Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

Vargas-Calla, Ana; Gómez-Puerta, Luis A.; Calcina, Juan; Gonzales-Viera, Omar; Gavidia, C César; López-Urbina, María T.; Garcı́a, Héctor H.; González, Armando E.

doi:10.1016/j.apjtm.2015.12.005

Cited by 8 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experimental porcine cysticercosis has been developed using different protocols, mainly by oral inoculation of eggs or by ingestion of gravid proglottids of T. solium (de Aluja et al, 1996; Gonzalez et al, 2005; Kaur et al, 1995). Of these methods, the use of gravid proglottids produces a high parasitic load of cysticerci in pigs, likely as in natural pig infections (Boa et al, 2002; Gonzalez et al, 2005; Rodriguez-Hidalgo et al, 2003; Vargas-Calla et al, 2016). Our result using beetles as mechanical vectors produced a low parasitic load of cysticerci in pigs, like oral inoculation of eggs method (de Aluja et al, 1996; Fan et al, 1994; Kaur et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Experimental porcine cysticercosis using infected beetles with Taenia solium eggs

2018

Self Cite

View full text Add to dashboard Cite

Beetles are intermediate hosts for human and animal parasites, and several beetle species have been shown to carry Taenia eggs. An experimental porcine cysticercosis infection model was developed using beetles (Ammophorus rubripes) infected with Taenia solium eggs and then using these beetles for oral pig challenge. A total of 18 three months-old Landrace pigs were divided in four groups. Pigs from groups 1, 2, and 3 (n = 6 pigs per group) were challenged with one, three, and six beetles infected with T. solium eggs, containing approximately 52, 156 or 312 eggs respectively. Pigs were necropsied 12 weeks after infection to assess the presence of T. solium metacestode. Porcine cysticercosis by T. solium was produced in 17 out of 18 pigs (94.4%) challenged with infected beetles, all infected pigs had viable cysts. Only one pig from group 1 was negative to the presence of cysts. The median number of metacestodes per pig in groups 1, 2, and 3 were 2 (range 0-71), 26 (range 5-33) and 40 cysts (range 4-111), respectively. Experimental porcine cysticercosis infection is consistently obtained using beetles as mechanical vectors for T. solium eggs.

show abstract

Section: Discussionmentioning

confidence: 99%

Experimental porcine cysticercosis using infected beetles with Taenia solium eggs

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the other hand, in areas endemic for Taenia (T.) solium infection and possible unrecognized cerebral cysticercosis, the activity of praziquantel against T. solium metacestodes and the consequent immune response could possibly cause cerebral edema and epilectic attacks which is not expected for triclabendazole which is apparently not active on cysticerca [70,71] . Furthermore, TCZ is not only active against small liver flukes but also against the large liver fluke Fasciola hepatica [68,21,44,72] .…”

Section: Discussionmentioning

confidence: 99%

Current status of the treatment of paragonimiasis

Richter¹

2022

One Health Implement Res

View full text Add to dashboard Cite

Paragonimiasis, a foodborne trematodiasis is caused by various Paragonimus species endemic in Asia, Africa, and the Americas. Human infection occurs through consuming improperly cooked freshwater crustaceans, crabs or crayfish, eating raw meat of paratenic hosts or by ingesting metacercariae from contaminated hands and cooking utensils. More than 292 million persons worldwide are at risk. The morbidity associated with paragonimiasis includes acute febrile illness and chronic pleuro-pulmonary manifestations which may be confounded with tuberculosis or lung cancer. Ectopic manifestations mostly involve the central nervous system, heart, or subcutaneous tissues. Objectives: to evaluate the efficacy and safety of currently available drugs praziquantel (PZQ) and triclabendazole (TCZ). Methods: a PubMed and Google Scholar search and reference selection was performed according to the the Preferred Reporting Items for Systematic Reviews protocol using a combination of the terms “paragonimiasis” AND “treatment” OR “therap*” from 01/2000 to 02/2022. Results: no randomized controlled trials were identified. Five open trials on 487 patients treated with PZQ showed 81%-100% parasite clearance depending on dosage and duration. Three open trials on 226 patients with TCZ showed a 99.6% efficacy. A quantitative comparison was not applicable to retrospective analyses of hospital records, case series and case reports because of surgical interventions, various co-morbidities and -medications and definitions of cure. Some patients treated with PZQ required multiple courses or re-treatment with TCZ, whereas one patient treated with TCZ required re-treatment with PZQ. Conclusions: PZQ and TCZ are usually effective for treating paragonimiasis. Controlled randomized trials are required to compare the safety, efficacy and applicability of PZQ versus TCZ and to evaluate combined PZQ-TCZ therapy.

show abstract

“…Ninety two pig serum samples were provided by The Cysticercosis Working Group (CWGP) repository, but only 85 serum pig samples had complete necropsy and LLGP-EITB data: 48 positive samples were obtained from experimentally and naturally infected pigs that were LLGP-EITB positive; and 37 negative samples were obtained from pigs from industrialized farms from a non-endemic area that were LLGP-EITB negative (Vargas-Calla et al, 2016). Lor the infected pigs, the necropsy report included details about the total number of cysts and viable cysts found in the carcasses.…”

Section: Antigenicity Of Recombinant Tsolcl Using Sera From Infected mentioning

confidence: 99%

“…Lor the infected pigs, the necropsy report included details about the total number of cysts and viable cysts found in the carcasses. As the serum samples used in this study were provided by the CWGP, the infection of the pigs, LLGP-EITB of sera and necropsy protocols are described in more details in previous publications (Gomez-Puerta et al, 2018;Moreno et al, 2012;Vargas-Calla et al, 2016).…”

Section: Antigenicity Of Recombinant Tsolcl Using Sera From Infected mentioning

confidence: 99%

Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis

León-Janampa

Liendo

Gilman

et al. 2019

Veterinary Parasitology

View full text Add to dashboard Cite

Porcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, identification and characterization of potential new antigens for immunodiagnostic purposes is desired. The cysteine protease family has previously been found to have important immunodiagnostic properties. These proteases are expressed as zymogens which contain a signal peptide, pro-peptide, and an active domain. Subsequent catalytic cleavage of the pro-peptide converts these zymogens into enzymes. With the use of bioinformatic tools we *

show abstract

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

Abstract: TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

Cited by 8 publications

References 18 publications

Experimental porcine cysticercosis using infected beetles with Taenia solium eggs

Experimental porcine cysticercosis using infected beetles with Taenia solium eggs

Current status of the treatment of paragonimiasis

Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis

Contact Info

Product

Resources

About