Evaluation of a Pulsed-Xenon Ultraviolet Room Disinfection Device for Impact on Hospital Operations and Microbial Reduction

Stibich, Mark; Stachowiak, Julie; Tanner, Benjamin D.; Berkheiser, Matthew; Moore, L. P.; Raad, Issam; Chemaly, Roy F.

doi:10.1086/658329

Cited by 82 publications

(66 citation statements)

References 7 publications

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“…Statistically significantly lower bacterial heterotrophic plate counts (HPCs) and no VRE were found in rooms after PX-UV treatment, suggesting that the risk to the next occupant from environmental contamination was correspondingly lower. The study also found that the PX-UV disinfection system is quick enough to be integrated into daily hospital operations without adversely affecting patient throughput (49). Further, the treatment leaves no residual compounds and chemicals behind that can cause ecological problems and/or are potentially harmful to humans.…”

Section: One Technology That Could Potentially Be Used With Traditionmentioning

confidence: 85%

Technology and the Future of Intensive Care Unit Design

Rashid

2011

Critical Care Nursing Quarterly

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Changing market demand, aging population, severity of illnesses, hospital acquired infection, clinical staff shortage, technological innovations, and environmental concerns-all are shaping the critical care practice in the US today. However, how these will shape Intensive Care Unit (ICU) design in the coming decade is anybody's guess. In a Graduate Architecture Studio of a research university, students were asked to envision the ICU of the future while responding to the changing needs of the critical care practice through innovative technological means. This paper reports the ICU design solutions proposed by these students.

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Section: One Technology That Could Potentially Be Used With Traditionmentioning

confidence: 85%

Technology and the Future of Intensive Care Unit Design

Rashid

2011

Critical Care Nursing Quarterly

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“…8,11 In addition, our study provides 2 assessments not included in previous publications on PX-UV (ie, log reductions achieved by PX-UV on carriers and a comparison with continuous UV). Although the log reductions achieved by PX-UV on carriers at 10 minutes were relatively modest, this exposure time was sufficient to reduce contamination on real-world surfaces.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Mercury gas bulbs primarily emit UV-C at 254 nm, whereas xenon gas bulbs produce a broad spectrum of radiation that encompasses the UV (100-280 nm) and visible (380-700 nm) spectra. [8][9][10][11][12] The UV-C radiation emitted by low pressure mercury bulbs is delivered in a continuous stream that gradually accumulates to lethal doses depending on duration of exposure and distance from the primary field of radiation. [1][2][3][4][5][6][7] The broad-range UV delivered by xenon bulbs is emitted in short, high-intensity pulses, possibly requiring a shorter duration of exposure to achieve lethal doses.…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6][7] The broad-range UV delivered by xenon bulbs is emitted in short, high-intensity pulses, possibly requiring a shorter duration of exposure to achieve lethal doses. [8][9][10][11][12] Given the increasing use of UV devices and variations in recommended cycle times, there is a need for evaluations of the real-world performance and comparative effectiveness of different devices. We previously demonstrated that a mobile, automated room disinfection device that utilizes mercury bulbs for emitting UV-C radiation is effective for reducing the frequency of positive methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and Clostridium difficile culture results on high-touch surfaces in hospital rooms (Tru-D Rapid Room Disinfection device; Lumalier).…”

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confidence: 99%

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Evaluation of a Pulsed Xenon Ultraviolet Disinfection System for Reduction of Healthcare-Associated Pathogens in Hospital Rooms

Nerandzic

Thota

Sankar

et al. 2015

Infect. Control Hosp. Epidemiol.

109

121

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objective. To determine the effectiveness of a pulsed xenon ultraviolet (PX-UV) disinfection device for reduction in recovery of healthcareassociated pathogens.setting. Two acute-care hospitals.methods. We examined the effectiveness of PX-UV for killing of Clostridium difficile spores, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) on glass carriers and evaluated the impact of pathogen concentration, distance from the device, organic load, and shading from the direct field of radiation on killing efficacy. We compared the effectiveness of PX-UV and ultraviolet-C (UV-C) irradiation, each delivered for 10 minutes at 4 feet. In hospital rooms, the frequency of native pathogen contamination on high-touch surfaces was assessed before and after 10 minutes of PX-UV irradiation.results. On carriers, irradiation delivered for 10 minutes at 4 feet from the PX-UV device reduced recovery of C. difficile spores, MRSA, and VRE by 0.55 ± 0.34, 1.85 ± 0.49, and 0.6 ± 0.25 log 10 colony-forming units (CFU)/cm 2 , respectively. Increasing distance from the PX-UV device dramatically reduced killing efficacy, whereas pathogen concentration, organic load, and shading did not. Continuous UV-C achieved significantly greater log 10 CFU reductions than PX-UV irradiation on glass carriers. On frequently touched surfaces, PX-UV significantly reduced the frequency of positive C. difficile, VRE, and MRSA culture results.conclusions. The PX-UV device reduced recovery of MRSA, C. difficile, and VRE on glass carriers and on frequently touched surfaces in hospital rooms with a 10-minute UV exposure time. PX-UV was not more effective than continuous UV-C in reducing pathogen recovery on glass slides, suggesting that both forms of UV have some effectiveness at relatively short exposure times. 2015;36(2):192-197 Automated room disinfection technologies are increasingly being used as an adjunct to standard cleaning and disinfection in healthcare facilities. Ultraviolet (UV) radiation devices have been most widely adopted owing to the efficiency and welldocumented efficacy of UV irradiation. Infect Control Hosp Epidemiol1-7 Several UV room disinfection devices are now being marketed. Most of these devices use low pressure mercury gas bulbs, but recently pulsed xenon flash bulbs have also been incorporated into disinfection systems. UV radiation has peak germicidal effectiveness in the wavelength range from 240 to 280 nm.

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“…Germicidal UV irradiation has been shown to be effective in deactivating C. difficile endospores in laboratory and clinical settings (Nerandzic et al, 2010;Rutala et al, 2010;Stibich et al, 2011). Specifically, the UV-C frequency, which ranges from 200 to 280 nm, is known to have germicidal properties through a variety of mechanisms, including photodimerization, photohydration, photo cross-linking, and photoseparation (Rutala et al, 2010;Stibich et al, 2011).…”

Section: Introductionmentioning

confidence: 99%