Evaluation of Adiposity Phenotypes: Lipid Accumulation Product Index, Visceral Adipose Index and Body Roundness Index as Predictor Markers for Metabolic Syndrome Development in Type 2 Diabetes Mellitus

Asaad, Remal

doi:10.21608/bfsa.2022.271823

Bulletin of Pharmaceutical Sciences. Assiut

2022

DOI: 10.21608/bfsa.2022.271823

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Evaluation of Adiposity Phenotypes: Lipid Accumulation Product Index, Visceral Adipose Index and Body Roundness Index as Predictor Markers for Metabolic Syndrome Development in Type 2 Diabetes Mellitus

Remal Asaad

Abstract: Visceral obesity is strongly associated with Metabolic syndrome (MetS) and increases the risk of cardiovascular disease in type II diabetes mellitus (T2DM). We aimed in this study to determine the best discriminator of obesity indexes to predict the occurrence of MetS in T2DM patients. The present study was conducted on 129 T2DM patients (Mets+: 70.54% & MetS-: 29.45%) during the period from 2020 to 2021. MetS+ patients have higher HbA1C, TG, and obesity indexes (BMI, WC, BF%, BRI, VAI, LAP) compared with MetS… Show more

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Cited by 3 publications

References 12 publications

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Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population

Abdulaziz Asaad

2023

RJPT

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Notable incidence of obesity and dysfunction of adiposity tissue is strongly presented in type 2 diabetes mellitus (T2DM) worldwide. Relative Fat Mass (RFM) is anew, simple and inexpensive marker of whole body fat that predicts diabetes, dyslipidemia and dysglycemia as cardio-metabolic disorders. The current study aimed to evaluate the clinical applications of RFM as an obesity marker to predict the diabetes and to evaluate metabolic disorders associated with development of T2DM. The study was conducted on 118 adult patients with T2DMand on 51 healthy individuals seen at Tishreen University Hospital (TUH) and Diabetes Center of Lattakia city- Syria. Results confirm that RFM is higher in females than males with ratio of 1.5. Strong significant association of RFM withelevated levels of lipid profile-parameters, glycated-hemoglobin (HbA1c)> 8% and eGFR between 30-44ml/min/1.73m2 is seen as uncontrolled T2DM patients (P-value<0.05). RFM can predict diabetes with cutoff value of 33.60 (AUC: 0.77, sensitivity of 72% and Specificity of 100%) in comparison with healthy control, and with cutoff value of 40 with (AUC:0.92, sensitivity of 85% and Specificity of 93%) in females in comparison with males. In conclusion, this study has demonstrated that RFM is a whole body fat marker which significantly associated with obesity, gender and cardio-metabolic disorders in T2DM.

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Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population

Abdulaziz Asaad

2023

RJPT

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Statistical Overview of Drug Shortage in Syria

Antakly,

Najjar,

Abbood

2024

IJAPSR

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Access to medications is a fundamental aspect of healthcare and vital for human well-being. Medicine shortages are widespread and impact countries across all income levels. This research aimed to monitor the characteristics of drug shortages in Syria through a distributed survey. 76% of the sample were females. 88.9% of the sample were 20-29 years old. A high percentage of the participants were single (86.6%). 62% were students. Pharmacy is the profession or field of study for most participants (83.4%). Half of the participants live in the city (51%). Most participants work at a local pharmacy. The majority (79.5%) have fewer than 5 years of experience. Most participants were well-informed about medication shortages and personally experienced the impact of this issue in their professional or personal lives. A shortage of baby supplies, specifically baby milk, was reported by 70.33% of the surveyed parents. Tablets and capsules are the pharmaceutical formulations that experience shortages most commonly. Shortages were reported in all categories of medications. Participants identified the shortage of raw materials and low profit margins as significant factors contributing to drug shortages. Further research into drug shortages in Syria is warranted to address this issue.

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Insights into Therapeutic Peptides and their Quality Control

Abbood

2024

IJAPSR

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Therapeutic peptides have been garnering renewed attention in recent years. The manufacturing of peptides and protein-based drugs rapidly expands within the pharmaceutical sector. These compounds may be obtained through solid-phase synthesis or biotechnological methods. Peptides and proteins are delicate molecules that undergo chemical or physical changes such as oxidation of methionine, deamidation of asparagine and glutamine, isomerization, aggregation, and denaturation during production. The alterations could compromise the stability of the drugs, consequently impacting the therapeutic efficacy of the protein or peptide. It is essential to effectively monitor the quality of proteins or peptides to verify the preservation of their biological properties throughout the production process. This review outlines the official guidelines for quality control of peptides manufactured through solid-phase synthesis or genetic engineering. The discussion also covered the frequently utilized separation techniques for evaluating the efficacy of therapeutic peptides.

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Evaluation of Adiposity Phenotypes: Lipid Accumulation Product Index, Visceral Adipose Index and Body Roundness Index as Predictor Markers for Metabolic Syndrome Development in Type 2 Diabetes Mellitus

Cited by 3 publications

References 12 publications

Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population

Relative Fat Mass (RFM) Evaluates the Whole Body Fat (WBF) and predicts Cardio-metabolic Disorders as a new obesity marker in Syrian-population

Statistical Overview of Drug Shortage in Syria

Insights into Therapeutic Peptides and their Quality Control

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