Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study

Tahir, Takdir; Febrianti, Nur; Wahyuni, Sri; Rabia,; Syam, Yuliana

doi:10.1016/j.mcpsp.2020.100091

Cited by 9 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On Day 3, we found that wound healing was characterized by the formation of granulation tissue replacing the provisional matrix of blood clots (Tahir et al, 2017). We found fibroblasts originating from stem cells in skin progeria lamina had migrated and promoted the production of cytokines and growth factors secreted by platelets and macrophages during injury, especially TGF-β and FGF (Tahir et al, 2020). FGF secretion from macrophages and fibroblasts increased on Treatment Days 7–14 (Kajdaniuk et al, 2013).…”

Section: Discussionmentioning

confidence: 95%

“…RDFE increases TGF-β 1 levels and the formation of tissue fibroblasts (Tahir et al, 2020). We found a strong positive correlation between the duration of treatment (i.e., between Treatment Days 3 and 14) and TGF-β 1 levels ( r = .872).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies using a similar active polyphenolic in the same content as dragon fruit showed the substance was effective at wound healing in allosane-induced mice (Yan et al, 2013). Other similar studies have assessed the effect of using dragon fruit extract as a topical cream on tissue granulation, collagen, and hexosamine growth to accelerate wound healing (Tahir et al, 2020).…”

Section: Wound Diametermentioning

confidence: 99%

See 2 more Smart Citations

Topical Cream Derived From Hylocereus polyrhizus (Red Dragon Fruit) Extract Accelerates Wound Healing Through Increased Hydroxyproline and Fibroblast Growth Factor 2 Levels: A Pilot Study

Tahir,

Djamaluddin,

Thalib

et al. 2023

Plastic and Aesthetic Nursing

View full text Add to dashboard Cite

The red dragon fruit (Hylocereus polyrhizus) extract (RDFE) is frequently used for a variety of therapeutic purposes (e.g., boosting the immune system, promoting a healthy gastrointestinal system, improving wound healing). We investigated the effects of a topical cream containing 7.5% RDFE on hydroxyproline and fibroblast growth factor 2 (FGF-2) levels and wound healing. On Day 0, we divided a total of 36 albino male Wistar rats into two equal groups. Using an 8-mm punch biopsy, we created a circular excision to fascial depth on the back of each rat. On Day 1, we treated the control group (n = 18) with 20 mg of base cream and the RDFE group (n = 18) with 20 mg of 7.5% RDFE cream. We measured hydroxyproline and FGF-2 levels in the wound tissue using an ELISA method on Days 3, 7, and 14. We found that on Day 3, hydroxyproline levels were significantly lower in the treatment group than in the control group (p = .031). We also found a significant correlation between FGF-2 levels in the treatment group and wound diameter (p = .02). On the basis of the results of this study, we concluded that using a topical cream containing 7.5% RDFE has the potential to accelerate wound healing by increasing levels of hydroxyproline and FGF-2 in the wound.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Wound Diametermentioning

confidence: 99%

See 1 more Smart Citation

Topical Cream Derived From Hylocereus polyrhizus (Red Dragon Fruit) Extract Accelerates Wound Healing Through Increased Hydroxyproline and Fibroblast Growth Factor 2 Levels: A Pilot Study

Tahir,

Djamaluddin,

Thalib

et al. 2023

Plastic and Aesthetic Nursing

View full text Add to dashboard Cite

show abstract

“…Skin wound management, especially for wounds with diminished healing ability caused by extreme external injuries or chronic illnesses, represents a central concern in clinical care and remains a notable problem in public health ( 1 , 2 ). According to a recent global survey by the World Health Organization, acute or chronic wound problems plague over 305 million people worldwide ( 3 ). Chronic wound management results in long-term physical and mental suffering because of the protracted treatment courses and a rapidly growing global economic burden.…”

Section: Introductionmentioning

confidence: 99%

A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing

Yao

Yin

et al. 2022

Sci. Adv.

View full text Add to dashboard Cite

Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature–activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optimally designed electromechanical synergistic stimulation could regulate the wound microenvironment to accelerate healing metabolism, promote wound closure, and inhibit infection. This work provided an effective wound healing strategy in the context of a programmable temperature-responsive, battery-free electromechanical synergistic biomedical device.

show abstract

“…A statistical survey by the World Health Organization shows that there are 305 million people are suffering from acute and chronic wounds. [ 1 ] Thus, wound care is still a big challenge worldwide.…”

Section: Introductionmentioning

confidence: 99%

Waterproof and Breathable Wound Dressing Composited By Expanded Polytetrafluoroethylene Backing and Hydrogel

Zheng

Chen

Zou

et al. 2022

Macromolecular Bioscience

View full text Add to dashboard Cite

Wound dressings with waterproof, breathable, and bacterial‐resistant properties are still rarely realized. In this work, a newly hydrogel‐based dressing is designed with a backing of expanded polytetrafluoroethylene (ePTFE) film. The ePTFE grafting with polyvinylpyrrolidone (PVP) brush is composited with hydrogel successfully with an adhesion energy of ≈80 kJ m−2. In this resultant composite, the ePTFE backing contributes excellent breathability, water resistance, and bacterial barrier property. The water vapor transmission rate of the composite is 4.83 × 103 g m−2 × 24 h, which can maintain the moist environment of wound and relieve pain by evaporating water. Notably, it can withstand 500 mm water column for over 300 s, which is obviously better than the commonly used nonwoven fabric backing materials. It can also prevent the invasion of bacteria, because the pores of ePTFE backing are smaller than those of most common bacterial. As a result, the composite with an ePTFE film backing has a positive effect in accelerating wound healing, promoting the reconstruction of intact epidermis and reducing inflammation.

show abstract

Evaluation of acute wound healing potential of red dragon fruit (Hylocereus Polyrhizus) extract cream on type III collagen and Epidermal Growth Factor (EGF) levels: An animal study

Cited by 9 publications

References 11 publications

Topical Cream Derived From Hylocereus polyrhizus (Red Dragon Fruit) Extract Accelerates Wound Healing Through Increased Hydroxyproline and Fibroblast Growth Factor 2 Levels: A Pilot Study

Topical Cream Derived From Hylocereus polyrhizus (Red Dragon Fruit) Extract Accelerates Wound Healing Through Increased Hydroxyproline and Fibroblast Growth Factor 2 Levels: A Pilot Study

A programmable and skin temperature–activated electromechanical synergistic dressing for effective wound healing

Waterproof and Breathable Wound Dressing Composited By Expanded Polytetrafluoroethylene Backing and Hydrogel

Contact Info

Product

Resources

About