Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis

Juárez-Figueroa, Luis; Uribe-Salas, Felipe; García-Cisneros, Santa; Olamendi-Portugal, María; Conde-Glez, Carlos J.

doi:10.1016/j.diagmicrobio.2007.04.008

Cited by 17 publications

(22 citation statements)

References 10 publications

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“…The overall specificity results reported here were similar for the Elecsys syphilis assay and all other assays tested (Table 2) and compare favorably with those reported in the literature (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), as shown in Fig. 1A.…”

Section: Discussionsupporting

confidence: 89%

Performance Evaluation of the Elecsys Syphilis Assay for the Detection of Total Antibodies to Treponema pallidum

Enders¹,

Hunjet²,

Gleich

et al. 2015

Clin Vaccine Immunol

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Syphilis is a health problem of increasing incidence in recent years that may have severe complications if not diagnosed and treated at an early stage. There are many diagnostic tests available for syphilis, but there is no gold standard, and diagnosis therefore usually relies upon a combination of tests. In this multicenter study, we evaluated the treponemal Elecsys syphilis assay for use in the diagnosis of syphilis in routine samples, i.e., when syphilis is suspected or during antenatal or blood donation screening. The sensitivity and specificity of the Elecsys syphilis assay were compared head to head with those of other treponemal assays used in routine clinical practice and were assessed in potentially cross-reactive samples from patients with Epstein-Barr virus, HIV, and Lyme disease. In a total of 8,063 syphilis-negative samples collected from routine diagnostic requests and blood donations, the Elecsys syphilis assay had a specificity of 99.88%. In 928 samples previously identified as syphilis positive, the sensitivity was 99.57 to 100% (the result is presented as a range depending on whether four initially indeterminate samples are included in the assessment). The specificity of the Elecsys syphilis assay in patients with other infections was 100%; no false-positive samples were identified.

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Section: Discussionsupporting

confidence: 89%

Performance Evaluation of the Elecsys Syphilis Assay for the Detection of Total Antibodies to Treponema pallidum

Enders¹,

Hunjet²,

Gleich

et al. 2015

Clin Vaccine Immunol

View full text Add to dashboard Cite

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“…Completion rate of POC testing was high in two studies [20, 23], as patient and provider satisfaction were reported with POC testing in one study [38]. Clinicians and laboratory staff found use and interpretation of results easy [4, 17, 19, 22, 35, 37]. In six studies, a reduction in turnaround time to testing and obtaining results was well received [16, 18, 19, 23, 35, 38].…”

Section: Resultsmentioning

confidence: 99%

“…From the providers' perspective, challenges included a lack of confidence in POC test results due to the inability to differentiate between past and present infections leading to overtreatment [16, 17, 19, 35]. In addition, disagreements between test readers [37], suboptimal field conditions [34], unreadable [36] or difficulty reading results [39], concerns over procurement of POC tests [38], and the time-consuming nature of offering one-stop services with POC [19, 38] posed challenges in delivery of these services. Furthermore, not all patients agreed to undergo confirmation testing [27], hampering ideal execution of testing process.…”

Section: Resultsmentioning

confidence: 99%

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Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework

Jafari

Johri

Joseph

et al. 2014

AIDS Research and Treatment

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Background. Point-of-care (POC) diagnostics for syphilis can contribute to epidemic control by offering a timely knowledge of serostatus. Although accuracy data on POC syphilis tests have been widely published, few studies have evaluated broader outcomes beyond accuracy that impact patients and health systems. We comprehensively reviewed evidence and reporting of these implementation research outcomes (IROs), and proposed a framework to improve their quality. Methods. Three reviewers systematically searched 6 electronic databases from 1980 to 2014 for syphilis POC studies reporting IROs. Data were abstracted and findings synthesised narratively. Results. Of 71 studies identified, 38 documented IROs. IROs were subclassified into preference (7), acceptability (15), feasibility (15), barriers and challenges (15), impact (13), and prevalence (23). Using our framework and definitions, a pattern of incomplete documentation, inconsistent definitions, and lack of clarity was identified across all IROs. Conclusion. Although POC screening tests for syphilis were generally favourably evaluated across a range of outcomes, the quality of evidence was compromised by inconsistent definitions, poor methodology, and documentation of outcomes. A framework for standardized reporting of outcomes beyond accuracy was proposed and considered a necessary first step towards an effective implementation of these metrics in POC diagnostics research.

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“…Treponemal-specific IgM and IgG antibodies are usually generated two and four weeks after infection, respectively [4], appearing earlier than nontreponemal antibodies. The IgM antibody may persist and does not disappear, even if the patient receives adequate treatment [5,6]. Moreover, reaginic antibodies may be negative in cases of late, latent, or post-treatment syphilis (due to seroreversion) [7].…”

mentioning

confidence: 99%

A better definition of active syphilis infection

Chen

Qiu

Zhang

et al. 2015

Clinica Chimica Acta

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Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis

Cited by 17 publications

References 10 publications

Performance Evaluation of the Elecsys Syphilis Assay for the Detection of Total Antibodies to Treponema pallidum

Performance Evaluation of the Elecsys Syphilis Assay for the Detection of Total Antibodies to Treponema pallidum

Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework

A better definition of active syphilis infection

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