Evaluation of accelerated collagen cross‐linking for the treatment of melting keratitis in ten cats

Famose, Frank

doi:10.1111/vop.12112

Cited by 36 publications

(60 citation statements)

References 65 publications

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“…Signs of melting were absent the day after initiated treatment in both groups. The ability of CXL to stop melting processes in the cornea is consistent with results from previous clinical studies in humans, dogs, and cats . A few clinical reports describe the use of CXL in animals as adjunct to medical therapy for melting keratitis.…”

Section: Discussionsupporting

confidence: 85%

“…CXL increases the bio‐mechanical strength and stabilizes the cornea by forming new cross‐links in the corneal stroma between collagen fibers and between proteoglycan core proteins, thus making it more resistant to melting and bacterial attack through steric hindrance . Hence, it has been used to treat corneal melting in humans, cats, dogs, and horses …”

Section: Introductionmentioning

confidence: 99%

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Corneal cross‐linking (CXL)—A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses

Edman

Ström

Ekesten

2019

Veterinary Ophthalmology

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Objective Compare CXL treatment with medical treatment alone in horses with stromal, ulcerative keratitis. Animals studied: 24 horses (24 eyes) with stromal, ulcerative keratitis were included. Procedure 12 horses were initially treated with CXL, and 12 horses were given conventional medical treatment. Topical medical treatment was added to horses in the CXL group if necessary. Parameters including cytology, microbial growth, time to fluorescein negativity, and time to inhibition of stromal melting were evaluated. Results After the first day of treatments, a decrease in inflammatory signs and pain from the eye was observed in both groups. Stromal melting ceased within 24 hours regardless of treatment. CXL treatment alone was sufficient in 3 horses with noninfectious, superficial stromal ulcerations. Clinical signs of impaired wound healing were seen after 3‐14 days in corneas with suspected or proven bacterial infection treated with CXL only, most likely because of insufficient elimination of bacteria deeper in the corneal stroma or because of re‐infection from bacteria in the conjunctiva. The average decrease in stromal ulcer area per day after onset of treatment was almost identical between the groups, and no significant difference in time to fluorescein negativity was found. Conclusions We consider CXL a possible useful adjunct treatment of corneal stromal ulcers in horses, especially for melting ulcers and as a potential alternative to prophylactic antibiotic treatment for noninfected stromal ulcers. However, CXL should not be used alone for infected or suspected infected stromal ulcers, because topical antibiotics were required in all horses with proven infectious keratitis.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Corneal cross‐linking (CXL)—A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses

Edman

Ström

Ekesten

2019

Veterinary Ophthalmology

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“…The KXL™ System (Avedro, Waltham, Mass., USA) is able to produce a light intensity of 30 mW/cm 2 , enabling ultrafast accelerated CXL with less than 3 min of UVA exposure. It appeared to be effective in a small group of KCN patients when combined with an LASEK procedure [57], and also for treatment of infectious keratitis in cats [58]. …”

Section: Evolution Of Riboflavin: Uva Corneal Collagen Crosslinkingmentioning

confidence: 99%

Corneal Collagen Crosslinking: A Systematic Review

Sorkin

Varssano²

2014

Ophthalmologica

166

122

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Keratoconus (KCN) is an ectatic disorder with progressive corneal thinning and a clinical picture of corneal protrusion, progressive irregular astigmatism, corneal fibrosis and visual deterioration. Other ectatic corneal disorders include: post-LASIK ectasia (PLE) and pellucid marginal degeneration (PMD). Corneal crosslinking (CXL) is a procedure whereby riboflavin sensitization with ultraviolet A radiation induces stromal crosslinks. This alters corneal biomechanics, causing an increase in corneal stiffness. In recent years, CXL has been an established treatment for the arrest of KCN, PLE and PMD progression. CXL has also been shown to be effective in the treatment of corneal infections, chemical burns, bullous keratopathy and other forms of corneal edema. This is a current review of CXL - its biomechanical principles, the evolution of CXL protocols in the past, present and future, indications for treatment, treatment efficacy and safety.

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“…The adverse and cytotoxic effects of high UV-A irradiation has been well documented on skin epithelium or keratinocytes 31. Though there have been studies on the effect of ACXL on animal eyes, there have been none on human LECs 11 32 33. There are, however, some studies that have found transient changes while evaluating the effect of ACXL on the corneal endothelium 34…”

Section: Discussionmentioning

confidence: 99%

Safety profile of accelerated corneal cross-linking versus conventional cross-linking: a comparative study on ex vivo-cultured limbal epithelial cells

et al. 2014

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Evaluation of accelerated collagen cross‐linking for the treatment of melting keratitis in ten cats

Abstract: Accelerated CXL appears to be a valuable option for the treatment of melting keratitis in cats. All the cases have reached a satisfactory outcome despite the individual differences in the conditions prior to the CXL treatment and the variable presence of infectious agents.

Cited by 36 publications

References 65 publications

Corneal cross‐linking (CXL)—A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses

Corneal cross‐linking (CXL)—A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses

Corneal Collagen Crosslinking: A Systematic Review

Safety profile of accelerated corneal cross-linking versus conventional cross-linking: a comparative study on ex vivo-cultured limbal epithelial cells

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