Evaluation of ABO blood group in subjects with CVD risk factors in a population sample from northeastern Iran

Yaghooti‐Khorasani, Mahdiyeh; Ghazizadeh, Hamideh; Bijari, Moniba; Mohammadi‐Bajgiran, Maryam; Oladi, Mohammad Reza; Zare-Feizabadi, Reza; Timar, Ameneh; Nazarpour, Shahin; Khedmatgozar, Hamed; Rohban, Mohadeseh; Hasanzadeh, Elahe; Javandoost, Ali; Banpoor, Hamed; Andalibi, Mohammad Sobhan Sheikh; Moazedi, Sara; Mosalmanzadeh, Negin; Aghasizadeh, Malihe; Ferns, Gordon A.; Esmaily, Habibollah; Ghayour‐Mobarhan, Majid

doi:10.1016/j.dsx.2020.08.031

Cited by 2 publications

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are also predictable factors for successful aging and a healthy life. 10 Besides these traditional risk factors, a positive family history acts as a crucial risk factor in the pathogenicity of CAD. This gives rise to premature coronary artery diseases in offspring and acts as a major predictor of CAD, not only because of the inherited susceptibility genes but also because of the shared lifestyles, which include diet and sedentary routine that may exaggerate the predisposition to cardiac events.…”

Section: Introductionmentioning

confidence: 99%

Unraveling Coronary Artery Disease vulnerability in patients with ABO gene polymorphism: A Case-Control Study in Pakistan perspective

Saad,

Ahmed,

Khatoon

et al. 2023

Pak Heart J

View full text Add to dashboard Cite

Objectives: This study was aimed to explore the association of ABO gene variants with coronary artery disease. Methodology: This was a case-control study. Cases and controls were individuals with greater than 50% and less than 30% stenosis, respectively. One hundred thirty-eight samples were obtained, with 69 cases and 69 controls. The operator completed a proforma regarding demographics, medical history, and blood group. The bench work included blood typing, followed by blood genotyping by DNA extraction, PCR, and then Sanger's sequencing. The single nucleotide polymorphisms (SNPs) selected for the ABO gene were rs8176746 and rs8176719. Results: The results show that 68.1% of the participants were male cases, compared to 49.27% controls. The frequency of patients belonging to the old age group (60-75 years) was 65.21% in cases and 34.78% in controls. A+ was the most prevalent group in cases, with 33.33%, followed by 24.6% B+, 23.2% O+, and 4.3% AB+. Patients with Rh-ve groups were rare. On the contrary, 33.33% of patients were O+ in controls. A chi-square test showed that the A+ blood group was significantly associated with CAD, having a p-value of 0.01. Although blood genotypes did not show a significant p-value, the odds of having genotype AA was 1.35 times higher in cases compared to the controls. Conclusion: This study shows that the A+ group is significantly associated with CAD. The data obtained through Sanger’s sequencing determined the genetic variants of blood groups, but no statistically significant association was found between them and CAD.

show abstract

Section: Introductionmentioning

confidence: 99%