Evaluation of abortifacient efficacy of Rumex steudelli (Tult) root traditionally used medicinal plant in South West Ethiopia

Feroche, Alemu Tadesse

doi:10.31254/phyto.2015.4406

Cited by 4 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Successful mating was verified by the presence of spermatozoa in the vaginal smear of the female. The presence of spermatozoa in the vaginal smear marked the first day of gestation [23][24][25].…”

Section: Gestation Lengthmentioning

confidence: 99%

"Effects of the Ethanolic Extract of Avocado (Persea americana M.) Seed Powder on Growth Characteristics and Reproductive Performance of Female Cavies (Cavia porcelus L.)"

Baulland

2023

BJSTR

View full text Add to dashboard Cite

show abstract

Section: Gestation Lengthmentioning

confidence: 99%

"Effects of the Ethanolic Extract of Avocado (Persea americana M.) Seed Powder on Growth Characteristics and Reproductive Performance of Female Cavies (Cavia porcelus L.)"

Baulland

2023

BJSTR

View full text Add to dashboard Cite

show abstract

“…The foregoing are indicators that abortion in Nigeria is a public health concern as it affects both the young and the old both directly and indirectly, thus a social challenge. Herbal medicines are also emmenagogues (to avoid uterine flow) and oxytocic's (to stimulate uterine tightening, predominantly to induce labor) [12]. The use of herbal medicine has been on the increase in many developing countries [13].…”

Section: Introductionmentioning

confidence: 99%

The uterotonic screening of calyx extracts of Hibiscus sabdariffa on estrogenized isolated Uterus of Wister strain albino rats

Olugbenga¹,

Anuoluwapo²,

Bitrus³

et al. 2022

Int. J. Front. Biol. Pharm. Res.

View full text Add to dashboard Cite

The claim of the use of orally consumed concentrated Hibiscus sabdariffa calyx preparation for the purpose of abortion in view of its widely uses as a beverage in the present period of economic hardship where it is a preferred beverage due to its affordability, naturalness and for its numerous medicinal properties has posed another element of concern to the female folks. This study was aimed to screen extracts of H. sabdariffa calyx of its acclaimed uterotonic activity. Contractile responses of estrogenized isolated rat uterus using various volumes (0.1, 0.2, 0.4, 0.6, 0.8, 1.0,1.6 ml) were established with oxytocin (1x10-4 g/ml), ergometrine (1x10-4 g/ml), misoprostol (1x10-4 g/ml), Acetylcholine (1x10-3 g/ml) and five different extracts of H. sabdariffa - ethanol (2.0x10-3 g/ml), methanol (2.0x10-3 g/ml), acetone (2.0x10-3 g/ml), cold water (2.0x10-3 g/ml) and hot water (2.0x10-3 g/ml). After these, nifedipine, acetylcholine and salbutamol were used to challenge the maximal responses of the isolated uterine tissue to oxytocin, acetylcholine and the cold aqueous extract of H. sabdariffa (CWEHs). The CWEHs was equally potent at inducing contraction activity compared to the standard drugs. This study further shows reduction in the amplitude of contraction produced by CWEHs in the presence of Promethazine (1×10−6 g/ml) and Nifedipine (1×10−6 g/ml). The blockade is more pronounced in promethazine compared to Nifedipine. Aqueous extract of Hibiscus sabdariffa calyx possess uterotonic activity on estrogenized isolated rat uterine muscle with mechanism of action related to histamine receptors and contraction of the myometrial cells as the was antagonized by promethazine and Nifedipine. This could be a justification for its alarming use as an abortifacient.

show abstract

The potential effect of the Rumex vesicarius water seeds extract treatment on mice before and during pregnancy on the serum enzymes and the histology of kidney and liver

et al. 2022

View full text Add to dashboard Cite

Rumex vesicarius (R. vesicarius or RV) is an annual plant having rounded leaves, with flowers containing seeds. RV protects liver, resists cancer, and removes free radicals in cells. The aim of this study was to illustrate the effect of the R. vesicarius water seeds extract (RVWSE) treatment on mice before and during pregnancy, and its action on the liver and kidney histology and enzymes, aspartate aminotransferase and alanine aminotransferase, the blood urea nitrogen, the creatinine, and the uric acid. The seeds of R. vesicarius were collected, extracted, and its component analyzed via Gas chromatography mass spectrometry. Mice treated with 10 mg kg−1 RVWSE via feeding tube for 1 week before mating, or during pregnancy. The number of offspring or litter size was recorded and the blood sample was collected at the end of the experiment to test the kidney and liver enzymes, and their histology. Results showed that RVWSE contains different phytochemicals consisting of some hexane and chloroform compounds. The fertility rate of 1st treated pre-pregnancy group is 30% and the 2nd group is 35%. The offspring rate of 1st treated group showed higher new born rate (8 new born/female) than 2nd treated group (5.4 new born/female). The blood enzyme levels of the kidney and liver showed some variation between the two groups and their histology illustrates some non-significant variation between the treated and control groups of mice. The implications of the results of this study illustrate the safe use of the RVWSE, its effectiveness in improving mice fertility, and positive impact on biomarker of serum enzymes of liver and kidney with their histopathology.

show abstract

Evaluation of abortifacient efficacy of Rumex steudelli (Tult) root traditionally used medicinal plant in South West Ethiopia

Cited by 4 publications

References 5 publications

"Effects of the Ethanolic Extract of Avocado (Persea americana M.) Seed Powder on Growth Characteristics and Reproductive Performance of Female Cavies (Cavia porcelus L.)"

"Effects of the Ethanolic Extract of Avocado (Persea americana M.) Seed Powder on Growth Characteristics and Reproductive Performance of Female Cavies (Cavia porcelus L.)"

The uterotonic screening of calyx extracts of Hibiscus sabdariffa on estrogenized isolated Uterus of Wister strain albino rats

The potential effect of the Rumex vesicarius water seeds extract treatment on mice before and during pregnancy on the serum enzymes and the histology of kidney and liver

Contact Info

Product

Resources

About