Evaluation of Amantodine Hydrochloride in the Treatment of A<sub>2</sub> influenzal Disease

Hornick, Richard B.; Togo, Yasushi; Mahler, Sara; Iezzoni, Domenic G.

doi:10.1111/j.1749-6632.1970.tb53386.x

Cited by 18 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Two other studies did not report differences in viral shedding patterns between patients treated with the M2 inhibitors and placebo. 23,28 Similarly, Togo et al 24 found no effect of amantadine treatment on the proportion of patients shedding virus over a 5-day period (Table 2A).…”

Section: Treatment Studiesmentioning

confidence: 91%

See 1 more Smart Citation

Influenza virus shedding—Excretion patterns and effects of antiviral treatment

Aoki¹,

Boivin²

2009

Journal of Clinical Virology

View full text Add to dashboard Cite

Section: Treatment Studiesmentioning

confidence: 91%

“…20 An assessment of studies with the M2 inhibitors shows that their effects on duration and magnitude of viral shedding are inconsistent compared with placebo or symptomatic therapy (Tables 1, 2A and 2B). [21][22][23][24][25][26][27] This section discusses the prophylactic and therapeutic effects of M2 inhibitors on viral shedding.…”

Section: M2 Inhibitorsmentioning

confidence: 99%

Influenza virus shedding—Excretion patterns and effects of antiviral treatment

Aoki¹,

Boivin²

2009

Journal of Clinical Virology

View full text Add to dashboard Cite

“…Amantadine hydrochloride (Symmetrel) has proved to be effective in the prophylaxis and treatment of influenza A2 (Togo et al, 1968;Galbraith et al, 1969;Hornick et al, 1969). It appears to act by preventing the virus from entering the cell (Davies et al, 1964) or by inhibiting an early stage of virus reproduction (Eggers, 1970), thereby enabling the natural defences of the body to overcome the infection.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Acute Herpes Zoster with Amantadine Hydrochloride (Symmetrel)

Galbraith¹

1973

BMJ

View full text Add to dashboard Cite

SummaryA double-blind, placebo-controlled trial of amantadine hydrochloride (Symmetrel) in acute herpes zoster (shingles) was carried out in 100 patients in general practice. The cases were serologically proved. There was no difference in duration of pain between the drug and placebo groups when pain disappeared during the 28 days' observation period. However, pain lasted more than 28 days in a significantly greater proportion of patients receiving placebo than of those on amantadine. Patients with pain after the 28-day observation period were significantly older than those whose pain disappeared during the study. The drug had no effect on rate of healing or appearance of new lesions.

show abstract