Evaluation of amygdalin-loaded alginate-chitosan nanoparticles as biocompatible drug delivery carriers for anticancerous efficacy

Sohail, Rabia; Abbas, Shah Rukh

doi:10.1016/j.ijbiomac.2020.02.191

Cited by 83 publications

(32 citation statements)

References 32 publications

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“…These are widely accepted due to their biodegradable and non-toxic nature. The different polymers are used for ocular polymeric nanoparticles, ie, tamarind kernel polysaccharide, 6 eudragit RS-100, 7 sodium alginate, 8 pectin, 9 chitosan, 10 and galactomannan. 11 Among these, chitosan (CH) is a well-known and most prominently used polymer in different ocular delivery systems.…”

Section: Introductionmentioning

confidence: 99%

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Bin-Jumah

Gilani

Jahangir³

et al. 2020

IJN

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The topically administered drugs through conventional delivery systems have low bioavailability. Henceforth, the present study was designed to prepare and optimize clarithromycin (CTM)-loaded chitosan nanoparticles (CHNPs) to demonstrate the efficacy against microorganisms. Methods: Clarithromycin-loaded chitosan nanoparticles (CTM-CHNPs) were prepared by ionotropic gelation method. The formulation was optimized by box-Behnken design using the formulation variables like CH (A), STPP concentration (B), and stirring speed (C). Their effects were evaluated on the independent variables like particle size (Y 1) and entrapment efficiency (Y 2). Further, CTM-CHNPs were evaluated for physicochemical parameters, invitro drug release, ex-vivo permeation, bioadhesive study, corneal hydration, histopathology, HET-CAM, and antibacterial study. Results: The optimized formulation (CTM-CHNPopt) showed the low particle size (152±5 nm), which is desirable for ocular delivery. It also showed high encapsulation (70.05%), zeta potential (+35.2 mV), and was found in a spherical shape. The drug release study revealed a sustained drug release profile (82.98±3.5% in 12 hours) with Korsmeyer peppas kinetic (R 2 =0.996) release model. It showed a 2.7-fold higher corneal permeation than CTMsolution. CHNPs did not exhibit any sign of damage to excised goat cornea, which is confirmed by hydration, histopathology, and HET-CAM test. It exhibited significant (P<0.05) higher antibacterial susceptibility than CTM-solution. Conclusion: The finding of the study concluded that CTM-CHNPs can be used for effective management of bacterial conjunctivitis by increasing the precorneal residence time.

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Section: Introductionmentioning

confidence: 99%

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Bin-Jumah

Gilani

Jahangir³

et al. 2020

IJN

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“…Alginate is a hydrophilic polymer with an anionic charge extracted from marine bacteria and brown seaweed. Due to its contrasting charge, alginate can easily form functional NPs with cationic polymers such as chitosan through polyelectrolyte complexation [79,86]. The formation of alginate-chitosan NPs via ionic interaction between carboxyl groups of alginate and amine groups of chitosan was reported by Sohail and Abbas [79].…”

Section: Types Of Polymers For Polymeric Nanoparticles Formation 231 Natural Polymersmentioning

confidence: 98%

“…Natural polymers are commonly used to prepare bioactive polymeric NPs. For example, hyaluronic acid, chitosan, alginate, and dextran have been used as biomaterials to construct NPs for cancer treatments [79,80]. Natural polymers exhibit biocompatible, biodegradable, non-cytotoxic, and non-immunogenic properties which are highly desirable in cancer therapy [81,82].…”

Section: Natural Polymersmentioning

confidence: 99%

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Neerooa

Ooi

Shameli

et al. 2021

Gels

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With cancer remaining as one of the main causes of deaths worldwide, many studies are undergoing the effort to look for a novel and potent anticancer drug. Nanoparticles (NPs) are one of the rising fields in research for anticancer drug development. One of the key advantages of using NPs for cancer therapy is its high flexibility for modification, hence additional properties can be added to the NPs in order to improve its anticancer action. Polymer has attracted considerable attention to be used as a material to enhance the bioactivity of the NPs. Nanogels, which are NPs cross-linked with hydrophilic polymer network have also exhibited benefits in anticancer application. The characteristics of these nanomaterials include non-toxic, environment-friendly, and variable physiochemical properties. Some other unique properties of polymers are also attributed by diverse methods of polymer synthesis. This then contributes to the unique properties of the nanodrugs. This review article provides an in-depth update on the development of polymer-assisted NPs and nanogels for cancer therapy. Topics such as the synthesis, usage, and properties of the nanomaterials are discussed along with their mechanisms and functions in anticancer application. The advantages and limitations are also discussed in this article.

