Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones

Biruss, Babette; Kählig, Hanspeter; Valenta, Claudia

doi:10.1016/j.ijpharm.2006.08.003

Cited by 64 publications

(27 citation statements)

References 35 publications

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“…27,28) eucalyptus oil/ cineole has been shown to enhance the skin penetration of many drugs under in vitro conditions. [29][30][31][32] To our knowledge, this is the first time eucalyptus oil/cineole has been used in a human clinical trial. During our pharmacokinetic studies, no adverse events were reported and no signs of skin irritation/ sensitization were observed.…”

Section: Discussionmentioning

confidence: 90%

Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and in Vitro/in Vivo Correlation

Shen

Weng

et al. 2013

Biological & Pharmaceutical Bulletin

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Section: Discussionmentioning

confidence: 90%

Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch versus Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and in Vitro/in Vivo Correlation

Shen

Weng

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Polydispersity index (PDI) is an important parameter in the characterization of colloidal drug carriers since it reflects the physical stability of the system and provides information about homogeneity of the samples 29,30 . The PDI values lower than 0.4 indicated homogenous microemulsion systems with narrow size distribution in our study.…”

Section: Droplet Size Measurementsmentioning

confidence: 99%

Development and in vitro characterization of microemulsions of isotretinoin

Gürbüz¹,

Güngör²,

Erdal³

2017

actapharm

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“…Several hypotheses have been put forward for the mechanism of drug permeation enhancement. These include increased drug solubility, which fosters a high concentration gradient towards skin, small droplet size and low viscosity which facilitates permeation, increased drug thermodynamic activity in the microemulsion vehicle, and the disruption of the stratum corneum lipid order by microemulsion components (Kreilgaard, 2002;Zhao et al, 2006;Biruss, Kählig, Valenta, 2007;Gupta, Moulik, 2008;Vicentini et al, 2008;Moniruzzaman, Kamiya, Goto, 2010;Shakeel, Ramadan, 2010).…”

Section: Introductionmentioning

confidence: 99%

Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

Pascoa

Diniz

Florentino

et al. 2015

Braz. J. Pharm. Sci.

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This article reports the development of a pharmaceutical product containing vegetable actives from a Brazilian medicinal plant. The possibility of forming a microemulsion using Pterodon emarginatus ("sucupira") oil was evaluated and the anti-inflammatory potential of this microemulsion was also examined. A formulation was developed using P. emarginatus oil, a mixture of ethoxylated Castor Oil (Ultramone ® R-540/propylene glycol 2:1) (surfactant/cosurfactant) and distilled water at a ratio of 10:15:75, respectively. The microemulsion which was selected was then subjected to the preliminary stability test and analyzed in terms of average diameter of droplets, pH, zeta potential, and polydispersity index, on the 1 st , 7 th , 15 th , and 30 th days after preparation and stored at different temperatures (5 ± 2 °C, 25 ± 2 °C, and 40 ± 2 °C). The anti-inflammatory in vivo activity of both oil and formulation were evaluated, using the experimental model of croton oil-induced ear edema. The preliminary stability test showed that the microemulsion stored at 5 and 25 °C retained its original features throughout the 30-day period. The anti-inflammatory potential of both oil and formulation was shown to be statistically significant (p < 0.001), when compared to the control group, however, the microemulsion proved to be more effective (p < 0.05) than the oil when applied directly to the ear. Descrevemos o desenvolvimento de um produto farmacêutico contendo ativo vegetal baseado em uma planta medicinal brasileira. Foi avaliada a habilidade de formação de uma microemulsão à base do óleo de Pterodon emarginatus (sucupira) e seu potential anti-inflamatório. Uma formulação foi desenvolvida utilizando o óleo de P. emarginatus, mistura de óleo de mamona etoxilado (Ultramona ® R-540)/propilenoglicol (2:1) (tensoativo/cotensoativo) e água destilada, na proporção de 10:15:75, respectivamente. A microemulsão selecionada foi submetida ao teste preliminar de estabilidade e foi analisada quanto ao diâmetro médio das gotículas, pH, potential zeta e índice de polidispersão, no 1º, 7º, 15º e 30º dias após o preparo e foram estocadas em diferentes temperaturas (5±2 °C, 25±2 °C e 40±2 °C). Avaliaram-se a atividade anti-inflamatória in vivo do óleo de sucupira e da formulação, usando o modelo experimental do edema de orelha induzido pelo óleo de cróton. No teste preliminar de estabilidade observou-se que a formulação estocada a 5 °C e a 25 °C mantiveram suas características originais durante 30 dias. O potencial anti-inflamatório de ambos, óleo de sucupira e formulação foi estatisticamente significativo (p <0.001), quando comparado ao controle, porém a microemulsão foi mais eficiente (p <0.05) que o óleo aplicado diretamente nas orelhas dos animais. Unitermos:Pterodon emarginatus/pharmacognosy. Pterodon emarginatus/óleo/atividade antiinflamatória. Plantas medicinais. Microemulsão. Fitoterápico. Tecnologia farmacêutica.

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Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones

Cited by 64 publications

References 35 publications

Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch <i>versus</i> Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and <i>in Vitro</i>/<i>in Vivo</i> Correlation

Single- and Multiple-Dose Pharmacokinetics of a Novel Tetramethylpyrazine Reservoir-Type Transdermal Patch <i>versus</i> Tetramethylpyrazine Phosphate Oral Tablets in Healthy Normal Volunteers, and <i>in Vitro</i>/<i>in Vivo</i> Correlation

Development and in vitro characterization of microemulsions of isotretinoin

Microemulsion based on Pterodon emarginatus oil and its anti-inflammatory potential

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