Evaluation of Alpha One Anti-Trypsin and Haptoglobin in Hypertensive Patients in Elele

In, Nnatuanya; Ei, Obeagu; Cic, Nnatuanya; Oa, Ogar; Ec, Stephen; A, Onah

doi:10.21767/2172-0479.100131

Cited by 1 publication

(1 citation statement)

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“…It is common but can be serious if not treated [1][2][3][4]. It is one of the most important risk factors for ischemic heart disease, stroke, other cardiovascular diseases, chronic kidney disease and dementia [5][6][7][8]. Estimates suggest that 31.1% of adults (1.39 billion) worldwide had hypertension in 2010.…”

Section: Introductionmentioning

confidence: 99%

Linking Malaria and Hypertension: Unveiling the Interconnected Pathophysiological Nexus

Ukibe,

Alex,

Osakue

et al. 2024

IDOSR-JSR

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Malaria, a devastating infectious disease caused by Plasmodium parasites, has long been recognized for its direct impact on global health. Recent studies have unveiled a potential connection between malaria infection and the development of hypertension, a prevalent cardiovascular disorder worldwide. Understanding the underlying pathophysiological mechanisms linking these seemingly disparate conditions is crucial for comprehensive disease management and prevention. The pathogenesis of malaria involves complex interactions between the parasite and the host immune system, resulting in systemic inflammation, endothelial dysfunction, and organ damage. Chronic exposure to Plasmodium infection induces alterations in vascular function, hemodynamics, and immune responses, potentially contributing to the development of hypertension. Several proposed mechanisms underscore the link between malaria and hypertension, including chronic inflammation, oxidative stress, endothelial dysfunction, and dysregulation of the renin-angiotensin-aldosterone system (RAAS). These mechanisms intertwine to disturb vascular homeostasis, leading to increased peripheral resistance and elevated blood pressure. Furthermore, the longterm consequences of repeated malaria episodes, especially in endemic regions, may potentiate vascular remodeling and contribute to the onset or exacerbation of hypertension in affected individuals. Genetic predispositions and environmental factors also play pivotal roles in modulating susceptibility to both malaria and hypertension. Recognition of this intricate association between malaria and hypertension prompts the necessity for integrated healthcare approaches encompassing effective malaria control strategies, early detection, and management of hypertension in endemic regions. Targeted interventions addressing common pathways, such as inflammation and endothelial dysfunction, may offer potential therapeutic avenues. Keywords: Malaria, Hypertension, Pathophysiology, Inflammation, Endothelial Dysfunction, Plasmodium Parasites, Cardiovascular Disorders, Immune Response, Vascular Remodeling, Global Health.

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