Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography

Harada-Shoji, Narumi; Suzuki, Akihiko; Ishida, Toru; Zheng, Yangfan; Narikawa-Shiono, Yoko; Sato‐Tadano, Akiko; Ohta, Rie; Ohuchi, Noriaki

doi:10.1001/jamanetworkopen.2021.21505

Cited by 71 publications

(48 citation statements)

References 35 publications

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“…For women who started receiving screening mammography annually at age 40, the 10-year cumulative probability of a false positive recall is 61% in Taiwan [ 17 ]. In Japan, the neighboring country of Taiwan, a previous study noted that 59.3% of cases were categorized as having dense breast tissues where the sensitivity of mammography or ultrasonography alone did not exceed 80% [ 18 ]. On average, when a woman starts the annual screening between 40 to 49 years of age, she may encounter one false positive mammogram per 10 years, and one in four women will receive one false positive biopsy [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Prior Mammography Screening on the Performance of Breast Cancer Detection in Taiwan

Chang

Lien

et al. 2022

Healthcare

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The aim of this study was to investigate the influence of previous mammography screening on the performance of breast cancer detection. The screened women were divided into first-visit and follow-up groups for breast cancer screening. The positive predictive value (PPV), cancer detection rate (CDR), and recall rate were used to evaluate and analyze the overall screening performance among the two groups. Among them, 10,040 screenings (67.2%) were first visits and 4895 screenings (32.8%) were follow-up visits. The proportion of positive screening results for first-visit participants was higher than that for their follow-up counterparts (9.3% vs. 4.0%). A total of 98 participants (74 first-visit and 24 follow-up visit) were confirmed to have breast cancer. The PPV for positive mammography for women who underwent biopsy confirmation was 28.7% overall, reaching 35.8% for the follow-up visit group and 27.0% for the first-visit group. The CDR was 6.6 per 1000 overall, reaching 7.4 per 1000 for first-visit group and 4.9 per 1000 for the follow-up group. The overall recall rate was 7.9%, reaching 9.7% for the first-visit group and 4.2% for the follow-up group. The PPV is improved and the recall rate is decreased if prior mammography images are available for comparison when conducting mammography screening for breast cancer. By this study, we concluded that prior mammography plays an important role for breast cancer screening, while follow-up mammography may increase the diagnostic rate when compared to the prior mammography. We suggest that the public health authority can encourage subjects to undergo screenings in the same health institute where they regularly visit.

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Section: Introductionmentioning

confidence: 99%

The Effects of Prior Mammography Screening on the Performance of Breast Cancer Detection in Taiwan

Chang

Lien

et al. 2022

Healthcare

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“…Furthermore, the sensitivity was significantly higher when both MMG and US were used for women with dense breasts (77.5%) than when MMG alone was used (50%) [ 30 ]. The J-START, a large randomized controlled trial conducted in Japan to examine the usefulness of adding US to MMG examinations for women in their 40s with a high prevalence of dense breasts [ 31 , 32 ], demonstrated that the combined use of US and MMG increased the rate of breast cancer detection by 1.5-fold, as compared with the use of MMG alone. Furthermore, the combined use of US resulted in increased sensitivity, regardless of breast density, indicating that combined US is the best method for these women.…”

Section: Discussionmentioning

confidence: 99%

Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System

et al. 2021

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Dense breasts are a risk factor for breast cancer. Assessment of breast density is important and radiologist-dependent. We objectively measured mammographic density using the three-dimensional automatic mammographic density measurement device Volpara™ and examined the criteria for combined use of ultrasonography (US). Of 1227 patients who underwent primary breast cancer surgery between January 2019 and April 2021 at our hospital, 441 were included. A case series study was conducted based on patient age, diagnostic accuracy, effects of mammography (MMG) combined with US, size of invasion, and calcifications. The mean density of both breasts according to the Volpara Density Grade (VDG) was 0–3.4% in 2 patients, 3.5–7.4% in 55 patients, 7.5–15.4% in 173 patients, and ≥15.5% in 211 patients. Breast density tended to be higher in younger patients. Diagnostic accuracy of MMG tended to decrease with increasing breast density. US detection rates were not associated with VDG on MMG and were favorable at all densities. The risk of a non-detected result was high in patients without malignant suspicious calcifications. Supplementary use of US for patients without suspicious calcifications on MMG and high breast density, particularly ≥25.5%, could improve the breast cancer detection rate.

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“…Higher lesion stiffness corresponds to a greater probability of malignancy 72 . In clinical practice, US is used mainly for supplementary screening in women with dense breasts and negative mammogram findings, and for localizing lesions identified by mammography or MRI for puncture biopsy 73 , 74 .…”

Section: Imaging Techniques For Screening Breast Cancermentioning

confidence: 99%

Breast cancer screening and early diagnosis in Chinese women

Ding

Yang

et al. 2022

Cancer Biol Med

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Breast cancer is the most common malignant tumor in Chinese women, and its incidence is increasing. Regular screening is an effective method for early tumor detection and improving patient prognosis. In this review, we analyze the epidemiological changes and risk factors associated with breast cancer in China and describe the establishment of a screening strategy suitable for Chinese women. Chinese patients with breast cancer tend to be younger than Western patients and to have denser breasts. Therefore, the age of initial screening in Chinese women should be earlier, and the importance of screening with a combination of ultrasound and mammography is stressed. Moreover, Chinese patients with breast cancers have several ancestry-specific genetic features, and aiding in the determination of genetic screening strategies for identifying high-risk populations. On the basis of current studies, we summarize the development of risk-stratified breast cancer screening guidelines for Chinese women and describe the significant improvement in the prognosis of patients with breast cancer in China.

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Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography

Cited by 71 publications

References 35 publications

The Effects of Prior Mammography Screening on the Performance of Breast Cancer Detection in Taiwan

The Effects of Prior Mammography Screening on the Performance of Breast Cancer Detection in Taiwan

Optimal Breast Density Characterization Using a Three-Dimensional Automated Breast Densitometry System

Breast cancer screening and early diagnosis in Chinese women

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