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“…To cause an upsurge in the therapeutic activities and decrease the side-effects of amygdalin, the encapsulation of amygdalin is needed. Nanocarriers as smart drug delivery systems are being designed, developed, and investigated for many applications including therapeutics [38]. Nanoparticulate drug delivery has been exposed to vastly increaseitherapeutic activity duration, drug-stability, allowing the drug's parentior enteral administration, cumulativeiidrugipenetrability, thus minimizing oripreventing drug metabolism, cellulariiefflux, as wellias squalor [39].…”

Section: Microencapsulation and Bioavailabilitymentioning

confidence: 99%

“…ACNPs demonstrated better yet sustained anticancerous activity on H1299-cells in a dose-dependent manner than free-amygdalin, signifying better cellulariapproval of the previous. The authoridemonstrated that stableianioniciandicationic surface amygdalin-loaded ACNPs can beisynthesizedibyiionic gelation method with highicolloidal stability, as publicized by its zeta potential (−36 and + 32) having a size of ~119 nm and high drugiencapsulationiefficiency [38]. ACNPs presentediamplifiediswelling and sustained drug releaseishape with pH (3.1, 5.0, 7.4).…”

Section: Microencapsulation and Bioavailabilitymentioning

confidence: 99%

Amygdalin as a Plant-Based Bioactive Constituent: A Mini-Review on Intervention with Gut Microbiota, Anticancer Mechanisms, Bioavailability, and Microencapsulation

Barakat

2020

First International Electronic Conference on Nutrients, Microbiota and Chronic Disease

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Amygdalin—a plant-based bioactive constituent particularly abundant in bitter almond has been identified as featuring the cyanogenic glycoside chemical organic compound which was originally intended to be a medication for cancer treatment once hydrolyzed to hydrogen cyanide (HCN). Unfortunately, studies have revealed that HCN can similarly affect normal cells, rendering it harming the human body. Both in vivo and in vitro investigations are extremely controversial and make its use unsafe. An updated substantial review on the source, structure, intervention with gut microbiota, anticancer therapy, bioavailability, and microencapsulation of amygdalin was summarized. Amygdalin provided anti-tumor, anti-fibrotic, anti-atherosclerosis, anti-inflammatory, immunomodulatory, analgesic, ameliorating digestive and reproductive systems, and enhancing neurodegeneration as well as myocardial hypertrophy. Studies confirmed the toxicity of amygdalin produced by its HCN after oral ingestion. However, the intravenous route of administration was much less toxic than the oral route and can be avoided with an oral dosage ranging from 0.6 to 1 g daily. The diversity of gut consortium is a key factor in inducing toxicity by amygdalin. Indeed, there is no guaranteed way to point out the microbial consortium for each person and provide a safe oral dosage. Recently, the encapsulating of amygdalin using alginate–chitosaninanoparticles (ACNPs) as transporter was investigated. As an active drug delivery mechanism for regulated and constant release of amygdalin with its enhanced cytotoxic effect on cancerous cells, biocompatible and biodegradable ACNPs can be applied while protectinginormal cells and tissues. In conclusion, still unproven and conflicting facts give way to a broad avenue of researchifor a compound that could potentially be the next stage of cancer therapy.

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Evaluation of amygdalin-loaded alginate-chitosan nanoparticles as biocompatible drug delivery carriers for anticancerous efficacy

Cited by 83 publications

References 32 publications

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Development of Polymer-Assisted Nanoparticles and Nanogels for Cancer Therapy: An Update

Amygdalin as a Plant-Based Bioactive Constituent: A Mini-Review on Intervention with Gut Microbiota, Anticancer Mechanisms, Bioavailability, and Microencapsulation

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