Background: The study is located in Istanbul, Turkey, where more than 750,000 Syrian refugees reside, largely in urban settings. It develops and pilot tests a novel model for helping urban refugee families in settings with limited to no access to evidence-based mental health services for refugees, by delivering a transdiagnostic family intervention for common mental disorders in health and non-health sector settings using a task-sharing approach. This case study addresses the following question: How can we address the common mental disorders of both children and parents, and support protective family resilience processes, through a low intensity trans-diagnostic family support intervention? Discussion: The rapidly growing scale of humanitarian crises requires new response capabilities geared towards addressing populations with prolonged high vulnerability to mental health consequences and limited to no access to mental health, health, and social resources. We faced multiple challenges in conducting this research including: 1) identifying local academic partners with research capacity, including in implementation science; 2) lack of culture of partnership between academics and humanitarian organizations; 3) getting local clinicians to embrace on a task-sharing model; 4) cultural competency of local and U.S. partners for refugee population; 5) getting local academics to focus on humanitarian emergency; 6) planning for a family intervention that would work with families with rigid gender role perspectives; 7) multiple social and economic problems that could not be solved, such as children working; 8) engagement challenges due to high demands on families. Through the research process, the research team learned lessons concerning: 1) building a coalition of academic and humanitarian organization partners; 2) investing in research capacity building of local partners; 3) working in a community-collaborative and multi-disciplinary approach to best understand and address socio-cultural, contextual, practical and scientific challenges needed to develop and implement the new family support model. Conclusion: Conducting research in humanitarian emergency settings calls for significant attention to building a coalition of academic and humanitarian organization partners, investing in research capacity building of local partners, and working in a community-collaborative and multi-disciplinary approach.