The explosion in neuroscientific knowledge has profound implications for education, and we advocate the establishment of the new discipline of 'pedagogical neuroscience' designed to combine psychological, medical, and educational perspectives. We propose that specific learning disabilities provide the crucible in which the discipline may be forged, illustrating the scope by consideration of developmental dyslexia. Current approaches have failed to establish consensus on fundamental issues such as theoretical causes, diagnostic methods, and treatment strategies. We argue that these difficulties arise from diagnosis via behavioural or cognitive symptoms, even though they may arise from diverse causes. Rather than an inconvenience, variability of secondary symptoms within and across learning disabilities can inform both diagnosis and treatment. We illustrate how brain-based theories lead to radical restructuring of diagnostic methods and propose that there is an urgent need to develop genetic and brain-based diagnostic methods designed to lead to individuallyappropriate remediation and treatment methods.Pedagogy is the art and science of teaching and learning. The principles of behavioural learning theory (including study of reinforcement, habit, massed and distributed practice, rote learning, memory, and motivation) underpinned the pedagogy of the mid-20th century, but subsequently, a more eclectic, explicitly applied approach has evolved to the extent that practitioners have bemoaned the disappearance of pedagogy from education in the UK. 1 We argue that the extraordinary recent progress of research into cognitive neuroscience and genetics has provided new theoretical ideas to reunite the theoretical and applied perspectives, thereby transforming the processes of education. Craik 2 argued that 'in any well-made machine one is ignorant of the working of most of the partsthe better they work the less we are conscious of them… it is only a fault which draws our attention to the existence of the mechanism at all'. In the mid-1980s the cognitive neuropsychology approach applied these principles to patients with brain damage, arguing that their study could fractionate the workings of the mind in ways not possible in brains that function normally. In this article we propose that the study of the specific learning disabilities* (alternatively known as developmental disorders) may provide the same function for the development of pedagogical neuroscience. We illustrate the potential by discussion of developmental dyslexia.The earliest research in dyslexia adopted a medical perspective, 3,4 but more recently the educational perspective has taken precedence, largely because the manifestations of dyslexia are mainly in literacy and the impact is greatest for children in school. The prevalence of dyslexia in developed countries' school populations is around 5% 5,6 impacting not only on the development of literacy skills, but also throughout life. In a recent review of more than 1500 references on dyslexia, Demonet et al. 7 hig...