Evaluation of a structural polymorphism in the ankyrin repeat and kinase domain containing 1 (ANKK1) gene and the activation of executive attention networks

Fossella, John; Green, Adam E.; Fan, Jin

doi:10.3758/cabn.6.1.71

Cited by 47 publications

(38 citation statements)

References 36 publications

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“…Later, a separate group replicated the maoa finding (Meyer-Lindenberg et al, 2006). In a follow-up study, we found individual differences in ACC activity that were associated with variation in a genetic marker linked to the dopamine d2 receptor (DRD2) (Fossella et al, 2006).…”

Section: Imaging-genetic Studies Of Attention Link Genotype To Cingulsupporting

confidence: 55%

Provisional hypotheses for the molecular genetics of cognitive development: Imaging genetic pathways in the anterior cingulate cortex

Fossella

Fan

Liu

et al. 2008

Biological Psychology

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Brain imaging genetic research involves a multitude of methods and spans many traditional levels of analysis. Given the vast permutations among several million common genetic variants with thousands of brain tissue voxels and a wide array of cognitive tasks that activate specific brain systems, we are prompted to develop specific hypotheses that synthesize converging evidence and state clear predictions about the anatomical sources, magnitude and direction (increases vs. decreases) of allele-and task-specific brain activity associations. To begin to develop a framework for shaping our imaging genetic hypotheses, we focus on previous results and the wider imaging genetic literature. Particular emphasis is placed on converging evidence that links system-level and biochemical studies with models of synaptic function. In shaping our own imaging genetic hypotheses on the development of Attention Networks, we review relevant literature on core models of synaptic physiology and development in the anterior cingulate cortex.

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Section: Imaging-genetic Studies Of Attention Link Genotype To Cingulsupporting

confidence: 55%

Provisional hypotheses for the molecular genetics of cognitive development: Imaging genetic pathways in the anterior cingulate cortex

Fossella

Fan

Liu

et al. 2008

Biological Psychology

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“…Carriers of the at-risk allele (A1ϩ) of the TaqIA polymorphism show a negative relationship between weight gain and caudate response to milkshake when fasted, whereas noncarriers (A1Ϫ) do not (Stice et al, 2008a(Stice et al, , 2010b. The TaqIA polymorphism lies on the ANKK1 gene downstream of the dopamine receptor D2 (DRD2) gene (Fossella et al, 2006). A1ϩ individuals have reduced central DRD2 availability (Thompson et al, 1997;Pohjalainen et al, 1998) and an increased incidence of addictive behaviors such as substance use, overeating, and obesity (Comings et al, 1993;Noble et al, 1994;Blum et al, 1996;Jenkinson et al, 2000;Klein et al, 2007;Esposito-Smythers et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility

et al. 2015

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In rodents, food-predictive cues elicit eating in the absence of hunger (Weingarten, 1983). This behavior is disrupted by the disconnection of amygdala pathways to the lateral hypothalamus (Petrovich et al., 2002). Whether this circuit contributes to long-term weight gain is unknown. Using fMRI in 32 healthy individuals, we demonstrate here that the amygdala response to the taste of a milkshake when sated but not hungry positively predicts weight change. This effect is independent of sex, initial BMI, and total circulating ghrelin levels, but it is only present in individuals who do not carry a copy of the A1 allele of the Taq1A polymorphism. In contrast, A1 allele carriers, who have decreased D2 receptor density (Blum et al., 1996), show a positive association between caudate response and weight change. Regardless of genotype, however, dynamic causal modeling supports unidirectional gustatory input from basolateral amygdala (BLA) to hypothalamus in sated subjects. This finding suggests that, as in rodents, external cues gain access to the homeostatic control circuits of the human hypothalamus via the amygdala. In contrast, during hunger, gustatory inputs enter the hypothalamus and drive bidirectional connectivity with the amygdala. These findings implicate the BLA-hypothalamic circuit in long-term weight change related to nonhomeostatic eating and provide compelling evidence that distinct brain mechanisms confer susceptibility to weight gain depending upon individual differences in dopamine signaling.

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“…A recent functional magnetic resonance imaging (fMRI) study showed association with the DRD2/ANKK1 TaqIA polymorphism: A1 allele carriers showed different functional activation of the anterior cingulate gyrus while performing the attention network test (Fossella et al 2006).…”

mentioning

confidence: 99%

Genetic factors of reaction time performance: DRD4 7-repeat allele associated with slower responses

Székely

Balota

Duchek

et al. 2010

Genes, Brain and Behavior

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Twin studies indicate substantial inherited components in cognitive abilities. One of the most extensively studied candidate genes of cognitive functioning is the dopamine D4 receptor gene (DRD4), which has been suggested to be related to attentional disorders. Based on reaction time data of 245 Caucasians participating in different cognitive tasks, slower responses characterized the group with the 7-repeat allele. This effect was present in both sexes and was not because of fatigue. To our knowledge, this is the first report on significant association (P = 0.0001) between the DRD4 variable number of tandem repeat (VNTR) polymorphism and response latencies in a non-clinical adult sample. Other studied dopaminergic polymorphisms did not show an association with reaction time. These results illustrate that speed-of-performance measures derived from multiple reaction time tasks using standardization procedures could be promising tools to detect unique genetic effects in the background of cognitive abilities.

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Evaluation of a structural polymorphism in the ankyrin repeat and kinase domain containing 1 (ANKK1) gene and the activation of executive attention networks

Cited by 47 publications

References 36 publications

Provisional hypotheses for the molecular genetics of cognitive development: Imaging genetic pathways in the anterior cingulate cortex

Provisional hypotheses for the molecular genetics of cognitive development: Imaging genetic pathways in the anterior cingulate cortex

Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility

Genetic factors of reaction time performance: DRD4 7-repeat allele associated with slower responses

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