Evaluation of a series of cases of langerhans cell histiocytosis by comparative genomic hybridization

Haag, M; Avet-Loiseau, H.; Favara, Blaise E.; Steele, Alex A.; Smith, Jaron A; Pallavicini, Maria G.

doi:10.1016/0165-4608(96)85293-9

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“…Attempts at cytogenetic studies have usually failed since lesional cells do not propagate in culture and direct preparations have not been rewarding in spite of high proliferative rates in some lesions. No evidence of somatic mutation has been found in the lesions of LCH using comparative genomic hybridization [30]. The use of growth factors in tissue cultures of material from lesions of LCH holds promise of more critical cytogenetic and molecular genetic information.…”

Section: Langerhans Cell Histiocytosis (Lch)mentioning

confidence: 99%

Contemporary classification of histiocytic disorders

Favara

Feller²,

Pauli³

et al. 1997

Med. Pediatr. Oncol.

741

195

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Pathologists and pediatric hematologist/oncologists of the World Health Organization's Committee on Histiocytic/Reticulum Cell Proliferations and the Reclassification Working Group of the Histiocyte Society present a classification of the histiocytic disorders that primarily affect children. Nosology, based on the lineage of lesional cells and biological behavior, is related to the ontogeny of histiocytes (macrophages and dendritic cells of the immune system). Dendritic cell‐related disorders of varied biological behavior are dominated by Langerhans cell histiocytosis, but separate secondary proliferations of dendritic cells must be differentiated. Juvenile xanthogranuloma represents a disorder of dermal dendrocytes, another dendritic cell of skin. The hemophagocytic syndromes are the most common of the macrophage‐related disorders of varied biological behavior. Guidelines for distinguishing the exceedingly rare malignant diseases of histiocytes from large cell lymphomas through the use of a battery of special studies are provided. Med. Pediatr. Oncol. 29:157–166, 1997. © 1997 Wiley‐Liss, Inc.

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Section: Langerhans Cell Histiocytosis (Lch)mentioning

confidence: 99%