Evaluation of a suture electrode for direct bladder stimulation in a lower motor neuron lesioned animal model

Walter, James S.; Wheeler, John S.; Cai, Wuying; King, William; Wurster, Robert D.

doi:10.1109/86.769406

Cited by 33 publications

(42 citation statements)

References 21 publications

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“…In our prior of cats and dogs studies we observed higher bladder pressures to stimulation [14][15][16][17][18][19]. In our most recent study of dogs, we used similar but fewer bipolar barb electrodes on the bladder wall than were used in this study.…”

Section: Problem With the Animal Modelmentioning

confidence: 95%

“…There pulse duration is similar to the 400 s pulse duration used here. Our prior study using current-response tests demonstrated no improvement in the peak bladder pressure that was induced with pulse duration longer than 400 s [15,19]. , Magasi et al [12,13] did not state their stimulating frequency; based on their extensive review of the literature they may have been using a frequency in the range of the 40 Hz tested here.…”

Section: Problem With Stimulation Methodsmentioning

confidence: 99%

“…In a few initial tests, a lower current of 10 mA was tested first when there was a concern about possible leg muscle contractions. Other stimulation parameters were set to levels reported to induce maximal bladder pressures including 400 s pulses, 40 Hz stimulating frequency and 5 s stimulation periods [14,[16][17][18][19].…”

Section: Surgery and Bladder Wall Stimulationmentioning

confidence: 99%

“…We have been investigating optimal methods of bladder wall stimulation [14][15][16][17][18][19]. Recently we reported that bipolar barb electrodes with little separation between the two stimulating surfaces were effective for inducing high bladder pressures in anesthetized dogs [14].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Bipolar Permaloc™ Electrodes for Direct Bladder Stimulation

Walter¹,

Allen²,

Sayers³

et al. 2012

TOREHJ

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Abstract:Purpose: A bladder control system for spinal cord injured (SCI) patients is needed that can be implanted with minimally invasive methods. New Permaloc bipolar electrodes consisting of 6 mm helical, wire, stimulating surfaces separated by 3 mm and a polypropylene securing barb (Synapse Biomedical Inc) were developed for this application. They are implanted on the bladder wall with a 16 gauge needle, a minimally invasive method.Methods: Seven swines were anesthetized, the lower urinary tract exposed and instrumented with pressure transducers. Four Permaloc TM electrodes were implanted following identification of effective bladder wall stimulation sites next to the ureters and dorsal neurovascular bundle. Bladder stimulation to induce high pressures was conducted at 40 Hz, 400 s pulses, 5 s stimulation periods and a high stimulating current of 40 mA.Results: At the high stimulating current peak bladder pressures were low, ranging from 12±2 to15±3 cm H 2 0, insufficient to induce urination. Urethral sphincter contractions occurred during high bladder pressure. A spinal reflex role for high sphincter pressures during stimulation was shown by similar high pressures recorded during a bladder squeeze test without stimulation. Conclusions:Stimulation with Permaloc TM bipolar electrodes at high currents produced insufficient bladder pressures for urination. Further modifications of the electrode such as greater separation of the bipolar stimulating surfaces or changes in the testing methods such as alternative animal models are needed to induce high bladder pressures without side effects.

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Section: Problem With the Animal Modelmentioning

confidence: 95%

Section: Problem With Stimulation Methodsmentioning

confidence: 99%

Section: Surgery and Bladder Wall Stimulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Bipolar Permaloc™ Electrodes for Direct Bladder Stimulation

Walter¹,

Allen²,

Sayers³

et al. 2012

TOREHJ

View full text Add to dashboard Cite

show abstract

“…The implantable micro-stimulators are widely used in the treatment of the bladder leakage control [1], interrupt of pains, shaking syndromes of Parkinson's disease [2], muscle nerve stimulation [3], and cochlear implants [4]. Moreover, the stimulus frequency, current, and waveform of each application are different.…”

Section: Introductionmentioning

confidence: 99%

An Implantable SOC Chip for Micro-stimulating and Neural Signal Recording

Wang

Huang

Lee

et al. 2006

APCCAS 2006 - 2006 IEEE Asia Pacific Conference on Circuits and Systems

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Abstract-An implantable SOC chip for micro-stimulation and neural signal recording is presented. This work possesses a multi-parameter control protocol to provide different stimulation waveforms, for various pain treatments of muscles and stimulating applications. Additionally, the proposed SOC chip supports several transmission rates of RS232, which in turn provides a flexibility to be integrated in a variety of different applications. Moreover, an IA (instrument amplifier) with CMRR of 120 dB and the stopband attenuation of 38 dB/dec is employed, which is capable of sensing very low voltage (1 to 10 V) neural signal. The proposed design is implemented using TSMC 2P4M 0.35 m CMOS process.

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Ultracompliant Carbon Nanotube Direct Bladder Device

Yan

Bruns

et al. 2019

Adv Healthcare Materials

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The bladder, stomach, intestines, heart, and lungs all move dynamically to achieve their purpose. A long-term implantable device that can attach onto an organ, sense its movement, and deliver current to modify the organ function would be useful in many therapeutic applications. The bladder, for example, can suffer from incomplete contractions that result in urinary retention with patients requiring using catheterization. Those affected may benefit from a combination of strain sensor and electrical stimulator to better control bladder emptying. We describe the materials and design of such a device made from thin layer carbon nanotube (CNT) and Ecoflex 00-50 and demonstrate its function with in vivo feline bladders. During bench-top characterization, the resistive and capacitive sensors exhibited reliable output throughout 5,000 stretching cycles under physiology condition. In vivo measurement with piezoresistive device showed a high correlation between sensor resistance and volume. Stimulation driven from Pt-PDMS composite electrodes successfully induced bladder contraction. We This article is protected by copyright. All rights reserved. present method for reliable connection and packaging of medical grade wire to the CNT device. This work is an important step toward the translation of lowdurometer elastomers, stretchable CNT percolation and Pt-PDMS composite, which are ideal for large strain bioelectric applications to sense or modulate dynamic organ states.

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Evaluation of a suture electrode for direct bladder stimulation in a lower motor neuron lesioned animal model

Cited by 33 publications

References 21 publications

Evaluation of Bipolar Permaloc™ Electrodes for Direct Bladder Stimulation

Evaluation of Bipolar Permaloc™ Electrodes for Direct Bladder Stimulation

An Implantable SOC Chip for Micro-stimulating and Neural Signal Recording

Ultracompliant Carbon Nanotube Direct Bladder Device

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