Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats

Kim, Charles Y.; Kumar, Ashok; Sampath, Lester; Sokol, Karen; Modak, Shanta

doi:10.1053/ajkd.2002.29911

Cited by 27 publications

(20 citation statements)

References 39 publications

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“…Recently, implantable infusion pumps have been developed for the treatment of several diseases, 26) and endoscopic and laparoscopic surgical techniques have made remarkable progress. 27) Furthermore, continuous ambulatory peritoneal dialysis is an extremely common treatment modality for end-stage renal failure, 28) indicating that techniques for inserting catheters in intraperitoneal cavity will advance in the future. Taking these into consideration, the clinical application of pDNA to the liver surface should become possible.…”

Section: Resultsmentioning

confidence: 99%

Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice

Hirayama

Nishida

Fumoto

et al. 2004

Biological & Pharmaceutical Bulletin

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Section: Resultsmentioning

confidence: 99%

Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice

Hirayama

Nishida

Fumoto

et al. 2004

Biological & Pharmaceutical Bulletin

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“…7) Recently, implantable infusion pumps have been developed for the treatment of several diseases, 8) and remarkable progress has been made in endoscopic and laparoscopic operation techniques. 9,10) Furthermore, continuous ambulatory peritoneal dialysis is an extremely common treatment modality for end stage renal failure 11) ; consequently, the skill needed for inserting the catheter on the intraperitoneal organs should be improved in the future. Scheyer and Zimmermann 10) reported that a collagen fleece coated with fibrin glue could be inserted on liver and stomach by endoscopic surgery, suggesting that a dosage form, which could achieve the controlled drug release, could be applied to the kidney surface by endoscopic surgery.…”

Section: Resultsmentioning

confidence: 99%

Effect of the Absorption Enhancer Saponin on the Intrarenal Distribution of 5-Fluorouracil Following Its Kidney Surface Application in Rats

Nakamura

Horimoto

Hirayama

et al. 2003

Biological & Pharmaceutical Bulletin

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The response rate to chemotherapy for treating renal cell carcinoma is less than 20%.1) Renal cell carcinomas are normally located unilaterally in the kidneys, and accordingly renal arterial administration has been studied to deliver anticancer drugs to the unilateral kidney.2) When a drug is administered systemically, however, it is distributed throughout the whole body via the blood stream, leading to inadequate drug delivery to the target organ. We have described the kidney-and site-selective delivery of 5-fluorouracil (5-FU) by the application of 5-FU to the kidney surface in rats.

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“…16) Recently, implantable infusion pumps have been developed for the treatment of several diseases, 17) and endoscopic and laparoscopic operation techniques have made marked progress. 18,19) Furthermore, continuous ambulatory peritoneal dialysis is an extremely popular treatment modality for end stage renal failure; 20) consequently, the skilled catheter insertion into the intraperitoneal organs should be advanced in the future. It was reported that a collagen fleece coated with fibrin glue could be inserted on the liver and stomach by endoscopic surgery, 19) suggesting that proper pharmaceutics with drugs, which could achieve controlled drug release, could be applied to the gastric serosal surface by endoscopic surgery.…”

Section: Discussionmentioning

confidence: 99%

Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats

Nakamura

Kobayashi

Fumoto

et al. 2005

Biological & Pharmaceutical Bulletin

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Advanced gastric cancer with serosal invasion is usually unresectable, so anticancer drugs are infused intravenously as a palliative treatment; however, patients with unresectable gastric cancer die within a few months after exploration, with or without palliative surgery. 5-Fluorouracil (5-FU) is the cornerstone chemotherapy regimen for gastric cancer, having mild to moderate toxicity and response rate.1) However, the activity of single agents, including 5-FU, against gastric cancer is approximately 20% or less.2) To improve the therapeutic effect of anticancer drugs on gastric cancer, intraarterial administration has been studied. 3,4) When the anticancer drugs are administered via the vasculature route, however, they are distributed through the whole body via the blood stream, leading to inadequate delivery to target sites in the stomach, as well as potential toxicity in other organs. These circumstances underscore the need for novel and more effective strategies for the treatment of gastric cancer.Thus, stomach-and site-selective drug delivery is a very important strategy for the optimization of chemotherapy in terms of efficacy and safety. We originally elucidated that phenol red, bromphenol blue, and bromosulphonphthalein as model drugs are adequately absorbed from the gastric serosal surface and accumulate site-selectively in the stomach in rats. 5,6) Although the gastric serosal surface application of anticancer drugs holds promise for site-selective delivery in the stomach, little is known about the gastric and systemic distribution characteristics of anticancer drugs following application on the gastric serosal surface. In the present study, we examined the detailed absorption and distribution characteristics of 5-FU following application on the gastric serosal surface for the site-selective delivery of 5-FU in the stomach in rats. MATERIALS AND METHODSChemicals 5-FU was purchased from Nacalai Tesque, Inc. (Kyoto, Japan). All other chemicals were of reagent grade.Absorption and Distribution Experiments All experiments in the present study were carried out in accordance with the Guidelines for Animal Experimentation of Nagasaki University. Male Wistar rats (250-270 g) were anesthetized with sodium pentobarbital (50 mg/kg i.p.). After the peritoneum was dissected about 5 cm, a cylindrical diffusion cell (i.d. 9 mm, effective area 0.64 cm 2 ) was attached to the gastric serosal surface with surgical adhesive (Aron Alpha A, Sankyo Co. Ltd., Tokyo, Japan), and 5-FU (0.2, 2, and 10 mg/mlϫ0.5 ml, isotonic phosphate-buffered saline, pH 7.4) was added directly to the cylindrical diffusion cell (Chart 1). The body temperature of the rats was maintained at 37°C with a heat lamp during the experiment. As a control experiment, 5-FU (10 mg/mlϫ0.5 ml, isotonic phosphatebuffered saline, pH 7.4) was administered intravenously using a syringe with a needle (26Gϫ1/2Љ) and orally by gastric intubation. After application on the gastric serosal surface, the solution in the diffusion cell and the blood was sampled at appropr...

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Evaluation of an antimicrobial-impregnated continuous ambulatory peritoneal dialysis catheter for infection control in rats

Cited by 27 publications

References 39 publications

Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice

Liver Site-Specific Gene Transfer Following the Administration of Naked Plasmid DNA to the Liver Surface in Mice

Effect of the Absorption Enhancer Saponin on the Intrarenal Distribution of 5-Fluorouracil Following Its Kidney Surface Application in Rats

Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats

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