Evaluation of a topical iron chelator in animals and in human beings: Short-term photoprotection by 2-furildioxime

Bissett, Donald; Oelrich, DM; Hannon, Daniel P.

doi:10.1016/s0190-9622(94)70218-7

Cited by 31 publications

(17 citation statements)

References 13 publications

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“…This was done with a Waldmann UV 800 (Waldmann Lichttechnik GmbH, Germany) equipped with a Philips TL/12 lamp emitting wavelengths in the 280-350 nm range (maximum 306 nm) [21]. The amount of UVB administered was assessed with a Waldmann UV meter (Waldmann Lichttechnik GmbH).…”

Section: Measurement Of Lipid Peroxidation and Erythema In Guinea Pigmentioning

confidence: 99%

Protective Effects of (–)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

Kim

Hwang

Cho

et al. 2001

Skin Pharmacol Physiol

117

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It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (–)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 ± 144 and 286 ± 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 ± 45 and 191 ± 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-ĸB and AP-1 binding activities were also inhibited by EGCG treatment.

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Section: Measurement Of Lipid Peroxidation and Erythema In Guinea Pigmentioning

confidence: 99%

Protective Effects of (–)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

Kim

Hwang

Cho

et al. 2001

Skin Pharmacol Physiol

117

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“…Iron chelator 2-furildioxime (FDO) applied topically can prevent UV-induced erythema, sunburn cell formation, epidermal thickening, infiltration of inflammatory cells, and induction of epidermal ornithine decarboxylase. 214 However, FDO does not have high SPF. Topical FDO is significantly more potent when combined with other UV filters, with the SPF increases from 4 (FDO alone) to over 30 (FDO plus SPF 4 sunscreen).…”

Section: Other Photoprotective Agentsmentioning

confidence: 99%

Photoprotection

Kullavanijaya

Lim

2005

Journal of the American Academy of Dermatology

345

265

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“…Later, Bissett and McBride showed the efficacy of a topical iron chelator, 2‐furildioxime (FDO) 71 . FDO exerted inhibitory effects on UV‐induced erythema and epidermal hypertrophy in human skin 72 …”

Section: Applications Of Iron Ion Chelatorsmentioning

confidence: 99%

Iron chelators may help prevent photoaging

Kitazawa

Iwasaki

Sakamoto

2006

J of Cosmetic Dermatology

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For years, cosmetic ingredients for anti-aging treatments have attracted consumers. Skin aging is accelerated by reactive oxygen species (ROS), generated by exposure to solar ultraviolet radiation (UVR), in a process known as photoaging. Because cutaneous iron catalyses ROS generation, it is thought to play a key role in photoaging. Iron is essential to almost all forms of life. However, excess iron is potentially toxic as its catalytic activity induces the generation of ROS. Iron-catalysed ROS generation is involved in numerous pathological conditions, including cutaneous damage. When skin is directly exposed to UVR, cutaneous intracellular catalytic iron levels increase because of the release of iron from iron-binding proteins such as ferritin. Consequently, the subsequent ROS generation may overwhelm cutaneous defense systems such as the cellular iron sequestration and ROS scavenging capacity. The harmful role of excess cutaneous iron implies that there may be a potential for topical iron chelator treatments. We now consider cutaneous photodamage skin photoaging as the result of iron-catalysed ROS generation and discuss preventative strategies based on iron chelators.

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Evaluation of a topical iron chelator in animals and in human beings: Short-term photoprotection by 2-furildioxime

Cited by 31 publications

References 13 publications

Protective Effects of (–)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

Protective Effects of (–)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

Photoprotection

Iron chelators may help prevent photoaging

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