Evaluation of acute and sublethal effects of chloroquine (C18H26CIN3) on certain enzymological and histopathological biomarker responses of a freshwater fish Cyprinus carpio

Ramesh, Mathan; Anitha, S.; Poopal, Rama Krishnan; Shobana, Chellappan

doi:10.1016/j.toxrep.2017.11.006

Cited by 94 publications

(61 citation statements)

References 60 publications

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“…Recently many scientific communities have deviated towards the toxicity research on pharmaceuticals (Fabbri, 2015). We have already reported the impacts of few pharmaceuticals on fresh water edible fishes (Ambili et al., 2013; Saravanan et al., 2014; Ramesh et al., 2018a,b; Renuka et al., 2018). Fish farmers use unapproved chemicals to maintain the health status of fishes by preventing and treating disease outbreaks (Nyambok and Kastner, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Due to their extensive usage and occurrence in the aquatic environment these compounds are now recognized as emerging pollutants. Even a low level of antibiotics in the water bodies could enhance microbial resistance, which results in adverse health problems to humans (Liu et al., 2018; Ramesh et al., 2018a). Amoxicillin, an aminopenicillin derivative, is a prophylactic drug belonging to β-lactams drug groups that are habitually prescribed medication against microbial infections.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

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Labeo rohita were exposed to amoxicillin at a concentration of 1 mg/L (Treatment -I) and 0.5 mg/L (Treatment-II) for a period of 35 days. Numerous alterations were found in amoxicillin treatment groups when compared to the control group. Hemoglobin (Hb), hematocrit (Hct), and erythrocytes (RBCs) levels were significantly ( P < 0.05) decreased. Leukocytes (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were significantly ( P < 0.05) increased. In the plasma and gill tissues, ionic compounds (sodium, potassium, and chloride) levels were significantly declined throughout the treatment period. The plasma biochemical profiles were significantly altered: glucose level remained low (except at the end of 7 th day in Treatment -I) till 35 days of the treatment period. Biphasic trend occurred in the protein level, significant increase was observed on 7 th and 28 th day (Treatment -I and -II), and 35 th day (Treatment -I), and in remaining days its level was found to be decreased. Glutamate oxaloacetate transaminase (GOT) activity in the plasma was inhibited significantly, whereas in the gill, liver, and kidney tissues the enzyme activity was elevated. Plasma glutamate pyruvate transaminase (GPT) activity was inhibited throughout the study period. GPT activity in the gill was found to be elevated during the treatment period. Liver GPT activity was elevated in all the treatments except 28 th (Treatment-I) and 35 th day (Treatment-I, and II). GPT activity in the kidney was elevated (except 14 th day in Treatment-II). Lactate dehydrogenase (LDH) activity was inhibited in plasma (except 14 th day in Treatment-II), gill, liver (except 7 th day in Treatment-I), and kidney tissues significantly ( P < 0.05). The present study emphasizes that amoxicillin at 1 and 0.5 mg/L concentrations affects the hematological/biochemical/electrolytes/enzymological parameters of fish and these biomarkers serve as an effective test system for environmental risk assessment of pharmaceuticals in the aquatic environment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

Self Cite

View full text Add to dashboard Cite

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“…Similarly, Olaitan et al (2017) found CQ in wastewater effluents in Nigeria (Olaitan et al, 2017). The general findings (Table 2) confirmed that CQ and HCQ compounds could be risky for the environment and should be classified as harmful to aquatic organisms (Ramesh et al, 2018;Zurita et al, 2005).…”

Section: Potential Environmental Impact Of Administered Drugsmentioning

confidence: 70%

Current emerging SARS-CoV-2 pandemic: Potential direct/indirect negative impacts of virus persistence and related therapeutic drugs on the aquatic compartments

Race

Ferraro

Galdiero

et al. 2020

Environmental Research

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The purpose of the present work is to provide a complete overview of possible direct/indirect implications on the quality of aquatic compartments due to the recent SARS-CoV-2 outbreak. With this aim, the environmental impacts are mainly related to i) the virus persistence in sewage and wastewaters, and ii) possible fate in aquatic compartments of drugs tested and administered to SARS-CoV-2 infected patients. Because SARS-CoV-2 spread is very recent, and there is a lack of specific studies on this strain, the virus persistence in wastewaters, the parameters influencing the persistence, as well as the detection methodologies are referenced to the general coronaviruses group. However, the present detailed report of up-to-date knowledge on this topic can provide a useful source for further studies focusing on more deepened investigations of SARS-CoV-2 behaviour in the environment. Such a perspective is significant not only for the control of virus diffusion but also represents a crucial point for the identification of produced alteration to the environmental quality.

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“…Hydroxychloroquine and chloroquine are some of the drugs that have been used to treat COVID-19 ( Liu et al, 2020a ). These drugs have been described as persistent, bioaccumulative, and dangerous to aquatic organisms ( Ramesh et al, 2018 ), and they are considered emerging pollutants ( Daughton, 2014 ; Zurita et al, 2005 ). This is highly relevant since it is known that wastewater treatment systems do not have adequate processes for treatment these drugs, which will enter into freshwater ecosystems ( Ashfaq et al, 2017 ).…”

Section: Indirect Impact Of Covid-19 On the Environmentmentioning

confidence: 99%

Environment and COVID-19: Pollutants, impacts, dissemination, management and recommendations for facing future epidemic threats

Espejo

Celis

Chiang

et al. 2020

Science of The Total Environment

157

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Coronavirus disease 2019 (COVID-19) has become a global pandemic. Its relationship with environmental factors is an issue that has attracted the attention of scientists and governments. This article aims to deal with a possible association between COVID-19 and environmental factors and provide some recommendations for adequately controlling future epidemic threats. Environmental management through ecosystem services has a relevant role in exposing and spreading infectious diseases, reduction of pollutants, and control of climatic factors. Pollutants and viruses (such as COVID-19) produce negative immunological responses and share similar mechanisms of action. Therefore, they can have an additive and enhancing role in viral diseases. Significant associations between air pollution and COVID-19 have been reported. Particulate matter (PM2.5, PM10) can obstruct the airway, exacerbating cases of COVID-19. Some climatic factors have been shown to affect SARS-CoV-2 transmission. Yet, it is not well established if climatic factors might have a cause-effect relationship to the spreading of SARS-CoV-2. So far, positive as well as negative indirect environmental impacts have been reported, with negative impacts greater and more persistent. Too little is known about the current pandemic to evaluate whether there is an association between environment and positive COVID-19 cases. We recommend smart technology to collect data remotely, the implementation of “one health” approach between public health physicians and veterinarians, and the use of biodegradable medical supplies in future epidemic threats.

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Evaluation of acute and sublethal effects of chloroquine (C18H26CIN3) on certain enzymological and histopathological biomarker responses of a freshwater fish Cyprinus carpio

Abstract: Graphical abstract

Cited by 94 publications

References 60 publications

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Current emerging SARS-CoV-2 pandemic: Potential direct/indirect negative impacts of virus persistence and related therapeutic drugs on the aquatic compartments

Environment and COVID-19: Pollutants, impacts, dissemination, management and recommendations for facing future epidemic threats

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