Evaluation of acute-phase proteins and inflammatory mediators changes in native chickens experimentally infected with Salmonella typhimurium

Yazdani, Ahmad; Asasi, Keramat; Nazifi, Saeed

doi:10.1007/s00580-014-1972-0

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…It is well documented that the concentration of sialic acid immediately rises following different inflammatory stimuli. [52][53][54] In the present study, the concentrations of total sialic acid, lipid-bound sialic acid, and proteinbound sialic acid were significantly higher in the LPSchallenged groups than in the negative control group. The administration of meloxicam did not significantly affect LBSA level but reduced PBSA in comparison with the positive control group.…”

Section: Indicated Thatmentioning

confidence: 44%

Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

Tavakoli¹,

Abdi-Hachesoo²,

Nazifi³

et al. 2020

JIR

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Purpose: Dexamethasone has been widely used to treat acute inflammatory diseases and endotoxic shocks in animal models. Meloxicam is one of the most commonly used antiinflammatory agents in avian species. However, little is known about the effects of dexamethasone and meloxicam on lipopolysaccharide (LPS)-induced acute inflammatory response in birds. In the present study, LPS-challenged broiler chickens were used to investigate the comparative protective effects of meloxicam and dexamethasone on LPSinduced acute inflammatory responses. Methods: Lipopolysaccharide (LPS)-induced acute lung injury (ALI) histopathological scores, selected serum acute phase reactants, inflammatory mediators, and gangliosides were evaluated in broiler chickens inoculated with E. coli LPS and simultaneously treated with two doses of meloxicam (0.5 and 2 mg/kg BW) and dexamethasone (2 and 4 mg/kg BW). Results: LPS-induced ALI scores were not significantly different between the meloxicamtreated, dexamethasone-treated, and untreated positive control groups at 4 hours after LPS inoculation. Interleukin-6 concentrations were also statistically the same among the positive control, dexamethasone-treated, and meloxicam-treated groups at 3 and 12 hours after LPS inoculation. However, these anti-inflammatory drugs reduced adenosine deaminase, ceruloplasmin, lipid-bound sialic acid, protein-bound sialic acid, and total sialic acid in LPS-inoculated broiler chickens at 12, 24, and 48 hours after LPS inoculation in a drug-and dose-dependent manner. Ovotransferrin concentrations were not significantly different between positive control and treatment groups at 12 hours after LPS inoculation. However, twenty-four hours after LPS inoculation, all the treated groups, except the one treated with 0.5 mg/kg meloxicam, showed significantly lower concentrations of ovotransferrin as compared with the positive control group. Conclusion: Our results showed that dexamethasone was more effective than meloxicam in inhibiting the LPS-induced response in broiler chickens by diminishing the serum levels of adenosine deaminase, ceruloplasmin, and gangliosides.

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Section: Indicated Thatmentioning

confidence: 44%

Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by Escherichia coli Lipopolysaccharide in Broiler Chickens

Tavakoli¹,

Abdi-Hachesoo²,

Nazifi³

et al. 2020

JIR

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“…LPL are lipid emulsifiers and aids in lipid digestibility ( Zhang et al, 2022 ); and gangliosides are glycosphingolipids, being important components of eukaryotic cell membranes, and are often receptors for Salmonella spp. ( Yazdani et al, 2015 ). Besides these metabolites were also shown to act as sites of adherence of S. Enteritidis in cells of chicken oviductal mucosa ( Li et al, 2003 ).…”

Section: Resultsmentioning

confidence: 99%

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Hoepers,

Nunes,

Almeida-Souza

et al. 2024

Poultry Science

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“…In the current study, increased SAA levels were only observed in room 2 at 7 dpi for some birds inoculated with D2008b in the presence or absence of G2008b, corresponding to liver-contaminated groups in this room. According to some authors, SAA concentrations in broiler chicken sera increase during the acute phase infection after exposure to a stimulus, such as vaccination [ 51 ] or Escherichia coli [ 52 ] and Salmonella Typhimurium infections [ 53 ]. However, its concentrations rapidly drop due to its short half-life, which could explain why very few significant differences were observed in this work.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Colonization of Campylobacter jejuni and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens

et al. 2023

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Campylobacter jejuni is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between C. jejuni and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of C. jejuni, cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. Campylobacter appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although Campylobacter is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity.

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Evaluation of acute-phase proteins and inflammatory mediators changes in native chickens experimentally infected with Salmonella typhimurium

Cited by 5 publications

References 41 publications

<p>Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by <em>Escherichia coli</em> Lipopolysaccharide in Broiler Chickens</p>

<p>Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced by <em>Escherichia coli</em> Lipopolysaccharide in Broiler Chickens</p>

Harnessing probiotics capability to combat Salmonella Heidelberg and improve intestinal health in broilers

Intestinal Colonization of Campylobacter jejuni and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens

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