Evaluation of Adding Lidocaine to Dexamethasone in the Intra-tympanic Injection for Management of Tinnitus: A Prospective, Randomized, Controlled Double-blinded Trial

Elzayat, Saad; Ragab, Sameh M.; Eisa, Magdy; Amer, Mohamed; Mandour, Mahmoud; Mehraz, Mai

doi:10.5935/0946-5448.20180009

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Savastano [30] Prospective clinical trial Significant improvement in level of disturbance and tinnitus loudness was observed O'Brien et al [31] Pilot, prospective efficacy trial Significant improvement on the tinnitus functional index scores in participants Elzayat et al [32] Prospective, randomized, controlled double-blinded study The effectiveness rates were 74.5% in the intratympanic lidocaine+dexamethasone group, and 50.0%, 50.5%, and 40.0% in dexamethasone alone group 은행잎 추출제…”

Section: Study Study Design Resultsmentioning

confidence: 99%

Pharmacologic treatment of tinnitus

Lee¹

2022

J Korean Med Assoc

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Background: Tinnitus is one of the most frequent symptoms seen in otology practice. The pathogenesis of tinnitus has not yet been clearly explained, and no single hypothesis or theory is sufficient to explain the mechanisms involved in the development of this condition. Tinnitus is most commonly treated using pharmacologic methods. The aim of this study is to summarize the drugs used for the treatment of tinnitus based on previous research.Current Concepts: Pharmacologic treatment of tinnitus depends on various mechanisms. Hyperactivity of the central auditory system, neurotransmitter imbalances in auditory pathways, and blood circulation may be involved. Symptoms such as anxiety, stress, sleep disturbance, and depression are also associated with tinnitus. Various medications have been used, including anxiolytics, anticonvulsants, antidepressants, N-methyl-D-aspartate antagonists, local anesthetics, ginkgo biloba extract, other pharmacologic agents, and nutritional supplements.Discussion and Conclusion: Although pharmacologic treatments are frequently used in primary care, no medication is specifically indicated for tinnitus. Further studies are required to understand the mechanisms of tinnitus to ensure treatment safety. Appropriate medication may improve tinnitus, but efficacy is dependent upon patient comorbidities. To increase the success rate of pharmacologic treatment for tinnitus, both detailed history taking and physical examination are essential.

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Section: Study Study Design Resultsmentioning

confidence: 99%

Pharmacologic treatment of tinnitus

Lee¹

2022

J Korean Med Assoc

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“…Over six months, these forty-four patients were assessed for tinnitus, and at the end of six months period, a significant and appreciable relief in tinnitus was found in patients treated with the combination of Dexame-thasone and Lidocaine as compared to dexamethasone alone. 19…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Ayub

Ahmed

Afzal

et al. 2022

PAFMJ

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Objective: To determine the effectiveness of Intratympanic Dexamethasone with Lidocaine in control of idiopathic tinnitus. Study Design: Randomized control trial (Clinical Trials. gov Identifier: NCT04798391). Place and Duration of Study: ENT Department, PAF Hospital, Sargodha Pakistan, from Apr 2017 to Jul 2019. Methodology: 264 consenting patients with idiopathic unilateral tinnitus presenting at ENT Department PAF Hospital Sargodha were assessed for tinnitus severity using the modified tinnitus handicap inventory. The scores were recorded and subsequently administered intra-tympanicaly 2.0ml (milli-liter) of Dexamethasone and Lidocaine (1.5 ml Dexamethasone ± 0.5 ml 1% Lidocaine). The dose was repeated twice at weekly intervals. All the patients were reassessed on the modified tinnitus handicap inventory two weeks after the third Intra-tympanic administration, with patients divided into responsive and noresponsive groups depending on ten points or more improvement in tinnitus score. Results: Mean modified tinnitus handicap inventory score pre-therapy was 29.6 ± 5.68, and post-therapy was 17.1 ± 7.45. Independent-sample T-test applied showed a p-value of <0.001. Conclusion: Intratympanic Dexamethasone with lidocaine has a definitively positive outcome on tinnitus improvement.

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“…Pharmacologic agents applied in the treatment of hearing loss include glutamate inhibitors such as caroverine (Tinnex), derivatives of trimetazidine anti-ischemic agent such as trimetazidine dihydrochloride (Adexor), and lidocaine perfusion of the inner ear specifically for tinnitus. These treatments are not available in all countries and reports of effectiveness are controversial [ 56 , 57 , 58 ].…”

Section: Current Treatment Methodsmentioning

confidence: 99%

Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

et al. 2020

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Long-term noise exposure often results in noise induced hearing loss (NIHL). Tinnitus, the generation of phantom sounds, can also result from noise exposure, although understanding of its underlying mechanisms are limited. Recent studies, however, are shedding light on the neural processes involved in NIHL and tinnitus, leading to potential new and innovative treatments. This review focuses on the assessment of NIHL, available treatments, and development of new pharmacologic and non-pharmacologic treatments based on recent studies of central auditory plasticity and adaptive changes in hearing. We discuss the mechanisms and maladaptive plasticity of NIHL, neuronal aspects of tinnitus triggers, and mechanisms such as tinnitus-associated neural changes at the cochlear nucleus underlying the generation of tinnitus after noise-induced deafferentation. We include observations from recent studies, including our own studies on associated risks and emerging treatments for tinnitus. Increasing knowledge of neural plasticity and adaptive changes in the central auditory system suggest that NIHL is preventable and transient abnormalities may be reversable, although ongoing research in assessment and early detection of hearing difficulties is still urgently needed. Since no treatment can yet reverse noise-related damage completely, preventative strategies and increased awareness of hearing health are essential.

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Evaluation of Adding Lidocaine to Dexamethasone in the Intra-tympanic Injection for Management of Tinnitus: A Prospective, Randomized, Controlled Double-blinded Trial

Abstract: ITLD seems to be effective for SIT than ITD alone. The indication of ITLD for tinnitus needs to be limited to specific cases of resistant medical treatment.

Cited by 7 publications

References 10 publications

Pharmacologic treatment of tinnitus

Pharmacologic treatment of tinnitus

Effectiveness of Intratympanic Dexamethasone with Lidocaine for Alleviation of Tinnitus

Noise Induced Hearing Loss and Tinnitus—New Research Developments and Remaining Gaps in Disease Assessment, Treatment, and Prevention

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