Evaluation of albuminuria and its relationship with blood pressure in dogs with chronic kidney disease

Bacic, Ângela; Kogika, Márcia Mery; Barbaro, Kátia Cristina; Iuamoto, Cristina S.; Simões, Denise Maria Nunes; Santoro, Marcelo Larami

doi:10.1111/j.1939-165x.2009.00207.x

Cited by 40 publications

(60 citation statements)

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“…There are discrepancies in the literature regarding the percentage of dogs with kidney disease that develop systemic hypertension (MICHELL et al, 1997;JACOB et al, 2003;POLZIN, 2012). Such divergences may be due to different stages as well as to the nature of renal disease, because glomerulopathies are more likely to cause hypertension than tubulointerstitial diseases (CORTADELLAS et al, 2006;BACIC et al, 2010). There is only one previous study that evaluated the prevalence of hypertension in dogs with leishmaniosis, which revealed that 61.5% of the dogs with glomerular disease were hypertensive.…”

Section: Introductionmentioning

confidence: 89%

Hypertension and its correlation with renal lesions in dogs with leishmaniosis

Braga

Leite

Rosa

et al. 2015

Rev. Bras. Parasitol. Vet.

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To evaluate the prevalence of hypertension and its correlation with the severity of renal injury and proteinuria in dogs with leishmaniosis, sixty-six dogs were divided into two groups. Group 1 (G1) was composed of 54 dogs included in stage 1 of chronic kidney disease (CKD), and group 2 (G2) of twelve dogs in stages 2 and 3 of CKD. Prevalence of hypertension was 28.8%, comprising 22.2% of the dogs from G1 and 58.3% from G2 (P=0.011). The mean arterial blood pressure (BP) of dogs from G1 (135.7 ± 20.5) was lower than from G2 (170.0 ± 26.3) (P <0.001). Urine proteincreatinine ratio (UP/C) revealed values above 0.5 in 75.7% of the dogs, with 34% presenting hypertension. All dogs with hypertension had histopathological and laboratory evidence of glomerular disease. Although there was no statistically significant correlation between elevated BP and the severity of glomerular lesions (P=0.408), there was a statistically significant correlation between elevated BP and increased UP/C in the studied population (P=0.002). Thus, dogs with leishmaniosis and renal disease must be screened for the presence of hypertension so that treatment may be instituted as early as possible, in countries where treatment is allowed, to prevent the progression of renal damage.Keywords: Histopathology, kidney, Leishmania infantum chagasi, systolic blood pressure. ResumoPara avaliar a prevalência de hipertensão arterial e sua correlação com a severidade da lesão renal e proteinúria em cães com leishmaniose, 66 cães foram divididos em dois grupos. O grupo 1 (G1), composto por 54 cães em estágio 1 de doença renal crônica (DRC), e o grupo 2 (G2) por 12 cães em estágios 2 e 3 de DRC. A prevalência de hipertensão foi de 28,8%, compreendendo 22,2% dos cães de G1 e 58,3% dos cães de G2 (p = 0,011). A pressão arterial média (PA) de G1 (135,7 ± 20,5) foi inferior a de G2 (170,0 ± 26,3) (P <0,001). A relação proteína creatinina urinária (P/C U) foi maior que 0,5 em 75,7% dos cães, dos quais 34% possuíam hipertensão. Todos os cães com hipertensão apresentavam doença glomerular. Embora não tenha sido observada correlação estatisticamente significativa entre elevação da PA e severidade das lesões glomerulares (P =0,408), houve uma correlação significativa entre PA elevada e aumento da UP/C (P = 0,002). Portanto, cães com leishmaniose e doença renal devem ser pesquisados quanto à presença de hipertensão, para que o tratamento possa ser instituído o mais precocemente possível em países onde ele é permitido, para evitar a progressão da lesão renal.Palavras-chave: Histopatologia, rim, Leishmania infantum chagasi, pressão arterial sistólica.

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Section: Introductionmentioning

confidence: 89%

Hypertension and its correlation with renal lesions in dogs with leishmaniosis

Braga

Leite

Rosa

et al. 2015

Rev. Bras. Parasitol. Vet.

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“…Hypertension has been linked to target organ damage in dogs, and has been suggested to contribute to stroke2 and albuminuria5 in Greyhounds. High SP was associated with more severe proteinuria and renal histologic lesions in dogs with surgically induced renal failure30 and with naturally occurring chronic kidney disease 31. While not directly correlated with SP, 50% of the Greyhounds in this study had urinary albumin concentrations >1.0 mg/dL and 10% had concentrations >2.5 mg/dL, considered to be significant albuminuria.…”

