Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients

Cheng, Karis Kin Fong; Molassiotis, Alex; Chang, Allan; Wai, Wint; Cheung, Slc

doi:10.1016/s0959-8049(01)00098-3

Cited by 160 publications

(132 citation statements)

References 20 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…Several studies observed a significant reduction in the duration and severity of oral mucositis. 21,23 Other trials did not see an effect superior to a mouth rinse with water. 19,24,27 For the effect on the oral microflora, results are as heterogenous.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, many prophylactic regimens aimed at the prevention of oral infection by using different anti-infective mouth rinses. [19][20][21][22][23][24][25] The anti-infectives used in our study, that is, PVP, chlorhexidine, polyenes, and sage tea, have been examined in previous clinical trials. Some of these trials examined their effectiveness in preventing or alleviating mucositis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Lövenich¹,

Schütt-Gerowitt²,

Keulertz³

et al. 2005

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Autologous stem cell transplantation has augmented treatment successes. However, high-dose chemotherapy is still accompanied by dose-limiting toxicities, for example, severe mucositis. Mucosal lesions serve as portals of entry for infections. In order to reduce the oral microbial burden, we prospectively evaluated the microbiological impact of a complex regimen of mouth rinses consisting of concomitantly applied polyene antifungals, povidone-iodine, chlorhexidine, sage tea, and prophylactic ciprofloxacin and fluconazole. A total of 15 patients were enrolled into this longitudinal evaluation. Colony-forming units (CFU) were quantitated from saliva, buccal and palatinal swabs during high-dose chemotherapy and autologous stem cell transplantation. The number of CFU did not show any significant changes after initiation of the mouth rinses and the prophylactic antibiotics. The median CFU count was 268 Â 10 6 /ml saliva before chemotherapy and decreased after initiation of intravenous antibiotics only. Neither prophylactic nor therapeutic antifungals significantly reduced the number of cultures positive for yeasts. Since 90% of our patients had febrile neutropenia at some time point during the observation period, the approach evaluated cannot be recommended as prophylaxis of febrile neutropenia as such.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Lövenich¹,

Schütt-Gerowitt²,

Keulertz³

et al. 2005

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…In the theme review regarding the importance of a thorough assessment of the mouth as an essential tool to identify early alterations to the mucosa integrity, the most mentioned outcomes were the assessment of oral hygiene activities, nutrition, and oral self-care (29)(30)(31) . The need for assessments and control of the pain presented by serious mucositis patients was also mentioned, mainly considering patients' quality of life (30) .…”

Section: Discussionmentioning

confidence: 99%

Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática

Ferreira¹,

Gamba

Saconato

et al. 2011

Acta paul. enferm.

View full text Add to dashboard Cite

Objective: To identify therapeutic measures to reduce the severity of oral mucositis in adult patients undergoing bone marrow transplantation (BMT). Methods: A systematic review using the following databases: LILACS, MEDLINE, CINAHL, EMBASE, CENTRAL (Cochrane Central) and DARE (Database of abstracts of reviews of effects), for the period between 1972 to July 2010, using the key words mucositis, stomatitis and bone marrow transplantation. Results: We identified 3,839 abstracts, 22 of which were included in the systematic review; these articles identified 14 topical and systemic interventions, among which eight showed statistical significance for the reduction of this complication. The topical therapies were: cryotherapy, chlorhexidine, glutamine, laser and Traumeel ®. The systemic therapies were: amifostine, Granulokine ®, and palifermin. Conclusion: The heterogeneity of the results of these interventions and the lack of better elucidation for healthcare practice indicate the need for more accurate research to identify the effectiveness of topical therapies for repair of mucosal cells.

show abstract

“…A mucosite oral ocorre de 3 a 5 dias após quimioterapia com evolução de 2 a 3 semanas (CHENG et al, 2001). Manifesta-se clinicamente por eritema, ulcerações, edema e sangramento (COWEN et al, 1997).…”

Section: Lista De Tabelasunclassified

“…A freqüência de ocorrência da mucosite oral é em média 40% sendo a incidência variável de acordo com a dose e tipo de quimioterápico usado (FOCAZIO, 1997;LOWE, 1986;SCULLY;SONIS;DIZ, 2006 (CHENG et al, 2001;CHIAPELLI, 2005;LALLA;PETERSON, 2005;MIGLIORATI et al, 2001). Edema, hemorragia são também citados (COWEN et al, 1997;LOWE, 1986;SAADEH, 2005).…”

Section: Lista De Tabelasunclassified

Utilização de laser de baixa intensidade, infravermelho, na prevenção e tratamento da mucosite oral em pacientes pediátricos com leucemia linfoblástica aguda

Mauricio¹

View full text Add to dashboard Cite

Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients

Cited by 160 publications

References 20 publications

Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation

Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática

Utilização de laser de baixa intensidade, infravermelho, na prevenção e tratamento da mucosite oral em pacientes pediátricos com leucemia linfoblástica aguda

Contact Info

Product

Resources

About