Evaluation of a prescreening blood donor program for prevention of perinatal transfusion-acquired cytomegalovirus (CMV) infection

Bhumbra, Nasreen A.; Lewandowski, Patricia; Lau, Peter; Sererat, Marasri; Satish, Malini; Nankervis, George A.

doi:10.1515/jpme.1988.16.2.127

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…In all CMV-TTI, the diagnosis was made through the DNA virus detection in pharyngeal swabs and urine (10 patients), and bloodstream (5 patients). Each patient received a median number of 5.5 RBC units (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Four patients were also given PLT (2 patients) or plasma (2 patients) transfusions.…”

Section: Five-year Experience At Our Neonatologymentioning

confidence: 99%

“… Phase 2: 439 /RBC, CMV IgM was performed on the day of donation: only CMV IgM negative donors were used. NA Bhumbra et al [ 9 ] Newborns with BW < 2,000g Total enrolled 137: 137/RBC 13/fresh frozen plasma Not specified/granulocyte At beginning, all donors were seronegative but 16 (0.7 %) seroconverted during the study. All mothers were seronegative Two infants developed CMV infection and viruria after each received CMV seropositive blood (these units were mistakenly identified as CMV seronegative due to technical errors or poor sensitivity of the test kit).…”

Section: Literature Reviewmentioning

confidence: 99%

“…In Table 1 , we reported CMV infection in neonates undergoing blood transfusions in a wide range of years with different transfusion practices [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ]. Transfusions and viral shedding in the milk of seropositive mothers are the two main routes implicated in transmitting post-natal CMV infection.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Several papers showed that blood components from CMV-seropositive donors are potentially the major cause of CMV infections in neonates. Testing CMV status of the donor is the most effective strategy in preventing transfusion-associated CMV infection [ [3] , [4] , [5] , [8] , [9] , [10] , [11] ]. Moreover, exposing neonates to a low number of donors may be also preventive [ 2 , 6 , 8 ].…”

Section: Literature Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Bianchi

Orlando

Valentini

et al. 2020

Transfusion and Apheresis Science

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Neonates and prematures are among the most transfused categories of patients. Adverse reactions due to transfusions, such as transfusion-transmitted infections, can affect the rest of their lives. In this systematic review, we revised the literature concerning transfusion-transmitted infection in neonates. We reported casereports and case-series previously published and we integrated these data with our experience at local neonatal intensive care unit. Moreover, we illustrated strategies for mitigating transfusion-transmitted infections, including donor selection and testing, pathogen inactivation technologies and combined approaches, as for Cytomegalovirus infection, integrating leukoreduction and identification of seronegative donors.

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Section: Five-year Experience At Our Neonatologymentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Bianchi

Orlando

Valentini

et al. 2020

Transfusion and Apheresis Science

View full text Add to dashboard Cite

show abstract

Retrieval of Placental Blood From the Umbilical Vein to Determine Volume, Sterility, and Presence of Clot Formation

Anderson

Fangman

Wager

et al. 1992

Arch Pediatr Adolesc Med

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Multipotent mesenchymal stromal cells are fully permissive for human cytomegalovirus infection

et al. 2016

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Congenital human cytomegalovirus (HCMV) infection is a leading infectious cause of birth defects. Previous studies have reported birth defects with multiple organ maldevelopment in congenital HCMV-infected neonates. Multipotent mesenchymal stromal cells (MSCs) are a group of stem/progenitor cells that are multi-potent and can self-renew, and they play a vital role in multi-organ formation. Whether MSCs are susceptible to HCMV infection is unclear. In this study, MSCs were isolated from Wharton's jelly of the human umbilical cord and identified by their plastic adherence, surface marker pattern, and differentiation capacity. Then, the MSCs were infected with the HCMV Towne strain, and infection status was assessed via determination of viral entry, replication initiation, viral protein expression, and infectious virion release using western blotting, immunofluorescence assays, and plaque forming assays. The results indicate that the isolated MSCs were fully permissive for HCMV infection and provide a preliminary basis for understanding the pathogenesis of HCMV infection in non-nervous system diseases, including multi-organ malformation during fetal development.

show abstract

Evaluation of a prescreening blood donor program for prevention of perinatal transfusion-acquired cytomegalovirus (CMV) infection

Cited by 10 publications

References 9 publications

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Infectious complications in neonatal transfusion: Narrative review and personal contribution

Retrieval of Placental Blood From the Umbilical Vein to Determine Volume, Sterility, and Presence of Clot Formation

Multipotent mesenchymal stromal cells are fully permissive for human cytomegalovirus infection

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