Evaluation of acute oral toxicity, cytotoxicity, antidepressant and antioxidant activities of Japanese mint (Mentha arvensis L.) oil

Yousuf, Tanjina; Akter, Rasheda; Ahmed, Jamiuddin; Mazumdar, Santosh; Talukder, D.; Nandi, Nemai Chandra; Nurulamin, Mohammad

doi:10.1016/j.phyplu.2021.100140

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…In this study, the authors associated the inhibition mainly with the presence of terpenes in the extracts of spearmint [ 27 ]. Furthermore, our three commercial extracts exhibited a higher reducing capacity measured by FRAP than Yousuf et al [ 28 ]. The high capacity to trap free radicals is likely since these mint species’ metabolites with antioxidant characteristics have a high hydrogen donating capacity [ 27 ].…”

Section: Discussionmentioning

confidence: 44%

Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

Henao-Rojas

Osorio

Isaza³

et al. 2022

Molecules

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Spearmint (Mentha spicata L.) has been widely studied for its diversity of compounds for product generation. However, studies describing the chemical and biological characteristics of commercial spearmint materials from different origins are scarce. For this reason, this research aimed to bioprospecting spearmint from three origins: Colombia (Col), Mexico (Mex), and Egypt (Eg). We performed a biological activity analysis, such as FRAP, DPPH, and ABTS, inhibition potential of S. pyogenes, K. pneumoniae, E. coli, P. aeuroginosa, S. aureus, S aureus Methicillin-Resistant, and E. faecalis. Furthermore, we performed chemical assays, such as total polyphenol and rosmarinic acid, and untargeted metabolomics via HPLC-MS/MS. Finally, we developed a causality analysis to integrate biological activities with chemical analyses. We found significant differences between the samples for the total polyphenol and rosmarinic acid contents, FRAP, and inhibition analyses for Methicillin-Resistant S. aureus and E. faecalis. Also, clear metabolic differentiation was observed among the three commercial materials evaluated. These results allow us to propose data-driven uses for the three spearmint materials available in current markets.

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Section: Discussionmentioning

confidence: 44%

Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

Henao-Rojas

Osorio

Isaza³

et al. 2022

Molecules

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“…Hasil penelitian (Naidu et al, 2014), menunjukkan ekstrak metanol 80% daun mint (Mentha spicata) menghasilkan nilai LC 50 sebesar 1701 ppm dan dikategorikan tidak toksik terhadap larva udang. Selain itu, minyak atsiri Mentha arvensis menghasilkan nilai LC 50 139,73 ppm (toksik) (Yousuf et al, 2021).…”

Section: Pendahuluanunclassified

“…Prosedur penelitian ini dilakukan sesuai dengan metode penelitian (Yousuf et al, 2021;Granatum et al, 2018) dengan beberapa modifikasi.…”

Section: Metode Penelitianunclassified

“…Hasil penelitian ini berbeda dengan penelitian sebelumnya, dimana ekstrak metanol 80% daun mint (Mentha spicata) pada konsentrasi 100-0,07 µg/ml menghasilkan nilai LC 50 sebesar 1701 ppm dan dikategorikan tidak toksik terhadap larva udang (Naidu et al, 2014), minyak atsiri Mentha arvensis menghasilkan nilai LC 50 139,73 ppm (toksik) (Yousuf et al, 2021) dan pada ekstrak etanol 95% daun mint (Mentha arvensis) dengan konsentrasi 75 µg/ml, 100 µg/ml, 125 µg/ml, 250 µg/ml, 250 µg/ml dan 1000 µg/ml didapatkan nilai LC 50 sebesar 100 µg/ml (100 ppm) (da Costa et al, 2009). Sedangkan pada penelitian ini yaitu ekstrak etanol 96% daun mint (Mentha arvensis) pada konsentrasi 1 ppm, 2 ppm, 3 ppm, 4 ppm dan 5 ppm didapatkan nilai LC 50 sebesar 3,5223 ppm dan dikategorikan sangat toksik.…”

Section: Hasil Dan Pembahasanunclassified

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Toksisitas Daun Mint (Mentha arvensis) Terhadap Larva Udang (Artemia salina Leach)

Retno¹,

Surahmaida²

2022

INSOLOGI: Jurnal Sains dan Teknologi

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Medicinal plant are part of the flora that grows and is widespread in Indonesia, one of which is mint (Mentha arvensis). Mint plant is an aromatic herbaceous plant that is widely used for air freshener, as a food garnish, and medicine. However, few studies have tested the toxicity of mint leaves. To achieve safe treatment, many studies have been carried out in pharmacological and toxicity testing of medicinal plants. The toxicity test of these medicinal plants uses the Brine Shrimp Lethality Test (BSLT) method after 24 hours of exposure to the sample being tested. This study aimed to determine the toxicity of mint leaves (Mentha arvensis) to shrimp larvae (Artemia salina Leach). Mint leaf extract was obtained from a 24-hour maceration extraction process using 96% ethanol as a solvent. Toxicity test were carried out using the Brine Shrimp Lethality Test (BSLT) method with a concentration of 1 ppm, 2 ppm, 3 ppm, 4 ppm ad 5 ppm. The percentage of deaths of shrimp larvae was calculated and calculation of LC50 value using Probit analysis. The LC50 value was obtained 3,5223 ppm and its categorized as very toxic to shrimp larvae because LC50 < 30 ppm. It can be concluded that mint leaves (Mentha arvensis) can be used as a candidate to be developed as an anti-cancer drug.

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“…Mentha species are used to treat gastrointestinal and respiratory diseases and are also employed as carminative, anti-spasmodic and sedative agents [1,6,7]. Indeed, in a recent article, Yousuf et al [8] reported an antidepressant effect of the essential oil from M. arvensis. Similarly, the anesthetic potential of M. piperita was demonstrated by Brandão et al [9].…”

Section: Introductionmentioning

confidence: 99%

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Zengin

Ceylan

et al. 2022

Plants

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Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M. spicata extracts, obtained by the use of four solvents (hexane, chloroform, acetone and acetone/water) were chemically characterized using HPLC-ESI-MS n, which allowed for identification of 27 phenolic compounds. The extracts’ antioxidant and enzyme inhibitory properties were investigated. In addition, neuroprotective effects were evaluated in hypothalamic HypoE22 cells, and the ability of the extracts to prevent the hydrogen peroxide-induced degradation of dopamine and serotonin was observed. The best antioxidant effect was achieved for all the extraction methods using acetone/water as a solvent. These extracts were the richest in acacetin, eriodictyol, hesperidin, sagerinic acid, naringenin, luteolin, chlorogenic acid, chrysoeriol and apigenin. The intrinsic antioxidant and enzyme inhibition properties of the acetone/water extract could also explain, albeit partially, its efficacy in preventing prostaglandin E2 overproduction and dopamine depletion (82.9% turnover reduction) in HypoE22 cells exposed to hydrogen peroxide. Thus, our observations can provide a scientific confirmation of the neuromodulatory and neuroprotective effects of M. spicata.

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Evaluation of acute oral toxicity, cytotoxicity, antidepressant and antioxidant activities of Japanese mint (Mentha arvensis L.) oil

Cited by 9 publications

References 34 publications

Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

Toksisitas Daun Mint (Mentha arvensis) Terhadap Larva Udang (Artemia salina Leach)

Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

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