Evaluation of analgesia by epidural magnesium sulphate versus fentanyl as adjuvant to levobupivacaine in geriatric spine surgeries. Randomized controlled study

Abstract

(2017) Evaluation of analgesia by epidural magnesium sulphate versus fentanyl as adjuvant to levobupivacaine in geriatric spine surgeries. Randomized controlled study, Egyptian

Comparative evaluation of epidural bupivacaine alone and bupivacaine combined with magnesium sulfate in providing postoperative analgesia: a meta-analysis of randomized controlled trials

“…We found that many studies did not adequately report randomization methods. Five studies did not describe the generation of random sequences in detail [12,14,15,19,22], two studies did not describe the methods of allocation concealment [17,18], three studies did not describe whether the anaesthetists were blind for this study design [14,15,20] and four studies did not report in detail their blind assessment of the outcomes [14,15,20,21]. Only one studies reported clinical trials registration [12] and we were not clear about the risk of selective outcome reporting bias.…”

“…The literature search identified 4392 studies totally and 112 references from CENTRAL, 2481 references from MEDLINE (OvidSP), and 1799 studies from Embase (Ovidsp). Eleven studies fulfilled our inclusion criteria after screening [12][13][14][15][16][17][18][19][20][21][22]. The details of retrieval was shown in Fig.…”

“…The various characteristics of the included studies were shown in Table 1. Seven trials applied magnesium sulfate as a bolus followed by a continuous infusion [12][13][14][15][16][17][18], while the remaining four trials applied a bolus injection [19][20][21][22]. In eight studies enrolled participants undergoing Lower abdominal or lower limb surgeries [12,13,15,[17][18][19][20]22], with participants administered epidural anesthesia.…”

“…3 presents the risk of bias of the included studies. We assessed 3 of these trials as low risk of bias [12,13,16], while the remaining 8 trials as high risk of bias according to our pre-specified criteria [14,15,[17][18][19][20][21][22].…”

“…Five studies including 304 patients reported the number of patients required rescue analgesics [12,16,18,19,21]. The merged effect analysis showed that it was significantly less in magnesium group compared with control group (RR 0.38; 95% CI [0.20, 0.74], P = 0.004, I 2 = 75%, Fig.…”