Evaluation of a sensitive GC–MS method to detect polysorbate 80 in vaccine preparation

Shende, Niraj; Karale, Abhijeet; Bhagade, Sudhakar; Gulhane, Ashishkumar; Bore, Prashant; Marathe, Preeti; Chakraborty, Sourish; Mallya, Asha D.; Dhere, Rajeev

doi:10.1016/j.jpba.2020.113126

Cited by 6 publications

(1 citation statement)

References 22 publications

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“…In the above context, a fast and reliable method for the detection of paracetamol and aspirin in water bodies is a viable approach to monitor these two chemicals in various matrixes. Different analytical and spectroscopic methods like gas chromatography mass spectrometry (GC-MS) [24][25][26][27][28][29][30], high-performance liquid chromatography [31][32][33], and fluorescence spectroscopy [31,[34][35][36][37] are being used for such purposes. Some of these methods, such as GC-MS, are very accurate but not as rapid as spectroscopic techniques, requiring very long sample preparation time.…”

Section: Introductionmentioning

confidence: 99%

100 GSM paper as an SERS substrate for trace detection of pharmaceutical drugs in an aqueous medium

Sarma¹,

Biswas²,

Hatiboruah³

et al. 2022

J. Phys. D: Appl. Phys.

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Surface-enhanced Raman Spectroscopy (SERS) is a unique technique that allows us to detect samples in trace quantities. This nanomaterial assisted phenomenon has been extensively studied over past several decades for sensing various chemical, biological and gaseous samples. Present work demonstrates the working of a paper-based SERS substrate to detect and quantify two pharmaceutical drugs- paracetamol, and aspirin in water. The proposed paper-based SERS substrate has been obtained by drop-casting of silver nanoparticles (AgNPs) over a 100 grams per square meter (GSM) paper. The performance of the designed SERS substrate has been initially evaluated with two Raman active samples - malachite green (MG) and rhodamine-6G (R6G). Upon noticing its reliable performance, the usability of the designed SERS substrate has been demonstrated to detect and quantify paracetamol and aspirin in the water medium. The applicability of the proposed SERS substrate in the real field environment has also been demonstrated through detection of these two drug elements in field collected water samples.

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