Evaluation of ABO blood groups in oral potentially malignant disorders and oral squamous cell carcinoma-a retrospective study in South Indian population

Poornima, R; Shyam, Ndvn; Grover, Kiran; Vaishali, N.; Preethi, P.; Shobhita, K. C.

doi:10.5958/2347-6206.2018.00010.9

Cited by 2 publications

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“…Association of blood Group A in various cancers, including gastric cancers, breast cancers, pancreatic cancers, skin cancers, ovary and oesophageal cancers has been reported in various cohort studies and systematic reviews (Vasan et al, 2016;Mao et al, 2019;Miao et al, 2014;Celic et al, 2019;Huang et al, 2015). The association between ABO blood type with oral cancer and other potentially malignant disorders has also been studied but has yet not been established as risk factors due to contradictory findings (Gupta et al, 2020;Mortazavi et al, 2014;Jaleel and Nagarajappa, 2012;Jalili et al, 2018;Jamil et al, 2006;Kumari et al, 2017;Oroei, 2019;Poornima et al, 2018;Shishodia et al, 2018;Singh et al, 2014;Bhateja et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have been conducted to assess ABO blood group and its association with oral cancer, other potentially malignant disorders, and oral submucous fibrosis (Gupta et al, 2020;Mortazavi et al, 2014;Jaleel and Nagarajappa, 2012;Jalili et al, 2018;Jamil et al, 2006;Kumari et al, 2017;Oroei, 2019;Poornima et al, 2018;Shishodia et al, 2018;Singh et al, 2014;Bhateja et al, 2014). However, evidence from these studies remains inconclusive.…”

Section: Introductionmentioning

confidence: 99%

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ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis– A Systematic Review and Meta-Analysis

Singh

Purohit

2021

Asian Pac J Cancer Prev

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Objective: The study aimed to evaluate the association between ABO blood groups and oral cancer, other potentially malignant disorders (OPMD), and oral submucous fibrosis (OSMF). Materials and methods: A search was conducted in Medline, Cochrane databases, Google Scholar, Scopus, Web of Science and Directory of Open Access Journals (DOAJ) for studies evaluating ABO blood groups as risk factors for oral cancer and OPMD among cases and controls. The PRISMA guidelines were followed for the meta-analysis. Participants included patients with oral cancer, and OPMD diagnosed using histopathologic investigations. Sub-group analysis was conducted to evaluate the association between blood groups and OSMF. Quality was evaluated using the Risk of Bias Assessment tool. Fixed effects model was used to assess the odds ratio for the association. Results: There were 1,352, 414, and 299 cases of oral cancer, OPMD, and OSMF and 11,699, 7,382 and 7,307 controls for analysis respectively. Blood group A was significantly associated with both oral cancer (Odds ratio: 1.27 [95% CI, 1.10, 1.47], P= 0.001) and OPMD (Odds ratio: 1.33 [95% CI, 1.01, 1.47], P= 0.04). No association was noted between blood group B and AB with oral cancer, OPMD, and OSMF. Blood group O was significantly associated with lower chances of oral cancer (Odds ratio: 0.81 [95% CI, 0.71, 0.93], P= 0.002). Conclusion: Meta-analysis suggests blood group A has a greater risk for developing oral cancer and OPMD. Blood group O was associated with lower chances of oral cancer. No association was noted between ABO blood group system with OSMF.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis– A Systematic Review and Meta-Analysis

Singh

Purohit

2021

Asian Pac J Cancer Prev

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Investigating the expression patterns of Androgen Receptor in different grades of Oral Squamous Cell carcinoma

Khan,

Amin,

Baqai

et al. 2024

Preprint

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Oral squamous cell carcinoma (OSCC) is a common malignant tumor, in the head and neck region with a high incidence and prevalence rate globally. Oral cancer is one of the most deadly and common cancers among men in Asian nations including Bangladesh, India, and Pakistan. Certain viral infections, alcohol, betel quid, areca nut, and tobacco use have all been linked to the development of OSCC. Although the role of hormones and their receptors have been explored in many types of cancers, in OSCC it is still poorly explored. Previous studies have reported that sex hormone androgens and androgen receptors (AR) are involved in growth and progression of breast and prostate cancers. However their role in OSCC remains controversial. The study aims to understand the expression patterns of the androgen receptor at the transcriptional and translational levels in various grades of patients with OSCC. Further to that the expression of AR changes in response to testosterone was also compared in OSCC parients in relation to healthy population. After obtaining consent, the participants were divided into four categories: healthy, poorly differentiated (PD), moderately differentiated (MD), and well differentiated (WD) squamous cell carcinoma (SCC). By creating an appropriate questionnaire, the patient's history was acquired. Samples of blood and tissue were obtained and processed, for testosterone level measurement using ELISA and RNA and protein estimation using commercially available kits, respectively. Tissue samples were visualized using H&E staining. We found that PDSCC group has highest expression levels of AR mRNA, followed by MDSCC and WDSCC. AR expression and serum testosterone levels were found to have moderately significant association in all subjects, determined by Spearman’s correlation. All groups showed full length AR expression while the splice variant AR-V7 was detected exclusively in MDSCC and PDSCC. This is suggestive of AR-V7 role in in OSCC progression. Higher levels of serum testosterone in OSCC patients than in healthy people provide an evidence for the carcinogenic potential of AR in OSCC.

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Evaluation of ABO blood groups in oral potentially malignant disorders and oral squamous cell carcinoma-a retrospective study in South Indian population

Cited by 2 publications

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ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis– A Systematic Review and Meta-Analysis

ABO Blood Groups and Its Association with Oral Cancer, Oral Potentially Malignant Disorders and Oral Submucous Fibrosis– A Systematic Review and Meta-Analysis

Investigating the expression patterns of Androgen Receptor in different grades of Oral Squamous Cell carcinoma

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