Evaluation of a procedure to measure the time course of a drug's behavioral action

Schlinger, Henry D.; Poling, Alan

doi:10.1016/0160-5402(88)90077-0

Cited by 1 publication

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“…The procedure was similar to that described in detail by Schlinger and Poling (1988). In brief, pigeons trained to peck the response key for access to food were exposed to 12-h overnight sessions that were conducted four times per week, Monday through Thursday.…”

Section: Methodsmentioning

confidence: 99%

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

Koek

Mercer

Coop

2009

J Pharmacol Exp Ther

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␥-Hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not entirely clear, although GABA B receptors seem to play an important role. This role could be complex, because there are indications that different GABA B receptor mechanisms mediate the effects of GHB and the prototypical GABA B receptor agonist baclofen. To further explore possible differences in underlying GABA B receptor mechanisms, the present study examined the effects of GHB and baclofen on operant responding and their antagonism by the GABA B receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348). Pigeons were trained to peck a key for access to food during response periods that started at different times after the beginning of the session. In these pigeons, GHB, its precursor ␥-butyrolactone (GBL), and the GABA B receptor agonists baclofen and 3-aminopropyl(methyl)phosphinic acid hydrochloride (SKF97541) decreased the rate of responding in a dose-and time-dependent manner. CGP35348 shifted the dose-response curve of each agonist to the right, but the magnitude of the shift differed among the agonists. Schild analysis yielded a pA 2 value of CGP35348 to antagonize GHB and GBL [i.e., 3.9 (3.7-4.2)] that was different (P ϭ 0.0011) from the pA 2 value to antagonize baclofen and SKF97541 [i.e., 4.5 (4.4 -4.7)]. This finding is further evidence that the GABA B receptor mechanisms mediating the effects of GHB and prototypical GABA B receptor agonists are not identical. A better understanding of the similarities and differences between these mechanisms, and their involvement in the therapeutic effects of GHB and baclofen, could lead to more effective medications with fewer adverse effects.

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Section: Methodsmentioning

confidence: 99%

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

Koek

Mercer

Coop

2009

J Pharmacol Exp Ther

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Evaluation of a procedure to measure the time course of a drug's behavioral action

Cited by 1 publication

References 5 publications

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

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Evaluation of a procedure to measure the time course of a drug's behavioral action

Cited by 1 publication

References 5 publications

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABAB Receptor Agonists: Time Course and Differential Antagonism by the GABAB Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABAB Receptor Agonists: Time Course and Differential Antagonism by the GABAB Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

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Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)

Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABA_B Receptor Agonists: Time Course and Differential Antagonism by the GABA_B Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)