Evaluation of anal sphincter resistance and distensibility in healthy controls using EndoFLIP ©

Alqudah, Maha; Gregersen, Hans; Drewes, Asbjørn Mohr; McMahon, Barry P.

doi:10.1111/nmo.12028

Cited by 36 publications

(47 citation statements)

References 23 publications

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“…14 Similar results were reported by Alqudah et al 37 In a study by Gourcerol et al 38 comparing the use of EndoFLIP and 3-dimensional high-resolution manometry, it was found that anal distensibility index was higher at rest and during voluntary contraction in fecal incontinence than in healthy subjects, and that the discrimination was better using the distensibility index as compared with the anal pressure. EndoFLIP may be used intra-operatively to assess the anal sphincter geometry and tightness during repair or augmentation.…”

Section: Anal Sphincter Evaluation and Fecal Incontinencesupporting

confidence: 76%

Emerging Roles of the Endolumenal Functional Lumen Imaging Probe in Gastrointestinal Motility Disorders

Ata-Lawenko

Lee

2017

J Neurogastroenterol Motil

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Gastrointestinal sphincters play a vital role in gut function and motility by separating the gut into functional segments. Traditionally, function of sphincters including the esophagogastric junction is studied using endoscopy and manometry. However, due to its dynamic biomechanical properties, data on distensibility and compliance may provide a more accurate representation of the sphincter function. The endolumenal functional lumen imaging probe (EndoFLIP) system uses a multi-detector impedance planimetry system to provide data on tissue distensibility and geometric changes in the sphincter as measured through resistance to volumetric distention with real-time images. With the advent of EndoFLIP studies, esophagogastric junction dysfunction and other disorders of the stomach and bowels may be better evaluated. It may be utilized as a tool in predicting effectiveness of endoscopic and surgical treatments as well as patient outcomes.

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Section: Anal Sphincter Evaluation and Fecal Incontinencesupporting

confidence: 76%

Emerging Roles of the Endolumenal Functional Lumen Imaging Probe in Gastrointestinal Motility Disorders

Ata-Lawenko

Lee

2017

J Neurogastroenterol Motil

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“…An additional study on volunteers showed a higher opening pressure for women than for men [55]. This suggests a different distensibility in men and women, but the findings were not consistent with earlier manometric findings.…”

Section: Anal Sphincterscontrasting

confidence: 51%

“…So far, only four studies have been published [54][55][56][57]. In vitro tests have shown FLIP distensibility measurements to have great validity and reproducibility [54].…”

Section: Anal Sphinctersmentioning

confidence: 99%

Functional lumen imaging of the gastrointestinal tract

et al. 2015

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This nonsystematic review aims to describe recent developments in the use of functional lumen imaging in the gastrointestinal tract stimulated by the introduction of the functional lumen imaging probe. When ingested food in liquid and solid form is transported along the gastrointestinal tract, sphincters provide an important role in the flow and control of these contents. Inadequate function of sphincters is the basis of many gastrointestinal diseases. Despite this, traditional methods of sphincter diagnosis and measurement such as fluoroscopy, manometry, and the barostat are limited in what they can tell us. It has long been thought that measurement of sphincter function through resistance to distension is a better approach, now more commonly known as distensibility testing. The functional lumen imaging probe is the first medical measurement device that purports in a practical way to provide geometric profiling and measurement of distensibility in sphincters. With use of impedance planimetry, an axial series of cross-sectional areas and pressure in a cathetermounted allantoid bag are used for the calculation of distensibility parameters. The technique has been trialed in many valvular areas of the gastrointestinal tract, including the upper esophageal sphincter, the esophagogastric junction, and the anorectal region. It has shown potential in the biomechanical assessment of sphincter function and characterization of swallowing disorders, gastroesophageal reflux disease, eosinophilic esophagitis, achalasia, and fecal incontinence. From this early work, the functional lumen imaging technique has the potential to contribute to a better and more physiological understanding of narrowing regions in the gastrointestinal tract in general and sphincters in particular.

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“…The measurement of the corresponding intra‐bag pressure makes it possible to assess the CSA pressure response (distensibility) of the organ . The EndoFLIP ® was originally designed to study dynamic wall properties at the gastro‐esophageal junction and has also been used to assess the distensibility of the anal canal in healthy volunteers . Two preliminary studies using the EndoFLIP ® have reported increased anal distensibility in small populations of FI patients .…”

Section: Introductionmentioning

confidence: 99%

Do endoflip assessments of anal sphincter distensibility provide more information on patients with fecal incontinence than high‐resolution anal manometry?

Gourcerol

Granier

Bridoux

et al. 2015

Neurogastroenterology Motil

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Evaluation of anal sphincter resistance and distensibility in healthy controls using EndoFLIP ©

Abstract: This distensibility technique provides an important new way of studying the anal canal and hence may have a role in testing sphincter competence in patients with disorders.

Cited by 36 publications

References 23 publications

Emerging Roles of the Endolumenal Functional Lumen Imaging Probe in Gastrointestinal Motility Disorders

Emerging Roles of the Endolumenal Functional Lumen Imaging Probe in Gastrointestinal Motility Disorders

Functional lumen imaging of the gastrointestinal tract

Do endoflip assessments of anal sphincter distensibility provide more information on patients with fecal incontinence than high‐resolution anal manometry?

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