Evaluation of aggressive surgical treatment for advanced carcinoma of the gallbladder

Ishikawa, Tadanori; Horimi, Tadashi; Shima, Yasuo; Okabayashi, Takehiro; Nishioka, Yasuhiko; Hamada, Masanori; Ichikawa, Junichi; Tsuji, Akinori; Takamatsu, Masahiro; Morita, Sojiro

doi:10.1007/s00534-003-0848-5

Cited by 43 publications

(56 citation statements)

References 13 publications

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“…However, effectiveness of radical re-resection for incidental gallbladder carcinomas at the T2 or more advanced stages has been reported [27]. The effectiveness of a radical surgical approach for gallbladder cancer has been the subject of a number of reports [42][43][44][45] from centers in Japan [46][47][48] and the United States. Therefore, there seems to be a need of more radical treatment of gallbladder carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry

2010

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Section: Discussionmentioning

confidence: 99%

Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry

2010

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“…The prognosis of patients resected with no distant metastasis (group A1) was significantly better than that of patients resected with distant metastases of the distant lymph nodes and the liver (group A2) (P= 0.0004). Also, there was no significant difference in the survival rate between the patients resected with distant metastasis (group A2) and chemotherapy cases (group B) [7].…”

Section: Discussionmentioning

confidence: 79%

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

Selvakumar

Zaidi

Pande

et al. 2015

Indian J Surg Oncol

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Although rare over most of the world, Gallbladder cancer is very common in northern india. A delayed presentation, aggressive nature,lack of randomised trials and a poor prognosis have all contributed to the nihilistic halo encircling gallbladder cancer. None of the advances in oncology have been exploited enough to shatter the nihilistic halo. In this background we sought to analyze if the addition of neoadjuvant chemotherapy had any impact on the resectability, overall and disease free survival in patients with advanced carcinoma of the gallbladder. We reviewed the records of all patients who underwent surgery for carcinoma of the gall bladder from 2004 to 2010 at our institute retrospectively. Twenty-one patients received neoadjuvant chemotherapy and subsequently taken up for surgery. Outcome analysis of these 21 patients were done by Kaplan meier method and graphs plotted. Out of the 21 patients who were taken up for surgery after neoadjuvant chemotherapy, fourteen patients underwent R0 resection (Group 1). Seven patients had been rendered inoperable on exploration (Group 2). Thus about 66.67 % of patients deemed resectable after neoadjuvant chemotherapy on imaging underwent R0 resection. The mean overall survival of the group 1 was 42.8 months versus 6.6 months of group 2(Hazard Ratio: 3.42). Neoadjuvant chemotherapy improves resectability in some patients with unresectable gall bladder cancer. Resection after neoadjuvant chemotherapy is feasible and may improve survival in a select group of patients. However randomized studies are required to establish its definitive role.

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“…1,2 Although hepatopancreatoduodenectomy has been performed for advanced stage disease as an attempt at curative resection over the past three decades, only a few sporadic case reports or small patient series have been published and the surgical outcomes of the procedure have not been adequately analyzed. [3][4][5][6][7][8][9][10] The purpose of the present study was to perform a systematic review of the literature to evaluate the safety and efficacy of hepatopancreatoduodenectomy for BC and GC.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers

Zhou

Zhang

et al. 2015

HPB

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Objectives: To review the evidence on the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers.Methods: Medline and EMBASE were systematically searched for papers of hepatopancreatoduodenectomy in patients with biliary and gallbladder cancers.Results: Eighteen studies involving 397 patients were reviewed. Major hepatectomy was undertaken in 81.3% of the 397 patients and the R0 resection rate was 71.3%. The morbidity and mortality rates were 78.9% and 10.3%, respectively. The 5-year overall survival rate ranged from 3% to 50% (median = 31%).The 5-year survival rate in patients who underwent curative resection was 18-68.8% (median = 51.3%), and 0% in patients who received non-curative resection.Conclusions: Hepatopancreatoduodenectomy is a challenging procedure with high morbidity and mortality rates. However, this procedure can provide a chance of long-term survival in patients in whom curative resection is feasible.

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Evaluation of aggressive surgical treatment for advanced carcinoma of the gallbladder

Abstract: These results indicated that radical surgery should be performed for patients with no distant metastasis, and that chemotherapy might be a useful alternative treatment for patients with distant metastasis in advanced carcinoma of the gallbladder.

Cited by 43 publications

References 13 publications

Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry

Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry

Resection After Neoadjuvant Chemotherapy in Advanced Carcinoma of the Gallbladder: a Retrospective Study

A systematic review of the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers

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