Evaluation of Advanced Oxidation Protein Products (AOPP) and Superoxide Dismutase (SOD) Tissue Levels in Patients with Nasal Polyps

Zorlu, Mehmet Ekrem; Uygur, Kemal; Yilmaz, Niyazi Samet; Demirel, Özlem; Aydíl, Utku; Kızıl, Yusuf; Uslu, Sabri

doi:10.1007/s12070-022-03124-y

Cited by 1 publication

(2 citation statements)

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“…The level of AOPP from NP was higher than in the healthy control group. However, SOD activity was lower, indicating that oxidative stress plays a vital role in the development of nasal polyps [13]. Another mechanism of regulating oxidative stress is mediated by the thioredoxin-interacting protein (TXNIP), which acts as a pro-oxidant protein by suppressing the activity of thioredoxin (TRX) and its antioxidant function [14].…”

Section: Chronic Rhinosinusitis (Crs) and Nasal Polyps (Np)mentioning

confidence: 99%

“…One of the most critical lines of defense against ROS are enzymes crucial for the activity of antioxidant, such as SOD, catalase, glutathione peroxidase, and thiol reductase [13]. The expression and activity of SOD, which catalyzes the dismutation of superoxide anions, is lower in NP than in healthy mucosa, which is correlated with lower antioxidant blood levels in NP patients [34][35][36].…”

Section: Chronic Rhinosinusitis (Crs) and Nasal Polyps (Np)mentioning

confidence: 99%

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Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases

Sierra-Vargas

Montero-Vargas

Debray-García

et al. 2023

IJMS

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Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer. Even though the pathophysiological pathways that give rise to the development of distress and biological damage are not fully understood, scientific evidence indicates that redox-dependent signaling pathways are involved. This article presents an overview of the redox interaction of air pollution inside the human body and the courses related to chronic respiratory diseases.

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Section: Chronic Rhinosinusitis (Crs) and Nasal Polyps (Np)mentioning

confidence: 99%