Evaluation of Adsorbents for the Ta-178 Generator

Neirinckx, R.D.; Trumper, Jacob; LeBlanc, Arthur P.; Johnson, Philip C.

doi:10.1021/bk-1984-0241.ch010

ACS Symposium Series

1984

DOI: 10.1021/bk-1984-0241.ch010

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Evaluation of Adsorbents for the Ta-178 Generator

R.D. Neirinckx

Jacob Trumper

Arthur P. LeBlanc

et al.

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“…Manuscripts covered many advances in understanding the fundamental mechanisms that control stem and progenitor cell fate, and advances in working toward treating all tissues, from the lower extremities to the brain. Exciting basic and translational research was reported in using stem cells to treat osteoporosis [11], spinal cord injuries [12,13], radiation-induced fibrosis [14], glaucoma [15], globoid cell leukodystrophy [16], stroke [17], and Huntington's disease [18], to name just a few. It has truly been an exciting year, as we watch the stem cell field explode.…”

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Editorial: 2013—A Year of Clinical Success and Great Scientific Innovation in the Stem Cell Field

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Editorial: 2013—A Year of Clinical Success and Great Scientific Innovation in the Stem Cell Field

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The continuing important role of radionuclide generator systems for nuclear medicine

1994

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In this review, the continuing importance and status of development of radionuclide generator systems for nuclear medicine are discussed. Radioisotope costs and availability are two important factors, and both nuclear reactors and accelerator facilities are required for production of the parent radioisotopes. Radionuclide generator research is currently focused on the development of generators which provide radioisotopes for positron emission tomography (PET) applications and daughter radioisotopes for various therapeutic applications which decay primarily by particle emission. Generator research continues to be influenced by developments and requirements of complementary technologies, such as the increasing availability of PET. In addition, the availability of a wide spectrum of tumor-specific antibodies, fragments, and peptides for radioimmunodiagnosis and radioimmunotherapy has stimulated the need for generator-derived radioisotopes. The advantages of treatment of arthritis of the synovial joints with radioactive particles (radiation synovectomy) may be expected to be of increasing importance as the elderly population increases, and many of these agents are prepared using generator-derived radioisotopes such as yttrium-90 and rhenium-188. Therapeutic use of the "in vivo generator" is a new approach, where the less radiotoxic parent radioisotope is used to prepare tissue-specific therapeutic agents. Following in vivo site localization, decay of the parent provides the daughter for therapy at the target site. The principal foundation of most diagnostic agents will continue to require technetium-99m from the molybdenum-99/technetium-99m ("Moly") generator. With the limited availability of nuclear reactors and facilities necessary for production and processing of fission 99mTc and the significant issues and problems associated with radioactive waste processing, however, the possibility of utilizing lower specific activity 99Mo produced from neutron activation of enriched 98Mo may become practical in the future.

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Evaluation of Adsorbents for the Ta-178 Generator

Cited by 2 publications

References 0 publications

Editorial: 2013—A Year of Clinical Success and Great Scientific Innovation in the Stem Cell Field

Editorial: 2013—A Year of Clinical Success and Great Scientific Innovation in the Stem Cell Field

The continuing important role of radionuclide generator systems for nuclear medicine

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