Evaluation of a role of cytokine gene polymorphisms in development of bronchial asthma in the Republic of Bashkortostan

Карунас, А. С.; Федорова, Ю. Ю.; Рамазанова, Н. Н.; Галимова, Е. С.; Гималова, Г. Ф.; Гурьева, Л. Л.; Левашева, С. В.; Бикташева, А. Р.; Мухтарова, Л. А.; Загидуллин, Ш. З.; Эткина, Э. И.; Хуснутдинова, Э. К.

doi:10.18093/0869-0189-2012-0-5-37-40

Cited by 2 publications

(1 citation statement)

References 12 publications

(17 reference statements)

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“…However, there was a tendency to increase the proportion of allele C in the group of asthma patients (Kutlina et al, 2018). Nevertheless, polymorphic variants of the TNFA, IL4, and IL13 cytokine genes have been shown to contribute to the formation of a genetic predisposition to asthma in the Republic of Bashkortostan (Karunas et al, 2012).…”

Section: Genetic Markers Of Children Asthma: Predisposition To Diseas...mentioning

confidence: 99%

Genetic markers of children asthma: predisposition to disease course variants

et al. 2023

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Asthma is a heterogeneous and often difficult to treat condition that results in a disproportionate cost to healthcare systems. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life. An important therapeutic focus is to achieve disease control, which is supposed to involve a personalized approach to treatment of asthma of any severity. Asthma is a multifactorial disease with a significant genetic determinant, however, the inheritance of asthma has not been fully elucidated. Polymorphic genes of inflammatory mediators, including cytokines, play an important role in developing various disease forms. In the current study, large-scale original data on the prevalence of cytokine gene genotypes (IL2, IL4, IL5, IL6, IL10, IL12, IL13, IL17A, IL31, IL33, IFNG, TNFA) among Russian children with asthma in Krasnoyarsk region have been obtained. Genotyping was carried out using real-time PCR. We identified markers predisposing to the development of different variants of the course of childhood asthma: the CT genotype and T allele of IL4 rs2243250 are associated with asthma (p < 0.05), especially in mild asthma and in controlled asthma. The TT genotype and allele T of IL13 rs1800925 are associated with severe and uncontrolled asthma (p < 0.05). The AA genotype of IL17A rs2275913, the TT genotype of IFNG rs2069705 and allelic A variants of TNFA rs1800629 are associated with mild asthma, and the TT genotype of IFNG rs2069705 is additionally associated with controlled asthma. The results obtained will supplement information on the prevalence of polymorphic variants of the cytokine genes in the Russian population and in asthma patients with different disease courses, which is likely to be used in order to shape a plan for Public Health Authority to prevent the development of severe uncontrolled asthma and to optimize personalized therapy.

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Section: Genetic Markers Of Children Asthma: Predisposition To Diseas...mentioning

confidence: 99%

Genetic markers of children asthma: predisposition to disease course variants

et al. 2023

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Analysis of associations of polymorphisms in the genes coding for L4, IL10, IL13 with the development of atopic bronchial asthma and its remission

Zhorina

Abramovskikh

Игнатова

et al. 2019

BRSMU

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Bronchial asthma is a multifactorial disease underpinned by chronic inflammation. The atopic phenotype of BA implies the presence of similar molecular mechanisms of pathogenesis between the patients. The aim of this study was to analyze the associations between the development of atopic BA/its remission and the following polymorphisms of interleukin genes: IL4 (rs2243250; C-589T), IL10 (rs1800896; G-1082A; rs1800872; C-592A), and IL13 (rs20541; Arg130Gln). Using allele-specific polymerase chain reaction (PCR), we studied the listed SNPs in the mixed urban sample of patients with BA (n = 53) and the controls (n = 30) residing in South Ural. The analysis revealed that genotype АА of IL10 (rs1800872) occurred more frequently in the control group (23.3%) than in the patients with atopic BA (5.7%) (OR = 0.197; 95% CI [0.047–0.832]; р = 0.031). No differences in genotype frequencies were observed between the patients with atopic BA and the controls for other studied polymorphisms. Our study failed to demonstrate the association of the listed polymorphisms and BA remission.

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Evaluation of a role of cytokine gene polymorphisms in development of bronchial asthma in the Republic of Bashkortostan

Cited by 2 publications

References 12 publications

Genetic markers of children asthma: predisposition to disease course variants

Genetic markers of children asthma: predisposition to disease course variants

Analysis of associations of polymorphisms in the genes coding for L4, IL10, IL13 with the development of atopic bronchial asthma and its remission

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