Evaluation of Actual Maternal Serum Alpha-Fetoprotein (MSAFP) Levels in Placental Abruption and Associations with Adverse Outcomes

Erol, Seyit Ahmet; Altınboğa, Orhan; Yakıştıran, Betül; Öztürk, Filiz Halıcı; Başer, Emre; Çağlar, Ali Turhan

doi:10.1007/s42399-021-00794-7

Cited by 2 publications

(1 citation statement)

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“…The etiology of vaginal bleeding has not been fully elucidated, but one of the most important causes is the separation of decidual vessels on the maternal-fetal face (9). It is well known that vaginal bleeding in early pregnancy affects the serum alpha-fetoprotein value (10,11), but its effect on other parameters is controversial. Some studies argue that early pregnancy bleeding affects serum PAPP-A and f β-hCG values (12,13), while some studies argue that there is no significant effect (14,15).…”

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confidence: 99%

Erken Gebelikte Vajinal Kanamanın İlk Trimester Tarama Testi, Uterin Arter Doppler İndeksleri ve Perinatal Sonuçlara Etkisi

et al. 2023

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Introduction We aimed to prospectively investigate the effect of first trimester vaginal bleeding on first trimester screening test, uterine artery (UtA) Doppler results and perinatal outcomes. Materials And Methods Fifty cases that presented with vaginal bleeding in the first trimester between 2019 and 2020 constituted the early vaginal bleeding (abortus imminens-threatened abortion) group and fifty cases without a history of vaginal bleeding in pregnancy constituted the control group. Demographic datas were noted at the first visit. Both groups were followed up until birth. First trimester screening test (double screening test) between 11-14 weeks and UtA Doppler examination between 20-24 weeks of gestation was performed. Perinatal outcomes and values of nuchal translucency (NT), free β human chorionic gonadotropin (f β-hCG), pregnancy-associated plasma protein A (PAPP-A), and UtA Doppler were compared between the two groups. Results There was no statistically significant difference was found between the two groups in terms of NT and PAPP-A among the first trimester screening test results (p=0.741 and p=0.937, respectively). In the group with threatened miscarriage, f β-hCG value was numerically higher, but there was no statistically significant difference (1.24±0.59 vs. 1.1±0.93, p=0.057). In the Doppler examination of the uterine artery, there was no statistically significant difference between the groups in terms of systolic/diastolic ratio, pulsatility index, resistive index and the presence of a notch. (p=0.713, p=0.528, p=424, p=0.538, respectively). Perinatal complication rate was statistically significantly higher in the study group (p = 0.013; Odds Ratio: 3.2, 95% CI 1.2 - 8.3). Conclusion Contrary to some different studies, we believe that first trimester screening test parameters or uterine artery Doppler flow indices do not have a place in predicting perinatal outcomes of pregnant women with a history of vaginal bleeding in the first trimester. In addition, early vaginal bleeding does not significantly affect screening parameters. Perinatal complication rate was found to be statistically significantly higher in the group with a history of threatened miscarriage.

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