Section: Discussionmentioning

confidence: 53%

Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non‐Greyhound Dogs

Martinez

Rogers

Kellogg

et al. 2016

Veterinary Internal Medicne

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BackgroundHypertension and albuminuria often coexist in Greyhounds, suggesting generalized vascular dysfunction that could contribute to the development of a variety of diseases in this breed. Eicosanoid metabolites of arachidonic acid (AA) mediate endothelial function, vascular reactivity, and proteinuria in humans and in rodent models.HypothesisThe eicosanoid profile of Greyhounds is shifted toward metabolites that promote vascular dysfunction, hypertension, and proteinuria.AnimalsHealthy Greyhounds (n = 20) and non‐Greyhound (n = 20) dogs that were consecutively enrolled in a blood donor program.MethodsProspective study. Plasma eicosanoid metabolites were assayed by liquid chromatography/electrospray ionization mass spectrometry (LC/ESI/MS) and compared to systolic blood pressure (SP) measurements and urine albumin concentration.ResultsIsomers of hydroxyeicosatetraenoic acid (HETE) were higher in Greyhounds than non‐Greyhounds (median, range in pmol/mL: 5(S)HETE 19.82, 8.55–32.95 versus 13.54, 4.33–26.27, P = .033; 8(S)HETE 9.39, 3.28–19.84 versus 5.80, 2.25–17.66, P = .002; 9(S)HETE 9.46, 2.43–13.79 versus 5.82, 1.50–17.16, P = .026; 12(S)HETE 10.17, 3.81–40.06 versus 7.24, 2.9–16.16, P = .022). Dihydroxyeicosatrienoic acid (DHET) isomers also were higher in Greyhounds compared to non‐Greyhounds (mean ± SD in pmol/mL: 8,9DHET 5.78 ± 2.13 versus 4.03 ± 1.36, P = .004; 11,12DHET 11.98 ± 2.86 versus 8.90 ± 3.48, P = .004; 14,15DHET 7.23 ± 2.19 versus 5.76 ± 1.87, P = .028). Albuminuria correlated with total DHET (rs = 0.46, P = .003). SP was positively correlated with 11,12EET (rs = 0.42, P = .006) and 20(S)HETE (rs = 0.38, P = .017). SP and 8,9EET were inversely correlated (rs = −0.49, P = .001).Conclusions and Clinical ImportancePlasma eicosanoid profile in Greyhounds was consistent with activation of metabolic pathways known to promote vascular dysfunction and might contribute to higher blood pressures and albuminuria. Inhibition of these eicosanoid pathways should be evaluated as therapeutic targets in Greyhounds.

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“…Hypertension could contribute to progression of renal damage, causing glomerulosclerosis as proteinuria and glomerular disease may occur in the majority of dogs with chronic kidney disease and systemic hypertension (Schellenberg et al 2008, Bacic et al 2010, Reusch et al 2010.…”

Section: Discussionmentioning

confidence: 99%

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

et al. 2017

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RESUMO.-[Avaliação da proteína urinária por eletroforese em cães com hiperadrenocorticismo hipófise dependente durante a terapia com trilostano.] Hiperadrenocorticismo (HAC) é uma das doenças endócrinas mais comuns em cães. A hipercortisolemia crônica pode causar danos glomerulares, pelo aumento da taxa de filtração glomerular, podendo levar ao desenvolvimento de doença renal crônica. Este estudo avaliou nove cães normotensos com hiperadrenocorticismo hipófise-dependente, antes e após a terapia com trilostano, durante o período de acompanhamento de seis meses, a fim de investigar o desenvolvimento de proteinúria patológica por métodos quantitativo (relação proteína e creatinina urinária) e qualitativos (eletroforese de proteínas urinárias) e também para monitorar a sua intensidade ao longo do curso da doença e terapia. A principal lesão renal detectada em cães com HAC foi no segmento tubular, evidenciada pela prevalência de bandas de proteínas urinárias de peso molecular mais baixo, indicando a falta de absorção destas proteínas no segmento proximal do néfron. A proteinúria de baixo peso molecular persistiu durante todo o acompanhamento. Em relação ao futuro da rotina clínica médica veterinária no tratamento de cães com hiperadrenocorticismo, as avaliações de proteinúria pela relação proteína e creatinina urinária e eletro- Hyperadrenocorticism is one of the most common endocrine disorders in dogs. Regarding to the kidneys, chronic hypercortisolemia can cause damage to the glomerulus, and evolve into chronic kidney disease. This study evaluated nine normotensive dogs with pituitary dependent hyperadrenocorticism, before and after therapy with trilostane, during the follow-up period of six months, in order to investigate the development of pathological proteinuria by quantitative (urinary protein-to-creatinine ratio) and qualitative (urinary protein electrophoresis) methods, and also to monitor its intensity over the course of the disease and therapy. The main renal lesion detected in dogs with hyperadrenocorticism was in the tubular segment, evidenced by the prevalence of urinary protein bands of lower molecular weight, indicating the lack absorption of these proteins in the proximal segment of the nephron. Low molecular weight proteins persisted throughout the follow-up. Regarding the future of routine veterinary medical clinic in the care of patients with hyperadrenocorticism, the assessments of proteinuria determinations by the urinary protein-to-creatinin ratio and urinary protein electrophoresis, according to the results obtained in this study, can add more information about the renal damage in these animals, and contribute to the prognosis. 735 Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane forese de proteínas urinárias, de acordo com os resultados obtidos neste estudo, podem adicionar mais informações sobre a lesão renal nestes animais e contribuir para o prognóstico.

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Evaluation of albuminuria and its relationship with blood pressure in dogs with chronic kidney disease

Cited by 40 publications

References 39 publications

Hypertension and its correlation with renal lesions in dogs with leishmaniosis

Hypertension and its correlation with renal lesions in dogs with leishmaniosis

Plasma Vasoprotective Eicosanoid Concentrations in Healthy Greyhounds and Non‐Greyhound Dogs

Urine protein electrophoresis study in dogs with pituitary dependent hyperadrenocorticism during therapy with trilostane

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