Evaluation of an Iodonium Compound as an Antiseptic Agent

Engelhard, Warren E.; Worton, Albert G.

doi:10.1002/jps.3030450616

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…5 ). First, the hydrolysis of ester 11 afforded an acid ( 12 ). This compound was reacted with propargyl amine to produce the iodoaryl compound 4.…”

Section: Resultsmentioning

confidence: 99%

“…The efficacy of dpI and derivatives has been previously demonstrated in Gram-positive bacteria Staphylococcus aureus and Streptococcus pyogenes , Gram-negative pathogen Helicobacter pylori , as well as Mycobacterium tuberculosis , including MDR strains of these bacteria ( 11 – 14 ). Most derivatives were found to have moderate inhibitory potency against E. coli .…”

Section: Discussionmentioning

confidence: 99%

“…Iodonium salts such as diphenyleneiodonium (dpI) ( Fig. 1 ) chloride are antiseptics against Gram-positive bacteria with moderate inhibitory activity against Gram-negative bacteria (GNB) such as A. baumannii ( 11 – 15 ). To the best of our knowledge, the biological targets and mechanisms of action of iodonium compounds in bacteria are not well characterized in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii

et al. 2023

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Discovery of novel antibiotics targeting multidrug-resistant (MDR) pathogens such as A. baumannii is an urgent, unmet medical need. Our work has highlighted the potential of this unique scaffold to annihilate MDR A. baumannii alone and in combination with amikacin both in vitro and in animals, that too without inducing resistance. Further in depth analysis identified central metabolism to be a putative target. Taken together, these experiments lay down the foundation for effective management of infections caused due to highly MDR pathogens.

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“…5 ). First, the hydrolysis of ester 11 afforded an acid ( 12 ). This compound was reacted with propargyl amine to produce the iodoaryl compound 4.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii

et al. 2023

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“…More specifically, some iodoniuin compounds, which are members of a group of compounds in which iodine is an integral part of the structure and is the positive ion, have exhibited inhibitory ability against various lnicroorganisms (Engelhard and Worton 1956;Freedlander and French 1946). A compound has been synthesized in which iodine is incorporated in a heterocyclic structure as a phenoxiodininium.…”

Section: Introductionmentioning

confidence: 99%

The antibacterial action of phenoxiodinin-5-ium chloride

Inniss¹

1968

Can. J. Microbiol.

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Phenoxiodinin-5-ium chloride (PC) is a synthetic organic compound possessing a little known type of iodine-containing structure and has been found to possess antibacterial activity. A study was conducted to gain some insight into the mechanism by which it exerted its effect on bacteria. The compound inhibited oxygen uptake and 14CO2 evolution from uniformly labelled glucose-14C by Staphylococcus aureus, under both resting and growing cell conditions. The assimilation of glucose-14C and L-methionine-methyl-14C into cellular material was also affected. A release of 14C-labelled cellular material from whole cells and from spheroplasts stabilized in 0.5 M sucrose occurred in the presence of PC. PC also inhibited succinate and lactate dehydrogenase systems in whole cells and cell membranes of Bacillus megaterium. When sodium malonate, a highly specific inhibitor of succinate dehydrogenase, was substituted for PC, an increased release of 14C-intra-cellular material also occurred. PC possesses the ability to inhibit enzymes located on the cell membrane of S. aureus and B. megaterium.

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Studies on the analytical chemistry of iodonium compounds. Part VIII

Bowd

Burns

1972

Microchim Acta

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Evaluation of an Iodonium Compound as an Antiseptic Agent

Cited by 5 publications

References 5 publications

Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii

Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii

The antibacterial action of phenoxiodinin-5-ium chloride

Studies on the analytical chemistry of iodonium compounds. Part VIII

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