This study aims to identify the factors influencing the adoption of sustainable agribusiness practices in India and examines the most pertinent issues related to sustainable agri-supply chains and their management. The constructs of the study were identified through two sequential phases involving a review of literature and semi-structured interviews with supply chain enablers and intermediary (traders, government officials, local mandis or local markets) operating in Uttarakhand region, India. Data were collected from 1100 supply chain entities (including agri-farmers, partners and enablers across the supply chain) using semi-structured interviews. Twenty five items emerged as significantly influencing the adoption of sustainable agribusiness practices among farmers which have branched out of five factors. Further, it was found that low adoption capabilities and lack of uniform sustainable agribusiness policy were the major issues reported by the respondents. Identification of factors influencing adoption of sustainable agribusiness in Uttarakhand, India, can serve as a guiding tool for agribusiness regulators (government departments including Department of Rural Development), intermediaries (traders, NGOs, etc.). The examination of pertinent issues with the focus on major support required, bottlenecks in adoption, key benefits of sustainable agribusiness activities and most common sustainable practices is expected to provide a new understanding about the sustainable agribusiness-based issues in India.