only for the development of prediction models17 but also prospectively evaluating AF risk factor modification. Furthermore, given that electronic medical records are integrated into clinical practice, prediction models could be incorporated into these systems to prospectively identify individuals at high risk for AF with the ultimate goal of developing individualized preventive strategies.…”
mentioning
confidence: 99%